TERT-BUTYL 3-HYDROXY-4-PHENYLPIPERIDINE-1-CARBOXYLATE
- Product Name
- TERT-BUTYL 3-HYDROXY-4-PHENYLPIPERIDINE-1-CARBOXYLATE
- CAS No.
- 1000931-04-3
- Chemical Name
- TERT-BUTYL 3-HYDROXY-4-PHENYLPIPERIDINE-1-CARBOXYLATE
- Synonyms
- 1-Boc-3-Hydroxy-4-phenylpiperidine;TERT-BUTYL 3-HYDROXY-4-PHENYLPIPERIDINE-1-CARBOXYLATE;3-Hydroxy-4-phenyl-1-piperidinecarboxylic acid 1,1-dimethylethyl ester;1-Piperidinecarboxylic acid, 3-hydroxy-4-phenyl-, 1,1-dimethylethyl ester
- CBNumber
- CB01490770
- Molecular Formula
- C16H23NO3
- Formula Weight
- 277.36
- MOL File
- 1000931-04-3.mol
TERT-BUTYL 3-HYDROXY-4-PHENYLPIPERIDINE-1-CARBOXYLATE Property
- Boiling point:
- 402.6±45.0 °C(Predicted)
- Density
- 1.128±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 14.48±0.40(Predicted)
- Appearance
- Light yellow to light brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H303May be harmfulif swallowed
H320Causes eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- T204905
- Product name
- tert-Butyl3-Hydroxy-4-phenylpiperidine-1-carboxylate
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- T204905
- Product name
- tert-Butyl3-Hydroxy-4-phenylpiperidine-1-carboxylate
- Packaging
- 100mg
- Price
- $310
- Updated
- 2021/12/16
- Product number
- 0087AA
- Product name
- 1-Boc-3-Hydroxy-4-phenylpiperidine
- Packaging
- 100mg
- Price
- $311
- Updated
- 2021/12/16
- Product number
- 0087AA
- Product name
- 1-Boc-3-Hydroxy-4-phenylpiperidine
- Packaging
- 1g
- Price
- $798
- Updated
- 2021/12/16
- Product number
- 115464
- Product name
- tert-Butyl 3-hydroxy-4-phenylpiperidine-1-carboxylate
- Purity
- 95+%
- Packaging
- 500mg
- Price
- $983
- Updated
- 2021/12/16
TERT-BUTYL 3-HYDROXY-4-PHENYLPIPERIDINE-1-CARBOXYLATE Chemical Properties,Usage,Production
Synthesis
100-59-4
161157-50-2
1000931-04-3
The general procedure for the synthesis of N-BOC-3-hydroxy-4-phenylpiperidine from phenylmagnesium chloride and tert-butyl 7-oxa-3-azabicyclo[4.1.0]heptane-3-carboxylate was as follows: referring to the method of Tetrahedron Lett., 1979, 17, 1503, to a stirred tetrahydrofuran (THF, 3 mL) solution of phenylmagnesium chloride (0.753 mL, 1.51 mmol) and copper(I) iodide (0.0191 g, 0.100 mmol) solution of tetrahydrofuran (THF, 3 mL), a THF (1 mL) solution of tert-butyl 7-oxa-3-azabicyclo[4.1.0]heptane-3-carboxylate (0.200 g, 1.00 mmol) was slowly added. The reaction mixture was gradually warmed to room temperature and stirred continuously for 16 hours. Upon completion of the reaction, the reaction was quenched with saturated aqueous ammonium chloride solution, followed by extraction of the mixture with ethyl acetate (AcOEt). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated in vacuum to afford tert-butyl 3-hydroxy-4-phenylpiperidine-1-carboxylate (0.261 g, 94% yield) as an oil. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 1.49 (s, 9H), 1.76 (m, 3H), 2.50-2.78 (m, 3H), 3.70 (m, 1H), 4.30 (bd, 1H), 7.30 (m, 5H).
References
[1] Patent: WO2008/11130, 2008, A2. Location in patent: Page/Page column 136-137