4-Bromo-3-nitrophenol
- Product Name
- 4-Bromo-3-nitrophenol
- CAS No.
- 78137-76-5
- Chemical Name
- 4-Bromo-3-nitrophenol
- Synonyms
- 4-Bromo-3-nitrophenol;Phenol, 4-bromo-3-nitro-;4-Bromo-3-nitrophenol 95%;2-Bromo-5-hydroxynitrobenzene;4-Bromo-3-nitrophenol ISO 9001：2015 REACH;2-Bromo-5-hydroxynitrobenzene, 1-Bromo-4-hydroxy-2-nitrobenzene
- CBNumber
- CB01481941
- Molecular Formula
- C6H4BrNO3
- Formula Weight
- 218
- MOL File
- 78137-76-5.mol
4-Bromo-3-nitrophenol Property
- Melting point:
- 144-145 ºC
- Boiling point:
- 281 ºC
- Density
- 1.881
- Flash point:
- 124 ºC
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- pka
- 7.65±0.10(Predicted)
- color
- Very dark orange/brown
Safety
- HS Code
- 2908990000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H317May cause an allergic skin reaction
H318Causes serious eye damage
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P272Contaminated work clothing should not be allowed out of the workplace.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P391Collect spillage. Hazardous to the aquatic environment
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B698020
- Product name
- 4-Bromo-3-nitrophenol
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- J51152
- Product name
- 4-Bromo-3-nitrophenol
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
- Product number
- W8436
- Product name
- 4-Bromo-3-nitrophenol
- Packaging
- 1g
- Price
- $14
- Updated
- 2021/12/16
- Product number
- 072569
- Product name
- 4-Bromo-3-nitrophenol
- Purity
- 95+%
- Packaging
- 1g
- Price
- $29
- Updated
- 2021/12/16
- Product number
- CS-W008975
- Product name
- 2-Bromo-5-hydroxynitrobenzene
- Purity
- 99.33%
- Packaging
- 5g
- Price
- $30
- Updated
- 2021/12/16
4-Bromo-3-nitrophenol Chemical Properties,Usage,Production
Chemical Properties
brown solid
Synthesis
5344-78-5
78137-76-5
Step 1. Synthesis of 4-bromo-3-nitrophenol (C3). 1-Bromo-4-methoxy-2-nitrobenzene (170 g, 0.73 mol) was dissolved in dichloromethane (1.5 L) under argon protection in a 5 L three-necked round-bottomed flask equipped with a thermometer, a pressure equalizing dropping funnel, and an exhaust gas scrubber (1 M aqueous sodium hydroxide solution). The reaction system was cooled to -78 °C. Another boron tribromide (176 mL, 1.86 mol) was dissolved in pre-cooled dichloromethane (1.6 L, 0 °C) and slowly added to the reaction system through the dropping funnel over a period of 2 h. The temperature was raised to -55 °C during the reaction. After addition, the cooling bath was removed and the reaction system was allowed to warm slowly to room temperature with continuous stirring for 48 hours. Subsequently, the reaction mixture was slowly added to cold water (2.0 L, ice/water bath) through a dropping funnel over a period of 4 h. The internal temperature was controlled to be lower than 20 °C, while the generated HBr gas was absorbed using a scrubber (1 M aqueous sodium hydroxide solution). After quenching, the mixture was continued to be stirred for 1 h at room temperature, partitioned and the aqueous layer was extracted with EtOAc (2.0 L). The organic layers (dichloromethane and EtOAc) were combined, washed sequentially with saturated aqueous sodium bicarbonate (2 x 1.2 L; organic layer as lower phase) and brine (1 L; aqueous layer as lower phase), dried over magnesium sulfate and concentrated under reduced pressure. The residue was suspended in dichloromethane (320 mL), slurried overnight, and the solid was collected by filtration. The solid was dissolved in aqueous sodium hydroxide (2.0 M, 500 mL) and extracted with dichloromethane (500 mL). The dichloromethane layer was then extracted with aqueous sodium hydroxide (250 mL), and the combined aqueous layers were acidified with aqueous HCl (1.0 M, 790 mL) to pH 2. The precipitate precipitated was filtered and dried under vacuum at 40 °C for 18 h to afford the target product C3 (125.5 g, 0.5757 mol, 79% yield).1H NMR (400 MHz, CD3OD) δ 6.95 (dd, J = 8.8, 2.9 Hz, 1H), 7.24 (d, J = 2.9 Hz, 1H), 7.57 (d, J = 8.8 Hz, 1H).
References
[1] Patent: US2007/78147, 2007, A1. Location in patent: Page/Page column 68
[2] Patent: WO2007/56582, 2007, A1. Location in patent: Page/Page column 77-78
[3] Tetrahedron Letters, 2011, vol. 52, # 26, p. 3376 - 3378
[4] Patent: WO2012/73146, 2012, A1. Location in patent: Page/Page column 24-25
[5] Tetrahedron Letters, 1996, vol. 37, # 40, p. 7189 - 7192
4-Bromo-3-nitrophenol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Bromo-3-nitrophenol manufacturers
- Product
- 4-Bromo-3-nitrophenol 78137-76-5
- Price
- US $101.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-28
- Product
- 4-Bromo-3-nitrophenol 78137-76-5
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 100 tons
- Release date
- 2020-01-10
- Product
- 4-Bromo-3-nitrophenol 78137-76-5
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-24