3,6-Dichloro-4-methylpyridazine

Product Name: 3,6-Dichloro-4-methylpyridazine
CAS No.: 19064-64-3
Chemical Name: 3,6-Dichloro-4-methylpyridazine
Synonyms: SW-104;SWF-104;BUTTPARK 47\04-25;3,6-Dichloro-4-Methy;Risdiplam Impurity 11;3,6-Dichloro-4-Methyl-pyr...;3,6-Dichloro-5-methylpyridazine;4-METHYL-3,6-DICHLOROPYRIDAZINE;3,6-DICHLORO-4-METHYLPYRIDAZINE;3,4-DICHLORO-4-METHYLPYRIDAZINE
CBNumber: CB0148072
Molecular Formula: C5H4Cl2N2
Formula Weight: 163
MOL File: 19064-64-3.mol

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3,6-Dichloro-4-methylpyridazine Property

Melting point:: 86-88 °C (lit.)
Boiling point:: 149-151 °C/21 mmHg (lit.)
Density: 1.5462 (rough estimate)
refractive index: 1.6300 (estimate)
Flash point:: 149-151°C/21mm
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: soluble in Methanol
pka: -0.56±0.10(Predicted)
form: Crystalline Powder
color: Brown
BRN: 119573
InChI: InChI=1S/C5H4Cl2N2/c1-3-2-4(6)8-9-5(3)7/h2H,1H3
InChIKey: ROYHWGZNGMXQEU-UHFFFAOYSA-N
SMILES: C1(Cl)=NN=C(Cl)C=C1C
CAS DataBase Reference: 19064-64-3(CAS DataBase Reference)
NIST Chemistry Reference: Pyridazine, 3,6-dichloro-4-methyl-(19064-64-3)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-20/21/22
Safety Statements: 26-37/39-36/37/39-22
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29339980

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 297747
Product name: 3,6-Dichloro-4-methylpyridazine
Purity: 97%
Packaging: 1g
Price: $49.9
Updated: 2023/06/20

TCI Chemical

Product number: D4206
Product name: 3,6-Dichloro-4-methylpyridazine
Purity: >98.0%(GC)
Packaging: 1g
Price: $37
Updated: 2025/07/31

TCI Chemical

Product number: D4206
Product name: 3,6-Dichloro-4-methylpyridazine
Purity: >98.0%(GC)
Packaging: 5g
Price: $129
Updated: 2025/07/31

TRC

Product number: D437238
Product name: 3,6-Dichloro-4-methylpyridazine
Packaging: 100mg
Price: $60
Updated: 2021/12/16

TRC

Product number: D437238
Product name: 3,6-Dichloro-4-methylpyridazine
Packaging: 50mg
Price: $45
Updated: 2021/12/16

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3,6-Dichloro-4-methylpyridazine Chemical Properties,Usage,Production

Chemical Properties

Brown crystalline powder.

Uses

3,6-Dichloro-4-methylpyridazine has been used in the synthesis of 7-methyl-2-phenylimidazo[1,2-b]pyridazine-3-carboxylic acid.

Application

3,6-Dichloro-4-methylpyridazine is mainly used as an intermediate in pesticides and pharmaceuticals.

Hazard

3,6-Dichloro-4-methylpyridazine causes skin irritation and serious eye irritation, it may cause respiratory irritation.

