ChemicalBook > CAS DataBase List > 3-Chloro-4-hydroxyphenylboronic acid

3-Chloro-4-hydroxyphenylboronic acid

Product Name: 3-Chloro-4-hydroxyphenylboronic acid
CAS No.: 182344-13-4
Chemical Name: 3-Chloro-4-hydroxyphenylboronic acid
Synonyms: 4-Borono-2-chlorophenol;(3-Chloro-4-hydroxyphenyl);3-Chloro-4-hydroxyphenylboronic acid;(3-chloro-4-hydroxyphenyl)boronicaci;3-Chloro-4-hydroxybenzeneboronic acid;3-Chloro-4-hydroxybenzeneboronicacid96%;B-(3-chloro-4-hydroxy-phenyl)boronic acid;Boronic acid, B-(3-chloro-4-hydroxyphenyl)-;3-Chloro-4-hydroxyphenylboronic Acid (contains varying amounts of Anhydride)
CBNumber: CB01457368
Molecular Formula: C6H6BClO3
Formula Weight: 172.37
MOL File: 182344-13-4.mol

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3-Chloro-4-hydroxyphenylboronic acid Property

Melting point:: 223-228°C
Boiling point:: 360-361°
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: powder to crystal
color: White to Light yellow to Light red
CAS DataBase Reference: 182344-13-4

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Safety

Hazard Codes: Xi
HazardClass: IRRITANT, KEEP COLD
HS Code: 2931900090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical

Product number: C2969
Product name: 3-Chloro-4-hydroxyphenylboronic Acid (contains varying amounts of Anhydride)
Packaging: 1g
Price: $52
Updated: 2024/03/01

TCI Chemical

Product number: C2969
Product name: 3-Chloro-4-hydroxyphenylboronic Acid (contains varying amounts of Anhydride)
Packaging: 5g
Price: $193
Updated: 2023/06/20

TRC

Product number: C421963
Product name: 3-Chloro-4-hydroxyphenylboronicacid
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: C421963
Product name: 3-Chloro-4-hydroxyphenylboronicacid
Packaging: 1g
Price: $75
Updated: 2021/12/16

Chem-Impex

Product number: 40304
Product name: 3-Chloro-4-hydroxyphenylboronicacid,97-105%(Assaybytitration)
Purity: 97-105%(Assaybytitration)
Packaging: 1G
Price: $50.4
Updated: 2021/12/16

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3-Chloro-4-hydroxyphenylboronic acid Chemical Properties,Usage,Production

Uses

suzuki reaction

Synthesis

3964-56-5

182344-13-4

General procedure for the synthesis of 3-chloro-4-hydroxyphenylboronic acid from 4-bromo-2-chlorophenol: 1. n-BuLi (12 mL of 2.44 M solution, 29 mmol) was added slowly and dropwise to a stirring solution of 4-bromo-2-chlorophenol (5 g, 24 mmol) in anhydrous THF (75 mL) at -78°C and stirring was continued for 2 hours at -78°C. 2. trimethyl borate (3.3 mL, 29 mmol) was added to the reaction mixture, followed by allowing the reaction mixture to slowly warm to room temperature and stirring for 19 hours. 3. The reaction was quenched using 2M HCl aqueous solution followed by organic phase extraction with EtOAc (2 x 60mL). 4. The organic extracts were combined and concentrated under reduced pressure to give an oily substance containing a white precipitate. 5. Hexane was added to the oily substance, and the white powder was collected by filtration and washed with hexane. Yield: 15%. 1H NMR (270 MHz, DMSO-d6) δ: 6.49 (bs), 6.91 (1H, d, J = 7.9 Hz), 7.54 (1H, dd, J = 8.2, 1.5 Hz), 7.72 (1H, d, J = 1.5 Hz), 8.02 (bs), 10.32 (1H, s). HPLC retention time: 3.36 min (>91% purity, aqueous solution of 90% MeCN). LC/MS (APCI) m/z: 171.16 (M-H)-.

References

[1] Patent: WO2007/96647, 2007, A2. Location in patent: Page/Page column 125-126
[2] Patent: WO2007/68905, 2007, A1. Location in patent: Page/Page column 120-121; 148-149; 152-153; 154-155
[3] Journal of the American Chemical Society, 2007, vol. 129, # 7, p. 1894 - 1895

3-Chloro-4-hydroxyphenylboronic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-Chloro-4-hydroxyphenylboronic acid manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3-Chloro-4-hydroxyphenylboronic acid 182344-13-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3-Chloro-4-hydroxyphenylboronic acid 182344-13-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

Career Henan Chemical Co

Product: 3-Chloro-4-hydroxyphenylboronic acid 182344-13-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg; 5kg; 100kg
Release date: 2019-07-03

182344-13-4, 3-Chloro-4-hydroxyphenylboronic acidRelated Search:

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3-Chloro-4-hydroxyphenylboronic Acid (contains varying amounts of Anhydride)

(3-Chloro-4-hydroxyphenyl)

B-(3-chloro-4-hydroxy-phenyl)boronic acid

3-Chloro-4-hydroxyphenylboronic acid

3-Chloro-4-hydroxybenzeneboronic acid

4-Borono-2-chlorophenol

Boronic acid, B-(3-chloro-4-hydroxyphenyl)-

(3-chloro-4-hydroxyphenyl)boronicaci

182344-13-4

Boronate Ester

Boronic Acid

Potassium Trifluoroborate

blocks

BoronicAcids