2-CYANO-4-FLUOROBENZYL BROMIDE
- Product Name
- 2-CYANO-4-FLUOROBENZYL BROMIDE
- CAS No.
- 217661-27-3
- Chemical Name
- 2-CYANO-4-FLUOROBENZYL BROMIDE
- Synonyms
- 2-cyano-4-fluorobromobenzene;2-CYANO-4-FLUOROBENZYL BROMIDE;2-(broMoMethyl)-5-fluorobenzonitrile;Benzonitrile, 2-(bromomethyl)-5-fluoro-
- CBNumber
- CB01479232
- Molecular Formula
- C8H5BrFN
- Formula Weight
- 214.03
- MOL File
- 217661-27-3.mol
2-CYANO-4-FLUOROBENZYL BROMIDE Property
- Melting point:
- 64.9-65.9 °C
- Boiling point:
- 263.6±25.0 °C(Predicted)
- Density
- 1.59±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- liquid
- color
- Colourless
Safety
- HS Code
- 2926907090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- B686113
- Product name
- 2-(Bromomethyl)-5-fluorobenzonitrile
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- B686113
- Product name
- 2-(Bromomethyl)-5-fluorobenzonitrile
- Packaging
- 500mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- HCH0070345
- Product name
- 2-(BROMOMETHYL)-5-FLUOROBENZONITRILE
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $1065.66
- Updated
- 2021/12/16
- Product number
- HCH0070345
- Product name
- 2-(BROMOMETHYL)-5-FLUOROBENZONITRILE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1295.03
- Updated
- 2021/12/16
- Product number
- PC500527
- Product name
- 2-(Bromomethyl)-5-fluorobenzonitrile
- Packaging
- 1g
- Price
- $51
- Updated
- 2021/12/16
2-CYANO-4-FLUOROBENZYL BROMIDE Chemical Properties,Usage,Production
Synthesis
77532-79-7
217661-27-3
The general procedure for the synthesis of 2-(bromomethyl)-5-fluorobenzonitrile from 5-fluoro-2-methylbenzonitrile was as follows: first, 5-fluoro-2-methylbenzonitrile (28.51 g, 211 mmol), N-bromosuccinimide (NBS, 41.31 g, 232 mmol), and azobisisobutyronitrile (AIBN, 2.5 g, 15 mmol) were added to a carbon tetrachloride ( CCl4, 845 mL) in a mixture of nitrogen (N2) was passed for 10 min. Subsequently, the reaction mixture was heated to reflux for 8 hours. After completion of the reaction, the mixture was allowed to stand at room temperature overnight. On the following day, the reaction mixture was filtered and the filter cake was washed with carbon tetrachloride (500 mL). The filtrates were combined and the solvent was removed by evaporation to give a yellow oil. Finally, 2-(bromomethyl)-5-fluorobenzonitrile (29.74 g, 66% yield) was obtained as a light yellow oil using 5-25% ethyl acetate/hexane as eluent and purified by fast column chromatography on silica gel (SiO2). The structure of the product was confirmed by 1H NMR (500 MHz, CDCl3) with chemical shift δ: 7.55 (1H, dd, J = 8.6,5.2 Hz), 7.37 (1H, dd, J = 7.9,2.8 Hz), 7.32-7.28 (1H, m), 4.61 (2H, s).
References
[1] Patent: US2005/267105, 2005, A1. Location in patent: Page/Page column 63
[2] Patent: US2007/111984, 2007, A1. Location in patent: Page/Page column 29
[3] Patent: US2007/129379, 2007, A1. Location in patent: Page/Page column 22
[4] Patent: WO2007/64316, 2007, A1. Location in patent: Page/Page column 141
[5] Organic and Biomolecular Chemistry, 2013, vol. 11, # 19, p. 3128 - 3144
2-CYANO-4-FLUOROBENZYL BROMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
2-CYANO-4-FLUOROBENZYL BROMIDE Suppliers
- Tel
- 010-59484199 18611897322
- sales@eternalchem.com
- Country
- China
- ProdList
- 4383
- Advantage
- 60
- Tel
- +86057186818502 13588463833
- Fax
- Pls mail us for more information!
- info@sagechem.com
- Country
- China
- ProdList
- 10266
- Advantage
- 58
- Tel
- 021-60343070
- Fax
- 021-35122006
- Country
- China
- ProdList
- 12740
- Advantage
- 55
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 021-61317773
- Fax
- 021-61486878
- sales@aspirebio.com
- Country
- China
- ProdList
- 2880
- Advantage
- 58
- Tel
- 025-57018978 18251899859
- Fax
- 025-57018008
- sales@chalf-pharm.com
- Country
- China
- ProdList
- 5674
- Advantage
- 50
- Tel
- 13912302692 13912302692;
- Fax
- 0519-88064678
- sales@anxuanchem.com
- Country
- China
- ProdList
- 4828
- Advantage
- 58
- Tel
- 13812573443
- Fax
- -
- tongbenwan22@163.com
- Country
- China
- ProdList
- 1980
- Advantage
- 55
- Tel
- 15076683720
- Fax
- 022-23754520
- klq@cw-bio.com
- Country
- China
- ProdList
- 8011
- Advantage
- 55
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58