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ChemicalBook > CAS DataBase List > 2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE

2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE

Uses
Product Name
2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE
CAS No.
846023-24-3
Chemical Name
2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE
Synonyms
SKL780;Bosutinib Impurity 29;N-(2,4-Dichloro-5-methoxyphenyl)-2-cyanoacetamide;2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE;AcetaMide,2-cyano-N-(2,4-dichloro-5-Methoxyphenyl)-
CBNumber
CB01482463
Molecular Formula
C10H8Cl2N2O2
Formula Weight
259.09
MOL File
846023-24-3.mol
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2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE Property

Melting point:
180-181 °C(Solv: ethyl acetate (141-78-6))
Boiling point:
462.4±45.0 °C(Predicted)
Density 
1.436±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
-1.71±0.10(Predicted)
Appearance
White to off-white Solid
InChI
InChI=1S/C10H8Cl2N2O2/c1-16-9-5-8(6(11)4-7(9)12)14-10(15)2-3-13/h4-5H,2H2,1H3,(H,14,15)
InChIKey
RPWHAQJEZWBZGX-UHFFFAOYSA-N
SMILES
C(NC1=CC(OC)=C(Cl)C=C1Cl)(=O)CC#N
CAS DataBase Reference
846023-24-3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
FC149891
Product name
2-Cyano-N-(2,4-dichloro-5-methoxyphenyl)acetamide
Packaging
50mg
Price
$62
Updated
2021/12/16
AK Scientific
Product number
3010AC
Product name
2-Cyano-N-(2,4-dichloro-5-methoxyphenyl)acetamide
Packaging
250mg
Price
$74
Updated
2021/12/16
AK Scientific
Product number
3010AC
Product name
2-Cyano-N-(2,4-dichloro-5-methoxyphenyl)acetamide
Packaging
1g
Price
$85
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC149891
Product name
2-Cyano-N-(2,4-dichloro-5-methoxyphenyl)acetamide
Packaging
100mg
Price
$107
Updated
2021/12/16
AK Scientific
Product number
3010AC
Product name
2-Cyano-N-(2,4-dichloro-5-methoxyphenyl)acetamide
Packaging
5g
Price
$139
Updated
2021/12/16
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2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE Chemical Properties,Usage,Production

Uses

2-cyano-N-(2,4-dichloro-5-methoxyphenyl)acetamide (cas# 846023-24-3) is a useful research chemical.

Chemical Properties

Pale yellow powder

Synthesis

98446-49-2

372-09-8

846023-24-3

Example 4 Synthesis of 2-cyano-N-(2,4-dichloro-5-methoxyphenyl)acetamide: 2,4-dichloro-5-methoxyaniline (5.00 g, 26 mmol) was mixed with cyanoacetic acid (2.28 g, 26.8 mmol) at 50 °C. Tetrahydrofuran was added to the mixture until complete dissolution. Subsequently, the solution was heated to reflux and 1,3-diisopropylcarbodiimide (4.2 mL, 26.8 mmol) was added slowly and dropwise. After 30 minutes of reaction, the reaction mixture was cooled to about 15 °C in an ice bath. The solid product formed was collected by filtration and washed with tetrahydrofuran. The filtrate was slowly poured into water and stirred for 30 minutes. The white solid product was collected by filtration again, washed with water and dissolved in 500 mL of ethyl acetate. The resulting solution was dried over anhydrous sodium sulfate and subsequently concentrated under vacuum to afford 5.9 g (88% yield) of the target compound 2-cyano-N-(2,4-dichloro-5-methoxyphenyl)acetamide as a white solid with a melting point of 180-181 °C.1H NMR (400 MHz, DMSO-d6) δ 3.84 (s, 3H), 4.02 (s, 2H) 7.58 (s, 1H), 7.66 (s, 1H), 10.00 (s, 1H); mass spectra (electrospray ionization) m/z 257.0, 259.0 ([M-H]-). Elemental analysis (C10H8Cl2N2O2) calculated values: C, 46.36; H, 3.11; N, 10.81. measured values: C, 46.25; H, 3.10; N, 10.85.

References

[1] Journal of Medicinal Chemistry, 2006, vol. 49, # 26, p. 7868 - 7876
[2] Patent: US2005/43537, 2005, A1. Location in patent: Page/Page column 3; 6
[3] Patent: WO2006/47262, 2006, A1. Location in patent: Page/Page column 13-14
[4] Letters in Drug Design and Discovery, 2011, vol. 8, # 1, p. 9 - 13

2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE Suppliers

China 109 Germany 1 India 5 South Korea 1 United Kingdom 1 United States 5 Global 122
Pharmaffiliates Analytics and Synthetics P. Ltd
Tel
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Email
mktg@pharmaffiliates.com
Country
India
ProdList
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A.J Chemicals
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sales@ajchem.in
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India
ProdList
6100
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View Lastest Price from 2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE 846023-24-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-30
Career Henan Chemical Co
Product
2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE 864023-24-3
Price
US $1.00/g
Min. Order
1g
Purity
99.99%
Supply Ability
200kg
Release date
2019-12-23
Career Henan Chemical Co
Product
2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE 846023-24-3
Price
US $150.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200KG
Release date
2018-07-30

846023-24-3, 2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDERelated Search:

Bosutinib Impurity 15 Bosutinib Impurity Deionized water 5-Amino-2,4-dichloroanisole 2-aMino-4-(3-chloropropoxy)-5-Methoxybenzoate 4-CHLORO-7-(3-CHLORO-PROPOXY)-6-METHOXY-QUINOLINE-3-CARBONITRILE Methyl 4-(3-chloropropoxy)-5-Methoxy-2-nitrobenzoate 7-(3-CHLORO-PROPOXY)-4-(2,4-DICHLORO-5-METHOXY-PHENYLAMINO)-6-METHOXY-QUINOLINE-3-CARBONITRILE Bosutinib Bosutinib Monohydrate 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-7-fluoro-6-methoxy-3-quinolinecarbonitrile 3-Quinolinecarbonitrile, 7-(3-chloropropoxy)-4-hydroxy-6-Methoxy- 1-[3-(2-Methoxy-5-nitrophenoxy)propyl]-4-Methylpiperazine N-(2,4-DICHLORO-5-HYDROXYPHENYL)ACETAMIDE 4-Methoxy-3-(3-(4-Methylpiperazin-1-yl)propoxy)aniline 4-CHLORO-7-FLUORO-6-METHOXY-QUINOLINE-3-CARBONITRILE 4-CHLORO-7-HYDROXY-6-METHOXY-QUINOLINE-3-CARBONITRILE Bosutinib Impurity 6

  • 2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE
  • AcetaMide,2-cyano-N-(2,4-dichloro-5-Methoxyphenyl)-
  • Bosutinib Impurity 29
  • N-(2,4-Dichloro-5-methoxyphenyl)-2-cyanoacetamide
  • SKL780
  • 846023-24-3
  • 46023-24-3
  • 864023-24-3