Synthesis

5754-18-7

19064-64-3

4-Methyl-1,2-dihydropyridazine-3,6-dione (9.48 g, 75.2 mmol) was suspended in phosphoryl chloride (70 mL, 750 mmol) under nitrogen protection and stirred at room temperature. Subsequently, the reaction mixture was heated to a mild reflux condition and maintained for 4 hours until a golden yellow homogeneous solution was formed. Upon completion of the reaction, the mixture was cooled and the excess trichlorophosphorus was removed by distillation under reduced pressure (14 mbar, 50-70°C). The resulting viscous brown oil was slowly added dropwise to an ice-cooled saturated sodium bicarbonate solution (200 mL) while stirring vigorously. The pH of the mixture was adjusted to 6 by batchwise addition of solid sodium bicarbonate, followed by extraction with ethyl acetate (2 x 60 mL). The organic phases were combined, washed with saturated sodium bicarbonate solution (30 mL), dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to afford 3,6-dichloro-4-methylpyridazine (11.5 g, 70.8 mmol, 94% yield) as a yellow powder. The product was recrystallized from light petroleum ether/ether and had a melting point of 87-88°C. IR spectrum (KBr, cm^-1): 3054, 1567, 1434, 1351, 1326, 1145, 1121, 914, 720. NMR hydrogen spectrum (200 MHz, CDCl3): δ 2.42 (3H, d, J = 1.0 Hz), 7.41 ( 1H, q, J = 0.9 Hz). NMR carbon spectrum (50 MHz, CDCl3): δ 19.2 (CH3), 130.1 (CH-5), 140.7 (C-4), 155.6 (C-6), 157.3 (C-3). Low resolution mass spectrum (EI): m/z 162 ([M+]). Calculated elemental analysis (C5H4Cl2N2): C, 36.84; H, 2.47; N, 17.19. Measured values: C, 36.93; H, 2.57; N, 17.48.

References

[1] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 5, p. 1644 - 1658
[2] Journal of the American Chemical Society, 1954, vol. 76, p. 2201
[3] Pharmaceutical Bulletin, 1957, vol. 5, p. 587,588
[4] Helvetica Chimica Acta, 1954, vol. 37, p. 121,131
[5] Journal of the American Chemical Society, 1954, vol. 76, p. 4454,4457

3,6-Dichloro-4-methylpyridazine Preparation Products And Raw materials

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View Lastest Price from 3,6-Dichloro-4-methylpyridazine manufacturers

Hebei Fengjia New Material Co., Ltd

Product: 3,6-Dichloro-4-methylpyridazine 19064-64-3
Price: US $2.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 100000
Release date: 2024-08-14

Hebei Chuanghai Biotechnology Co., Ltd

Product: 3,6-Dichloro-4-methylpyridazine 19064-64-3
Price: US $19.00/ASSAYS
Min. Order: 100ASSAYS
Purity: 99%
Supply Ability: 100 mt
Release date: 2024-11-20

Henan Aochuang Chemical Co.,Ltd.

Product: 3,6-Dichloro-4-methylpyridazine 19064-64-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-29

19064-64-3, 3,6-Dichloro-4-methylpyridazineRelated Search:

Dichlorodimethylsilane Dichloromethylsilane Sulfachloropyridazine sodium Dichloromethylphenylsilane Thioridazine 3,6-Dichloropyridazine Pyridazine Hydralazine 5-FLUORO-4-IODO-1H-PYRROLO[2,3-B]PYRIDINE Methyl 7-azaindole-6-carboxylate methyl 6‐bromo‐2‐oxo‐2,3‐dihydro‐1h‐indole‐4‐carboxylate 4-AMINO-1-[(2,4-DIMETHOXYPHENYL)METHYL]PYRROLIDIN-2-ONE 4-(TERT-BUTOXYCARBONYL)PHENYLBORONIC ACID 6-Chloro-5-fluoro-7-azaindole 5-FLUORO-1H-PYRROLO[2,3-B]PYRIDINE 7-BroMo-2-(Methylthio)pyrrolo[1,2-f][1,2,4]triazine 1H-Pyrrolo[2,3-b]pyridine, 3-bromo-1-[(4-methylphenyl)sulfonyl]- 7-Bromopyrido[3,2-d]pyrimidin-4(3H)-one

BUTTPARK 47\04-25

3,6-DICHLORO-4-METHYLPYRIDAZINE

4-METHYL-3,6-DICHLOROPYRIDAZINE

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3,6-Dichloro-4-methylpyridazine,97%

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3,6-<WBR>Dichloro-<WBR>4-<WBR>Methylpyridazine

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3,6-Dichloro-4-methylpyridazine&gt

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3,4-DICHLORO-4-METHYLPYRIDAZINE

3,6-Dichloro-4-methylpyridazine ISO 9001：2015 REACH

SWF-104

SW-104

Risdiplam Impurity 11

19064-64-3

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