(5-CHLORO-2-METHOXYPHENYL)ACETONITRILE
- Product Name
- (5-CHLORO-2-METHOXYPHENYL)ACETONITRILE
- CAS No.
- 7048-38-6
- Chemical Name
- (5-CHLORO-2-METHOXYPHENYL)ACETONITRILE
- Synonyms
- 5-Chloro-2-methoxybenzeneacetonitrile;Benzeneacetonitrile, 5-chloro-2-methoxy-;2-(5-chloro-2-Methoxyphenyl)acetonitrile
- CBNumber
- CB01489169
- Molecular Formula
- C9H8ClNO
- Formula Weight
- 181.62
- MOL File
- 7048-38-6.mol
(5-CHLORO-2-METHOXYPHENYL)ACETONITRILE Property
- Melting point:
- 63 °C(Solv: water (7732-18-5); ethanol (64-17-5))
- Boiling point:
- 138-140 °C(Press: 1 Torr)
- Density
- 1.198±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2926907090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C374538
- Product name
- (5-chloro-2-methoxyphenyl)acetonitrile
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FC139752
- Product name
- (5-Chloro-2-methoxyphenyl)acetonitrile
- Packaging
- 500mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- FC139752
- Product name
- (5-Chloro-2-methoxyphenyl)acetonitrile
- Packaging
- 1g
- Price
- $119
- Updated
- 2021/12/16
- Product number
- FC139752
- Product name
- (5-Chloro-2-methoxyphenyl)acetonitrile
- Packaging
- 2g
- Price
- $207
- Updated
- 2021/12/16
- Product number
- 0911AC
- Product name
- (5-Chloro-2-methoxyphenyl)acetonitrile
- Packaging
- 1g
- Price
- $215
- Updated
- 2021/12/16
(5-CHLORO-2-METHOXYPHENYL)ACETONITRILE Chemical Properties,Usage,Production
Synthesis
773837-37-9
7035-11-2
7048-38-6
The general procedure for the synthesis of 5-chloro-2-methoxyphenylacetonitrile from the compound (CAS: 773837-37-9) and 4-chloro-2-(chloromethyl)-1-methoxybenzene was as follows: compound Z-0-6 (32 g, 168 mmol) was dissolved in dimethyl sulfoxide (DMSO, 200 mL). Subsequently, sodium cyanide (29 g, 606 mmol) was added to the solution. The reaction mixture was heated to 80 °C under nitrogen protection and maintained at this temperature for 3 hours. Upon completion of the reaction, the mixture was cooled to room temperature, dispersed by the addition of water, and the product was subsequently separated by diafiltration. The filter cake was washed with a small amount of water and dried to give Z-0-7 (31 g, yield: 98.3%) as an orange-red solid.
References
[1] Patent: CN106243003, 2016, A. Location in patent: Paragraph 0130; 0131; 0136
[2] Patent: US2016/130239, 2016, A1. Location in patent: Paragraph 0735; 0739
[3] Patent: WO2014/151472, 2014, A1. Location in patent: Paragraph 00398-00399
[4] Patent: WO2016/40315, 2016, A1. Location in patent: Paragraph 00441; 00442
[5] Journal of Medicinal Chemistry, 2017, vol. 60, # 16, p. 7029 - 7042
(5-CHLORO-2-METHOXYPHENYL)ACETONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
(5-CHLORO-2-METHOXYPHENYL)ACETONITRILE Suppliers
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- Country
- United Kingdom
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- 6005
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