ChemicalBook > CAS DataBase List > 3-Fluoro-2-(bromomethyl)benzonitrile

3-Fluoro-2-(bromomethyl)benzonitrile

Product Name: 3-Fluoro-2-(bromomethyl)benzonitrile
CAS No.: 635723-84-1
Chemical Name: 3-Fluoro-2-(bromomethyl)benzonitrile
Synonyms: 2-cyano-6-fluorobromobenzene;2-Cyano-6-fluorobenzyl bromide;3-Fluoro-2-(bromomethyl)benzonitrile;Benzonitrile, 2-(bromomethyl)-3-fluoro-
CBNumber: CB52498741
Molecular Formula: C8H5BrFN
Formula Weight: 214.03
MOL File: 635723-84-1.mol

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3-Fluoro-2-(bromomethyl)benzonitrile Property

Boiling point:: 258℃
Density: 1.59
Flash point:: 110℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: crystals
color: White

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Safety

HS Code: 2926907090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

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N-Bromosuccinimide Price

TRC

Product number: B614910
Product name: 2-(Bromomethyl)-3-fluorobenzonitrile
Packaging: 100mg
Price: $65
Updated: 2021/12/16

TRC

Product number: B614910
Product name: 2-(Bromomethyl)-3-fluorobenzonitrile
Packaging: 500mg
Price: $240
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB105503
Product name: 2-(bromomethyl)-3-fluorobenzonitrile
Packaging: 250mg
Price: $55
Updated: 2021/12/16

AK Scientific

Product number: 9703AB
Product name: 2-(Bromomethyl)-3-fluorobenzonitrile
Packaging: 5g
Price: $432
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB105503
Product name: 2-(bromomethyl)-3-fluorobenzonitrile
Packaging: 5G
Price: $450
Updated: 2021/12/16

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3-Fluoro-2-(bromomethyl)benzonitrile Chemical Properties,Usage,Production

Synthesis

185147-06-2

635723-84-1

3-Fluoro-2-methylbenzonitrile (50 g, 0.37 mol) was used as starting material and dissolved in carbon tetrachloride (500 mL). Subsequently, N-bromosuccinimide (NBS, 72.5 g, 0.408 mol) and azobisisobutyronitrile (AIBN, 1.2 g, 0.037 mol) were added to this solution. The reaction mixture was heated to reflux overnight and the progress of the reaction was monitored by thin layer chromatography (TLC), and after confirming the completion of the reaction, the reaction solution was filtered. The filtrate was concentrated under vacuum to obtain the crude product. The crude product was purified by fast silica gel column chromatography with the eluent of petroleum ether/ethyl acetate (500:1), resulting in the target compound 2-cyano-6-fluorobenzyl bromide (2B, 30 g, 40% yield) as a white solid.

References

[1] Patent: US2012/129836, 2012, A1. Location in patent: Page/Page column 12
[2] Patent: WO2013/45607, 2013, A1. Location in patent: Page/Page column 29
[3] Patent: WO2016/202253, 2016, A1. Location in patent: Page/Page column 161

3-Fluoro-2-(bromomethyl)benzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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635723-84-1, 3-Fluoro-2-(bromomethyl)benzonitrileRelated Search:

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635723-84-1

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