3,6-DICHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID
- Product Name
- 3,6-DICHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID
- CAS No.
- 34576-94-8
- Chemical Name
- 3,6-DICHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID
- Synonyms
- BT2;BT2, 10 mM in DMSO;3,6-DICHLORO-BENZO[B]THIOPHENE-2-CARBOXY;Bcl-2 Family,BT2,Inhibitor,BT-2,inhibit,BT 2;3,6-dichlorobenzothiophene-2-carboxylic acid;3,6-dichloro-2-benzothiophenecarboxylic acid;3,6-Dichloro-1-benzothiophene-2-carboxylicaci;3,6-Dichlorobenzo[β]thiophene-2-carboxylic acid;Benzo[b]thiophene-2-carboxylic acid, 3,6-dichloro-;JR-6478, 3,6-Dichlorobenzo[b]thiophene-2-carboxylic acid, 97%
- CBNumber
- CB01492789
- Molecular Formula
- C9H4Cl2O2S
- Formula Weight
- 247.1
- MOL File
- 34576-94-8.mol
3,6-DICHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID Property
- Boiling point:
- 426.4±40.0 °C(Predicted)
- Density
- 1.653±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Soluble in DMSO (up to at least 20 mg/ml)
- pka
- 2.09±0.30(Predicted)
- form
- solid
- color
- Off-white
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 22948
- Product name
- 3,6-dichloro-benzo[b]thiophene-2-Carboxylic Acid
- Purity
- ≥95%
- Packaging
- 100mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 22948
- Product name
- 3,6-dichloro-benzo[b]thiophene-2-Carboxylic Acid
- Purity
- ≥95%
- Packaging
- 250mg
- Price
- $63
- Updated
- 2024/03/01
- Product number
- 22948
- Product name
- 3,6-dichloro-benzo[b]thiophene-2-Carboxylic Acid
- Purity
- ≥95%
- Packaging
- 500mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- COR0002384
- Product name
- 3,6-DICHLOROBENZO[B]THIOPHENE-2-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $721.57
- Updated
- 2021/12/16
- Product number
- FD57151
- Product name
- 3,6-Dichlorobenzo[b]thiophene-2-carboxylic acid
- Packaging
- 2g
- Price
- $450
- Updated
- 2021/12/16
3,6-DICHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID Chemical Properties,Usage,Production
Description
3,6-dichloro-benzo[b]thiophene-2-Carboxylic acid is an inhibitor of myeloid cell leukemia 1 (Mcl-1) with a Ki value of 59 μM for binding of FITC-Mcl-1-BH2 peptide binding to Mcl-1. It has been used as a building block in the synthesis of inhibitors of Mcl-1, the toll-like receptor 3/double-stranded RNA (TLR3/dsRNA) complex, and D-amino acid oxidase (DAO).
References
1) Tso et al. (2014), Benzothiophene carboxylate derivatives as novel allosteric inhibitors of branched-chain α-ketoacid dehydrogenase kinase; J. Biol. Chem., 289 20583 2) Friberg et al. (2013), Discovery of potent myeloid cell leukemia (Mcl 1) inhibitors using fragment based methods and structure based design; J. Med. Chem. 56 15
3,6-DICHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3,6-DICHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID manufacturers
- Product
- 3,6-DICHLORO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID 34576-94-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 96%
- Supply Ability
- 500kg
- Release date
- 2018-08-20