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4-Bromo-3-nitrophenol

Product Name
4-Bromo-3-nitrophenol
CAS No.
78137-76-5
Chemical Name
4-Bromo-3-nitrophenol
Synonyms
4-Bromo-3-nitrophenol;Phenol, 4-bromo-3-nitro-;4-Bromo-3-nitrophenol 95%;2-Bromo-5-hydroxynitrobenzene;4-Bromo-3-nitrophenol ISO 9001：2015 REACH;2-Bromo-5-hydroxynitrobenzene, 1-Bromo-4-hydroxy-2-nitrobenzene
CBNumber
CB01481941
Molecular Formula
C6H4BrNO3
Formula Weight
218
MOL File
78137-76-5.mol
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4-Bromo-3-nitrophenol Property

Melting point:
144-145 ºC
Boiling point:
281 ºC
Density 
1.881
Flash point:
124 ºC
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
solid
pka
7.65±0.10(Predicted)
color 
Very dark orange/brown
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Safety

HS Code 
2908990000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H318Causes serious eye damage

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
B698020
Product name
4-Bromo-3-nitrophenol
Packaging
1g
Price
$75
Updated
2021/12/16
ChemScene
Product number
CS-W008975
Product name
2-Bromo-5-hydroxynitrobenzene
Purity
99.33%
Packaging
25g
Price
$88
Updated
2021/12/16
Matrix Scientific
Product number
072569
Product name
4-Bromo-3-nitrophenol
Purity
95+%
Packaging
5g
Price
$108
Updated
2021/12/16
SynQuest Laboratories
Product number
4654-9-43
Product name
4-Bromo-3-nitrophenol
Purity
98%
Packaging
25g
Price
$135
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB139823
Product name
4-Bromo-3-nitrophenol
Packaging
5G
Price
$143
Updated
2021/12/16
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4-Bromo-3-nitrophenol Chemical Properties,Usage,Production

Chemical Properties

brown solid

Synthesis

5344-78-5

78137-76-5

Step 1. Synthesis of 4-bromo-3-nitrophenol (C3). 1-Bromo-4-methoxy-2-nitrobenzene (170 g, 0.73 mol) was dissolved in dichloromethane (1.5 L) under argon protection in a 5 L three-necked round-bottomed flask equipped with a thermometer, a pressure equalizing dropping funnel, and an exhaust gas scrubber (1 M aqueous sodium hydroxide solution). The reaction system was cooled to -78 °C. Another boron tribromide (176 mL, 1.86 mol) was dissolved in pre-cooled dichloromethane (1.6 L, 0 °C) and slowly added to the reaction system through the dropping funnel over a period of 2 h. The temperature was raised to -55 °C during the reaction. After addition, the cooling bath was removed and the reaction system was allowed to warm slowly to room temperature with continuous stirring for 48 hours. Subsequently, the reaction mixture was slowly added to cold water (2.0 L, ice/water bath) through a dropping funnel over a period of 4 h. The internal temperature was controlled to be lower than 20 °C, while the generated HBr gas was absorbed using a scrubber (1 M aqueous sodium hydroxide solution). After quenching, the mixture was continued to be stirred for 1 h at room temperature, partitioned and the aqueous layer was extracted with EtOAc (2.0 L). The organic layers (dichloromethane and EtOAc) were combined, washed sequentially with saturated aqueous sodium bicarbonate (2 x 1.2 L; organic layer as lower phase) and brine (1 L; aqueous layer as lower phase), dried over magnesium sulfate and concentrated under reduced pressure. The residue was suspended in dichloromethane (320 mL), slurried overnight, and the solid was collected by filtration. The solid was dissolved in aqueous sodium hydroxide (2.0 M, 500 mL) and extracted with dichloromethane (500 mL). The dichloromethane layer was then extracted with aqueous sodium hydroxide (250 mL), and the combined aqueous layers were acidified with aqueous HCl (1.0 M, 790 mL) to pH 2. The precipitate precipitated was filtered and dried under vacuum at 40 °C for 18 h to afford the target product C3 (125.5 g, 0.5757 mol, 79% yield).1H NMR (400 MHz, CD3OD) δ 6.95 (dd, J = 8.8, 2.9 Hz, 1H), 7.24 (d, J = 2.9 Hz, 1H), 7.57 (d, J = 8.8 Hz, 1H).

References

[1] Patent: US2007/78147, 2007, A1. Location in patent: Page/Page column 68
[2] Patent: WO2007/56582, 2007, A1. Location in patent: Page/Page column 77-78
[3] Tetrahedron Letters, 2011, vol. 52, # 26, p. 3376 - 3378
[4] Patent: WO2012/73146, 2012, A1. Location in patent: Page/Page column 24-25
[5] Tetrahedron Letters, 1996, vol. 37, # 40, p. 7189 - 7192

4-Bromo-3-nitrophenol Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Bromo-3-nitrophenol Suppliers

China 86 Germany 1 India 1 United Kingdom 2 United States 10 Global 100
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Shijiazhuang Sdyano Fine Chemical Co., Ltd.
Tel
0311-89250318 031166536426
Fax
4000311741
Email
master@sjzsdyn.com
Country
China
ProdList
2807
Advantage
65
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Tetranov Biopharm
Tel
13526569071
Email
sales@leadmedpharm.com
Country
China
ProdList
7892
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
PSN Pharmaceutical Technology Co., Ltd.
Tel
86-25-57062118
Fax
86-25-57065896
Email
sales@jspsn.com
Country
China
ProdList
496
Advantage
57
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18729
Advantage
57
Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel
18270980682
Fax
021 51613951
Email
mlcheng@sunwaypharm.cn
Country
China
ProdList
8669
Advantage
57
NovoChemy Ltd.
Tel
021-31261262/ 49 (0)17662837245
Fax
(0)21-33250524
Email
sales@novochemy.com
Country
Germany
ProdList
6328
Advantage
58
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9510
Advantage
58
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View Lastest Price from 4-Bromo-3-nitrophenol manufacturers

Henan Fengda Chemical Co., Ltd
Product
4-Bromo-3-nitrophenol 78137-76-5
Price
US $101.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-28
Shaanxi Dideu Medichem Co. Ltd
Product
4-Bromo-3-nitrophenol 78137-76-5
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%
Supply Ability
100 tons
Release date
2020-01-10
Career Henan Chemical Co
Product
4-Bromo-3-nitrophenol 78137-76-5
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-24

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  • 4-Bromo-3-nitrophenol ISO 9001：2015 REACH
  • 78137-76-5