TERT-BUTYL 3-HYDROXY-4-PHENYLPIPERIDINE-1-CARBOXYLATE

Product Name: TERT-BUTYL 3-HYDROXY-4-PHENYLPIPERIDINE-1-CARBOXYLATE
CAS No.: 1000931-04-3
Chemical Name: TERT-BUTYL 3-HYDROXY-4-PHENYLPIPERIDINE-1-CARBOXYLATE
Synonyms: 1-Boc-3-Hydroxy-4-phenylpiperidine;TERT-BUTYL 3-HYDROXY-4-PHENYLPIPERIDINE-1-CARBOXYLATE;3-Hydroxy-4-phenyl-1-piperidinecarboxylic acid 1,1-dimethylethyl ester;1-Piperidinecarboxylic acid, 3-hydroxy-4-phenyl-, 1,1-dimethylethyl ester
CBNumber: CB01490770
Molecular Formula: C16H23NO3
Formula Weight: 277.36
MOL File: 1000931-04-3.mol

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TERT-BUTYL 3-HYDROXY-4-PHENYLPIPERIDINE-1-CARBOXYLATE Property

Boiling point:: 402.6±45.0 °C(Predicted)
Density: 1.128±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 14.48±0.40(Predicted)
Appearance: Light yellow to light brown Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H303May be harmfulif swallowed

H320Causes eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC

Product number: T204905
Product name: tert-Butyl3-Hydroxy-4-phenylpiperidine-1-carboxylate
Packaging: 10mg
Price: $45
Updated: 2021/12/16

TRC

Product number: T204905
Product name: tert-Butyl3-Hydroxy-4-phenylpiperidine-1-carboxylate
Packaging: 100mg
Price: $310
Updated: 2021/12/16

AK Scientific

Product number: 0087AA
Product name: 1-Boc-3-Hydroxy-4-phenylpiperidine
Packaging: 100mg
Price: $311
Updated: 2021/12/16

AK Scientific

Product number: 0087AA
Product name: 1-Boc-3-Hydroxy-4-phenylpiperidine
Packaging: 1g
Price: $798
Updated: 2021/12/16

Matrix Scientific

Product number: 115464
Product name: tert-Butyl 3-hydroxy-4-phenylpiperidine-1-carboxylate
Purity: 95+%
Packaging: 500mg
Price: $983
Updated: 2021/12/16

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TERT-BUTYL 3-HYDROXY-4-PHENYLPIPERIDINE-1-CARBOXYLATE Chemical Properties,Usage,Production

Synthesis

100-59-4

161157-50-2

1000931-04-3

The general procedure for the synthesis of N-BOC-3-hydroxy-4-phenylpiperidine from phenylmagnesium chloride and tert-butyl 7-oxa-3-azabicyclo[4.1.0]heptane-3-carboxylate was as follows: referring to the method of Tetrahedron Lett., 1979, 17, 1503, to a stirred tetrahydrofuran (THF, 3 mL) solution of phenylmagnesium chloride (0.753 mL, 1.51 mmol) and copper(I) iodide (0.0191 g, 0.100 mmol) solution of tetrahydrofuran (THF, 3 mL), a THF (1 mL) solution of tert-butyl 7-oxa-3-azabicyclo[4.1.0]heptane-3-carboxylate (0.200 g, 1.00 mmol) was slowly added. The reaction mixture was gradually warmed to room temperature and stirred continuously for 16 hours. Upon completion of the reaction, the reaction was quenched with saturated aqueous ammonium chloride solution, followed by extraction of the mixture with ethyl acetate (AcOEt). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated in vacuum to afford tert-butyl 3-hydroxy-4-phenylpiperidine-1-carboxylate (0.261 g, 94% yield) as an oil. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 1.49 (s, 9H), 1.76 (m, 3H), 2.50-2.78 (m, 3H), 3.70 (m, 1H), 4.30 (bd, 1H), 7.30 (m, 5H).

References

[1] Patent: WO2008/11130, 2008, A2. Location in patent: Page/Page column 136-137

TERT-BUTYL 3-HYDROXY-4-PHENYLPIPERIDINE-1-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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TERT-BUTYL 3-HYDROXY-4-PHENYLPIPERIDINE-1-CARBOXYLATE Suppliers

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1000931-04-3, TERT-BUTYL 3-HYDROXY-4-PHENYLPIPERIDINE-1-CARBOXYLATERelated Search:

tert-butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine-1-carboxylate TERT-BUTYL 4-(4-BROMOPHENYL)-4-CYANOPIPERIDINE-1-CARBOXYLATE 1-N-BOC-4-PHENYLPIPERIDINE-4-CARBONITRILE 3-(1-(TERT-BUTOXYCARBONYL)PIPERIDIN-4-YL)BENZOIC ACID 1-N-BOC-4-HYDROXY-4-PHENYLPIPERIDINE BOC-4-(4-BROMOPHENYL)-PIPERIDINE-4-CARBOXYLIC ACID 1-N-BOC-4-AMINOMETHYL-4-PHENYLPIPERIDINE tert-Butyl 4-aMino-4-(4-broMophenyl)piperidine-1-carboxylate 4-(3-BROMO-PHENYL)-1-N-BOC-PIPERIDINE

TERT-BUTYL 3-HYDROXY-4-PHENYLPIPERIDINE-1-CARBOXYLATE

1-Boc-3-Hydroxy-4-phenylpiperidine

1-Piperidinecarboxylic acid, 3-hydroxy-4-phenyl-, 1,1-dimethylethyl ester

3-Hydroxy-4-phenyl-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

1000931-04-3