3-Fluoro-2-(bromomethyl)benzonitrile
- Product Name
- 3-Fluoro-2-(bromomethyl)benzonitrile
- CAS No.
- 635723-84-1
- Chemical Name
- 3-Fluoro-2-(bromomethyl)benzonitrile
- Synonyms
- 2-cyano-6-fluorobromobenzene;2-Cyano-6-fluorobenzyl bromide;3-Fluoro-2-(bromomethyl)benzonitrile;Benzonitrile, 2-(bromomethyl)-3-fluoro-
- CBNumber
- CB52498741
- Molecular Formula
- C8H5BrFN
- Formula Weight
- 214.03
- MOL File
- 635723-84-1.mol
3-Fluoro-2-(bromomethyl)benzonitrile Property
- Boiling point:
- 258℃
- Density
- 1.59
- Flash point:
- 110℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- crystals
- color
- White
Safety
- HS Code
- 2926907090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
N-Bromosuccinimide Price
- Product number
- B614910
- Product name
- 2-(Bromomethyl)-3-fluorobenzonitrile
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- B614910
- Product name
- 2-(Bromomethyl)-3-fluorobenzonitrile
- Packaging
- 500mg
- Price
- $240
- Updated
- 2021/12/16
- Product number
- FB105503
- Product name
- 2-(bromomethyl)-3-fluorobenzonitrile
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 9703AB
- Product name
- 2-(Bromomethyl)-3-fluorobenzonitrile
- Packaging
- 5g
- Price
- $432
- Updated
- 2021/12/16
- Product number
- FB105503
- Product name
- 2-(bromomethyl)-3-fluorobenzonitrile
- Packaging
- 5G
- Price
- $450
- Updated
- 2021/12/16
3-Fluoro-2-(bromomethyl)benzonitrile Chemical Properties,Usage,Production
Synthesis
185147-06-2
635723-84-1
3-Fluoro-2-methylbenzonitrile (50 g, 0.37 mol) was used as starting material and dissolved in carbon tetrachloride (500 mL). Subsequently, N-bromosuccinimide (NBS, 72.5 g, 0.408 mol) and azobisisobutyronitrile (AIBN, 1.2 g, 0.037 mol) were added to this solution. The reaction mixture was heated to reflux overnight and the progress of the reaction was monitored by thin layer chromatography (TLC), and after confirming the completion of the reaction, the reaction solution was filtered. The filtrate was concentrated under vacuum to obtain the crude product. The crude product was purified by fast silica gel column chromatography with the eluent of petroleum ether/ethyl acetate (500:1), resulting in the target compound 2-cyano-6-fluorobenzyl bromide (2B, 30 g, 40% yield) as a white solid.
References
[1] Patent: US2012/129836, 2012, A1. Location in patent: Page/Page column 12
[2] Patent: WO2013/45607, 2013, A1. Location in patent: Page/Page column 29
[3] Patent: WO2016/202253, 2016, A1. Location in patent: Page/Page column 161
3-Fluoro-2-(bromomethyl)benzonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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