4-IODO-1-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID
Uses- Product Name
- 4-IODO-1-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID
- CAS No.
- 75092-30-7
- Chemical Name
- 4-IODO-1-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID
- Synonyms
- 4-Iodo-1-methylpyrazole-5-carboxylic Acid;4-iodo-2-methylpyrazole-3-carboxylic acid;4-Iodo-1-methylpyrazole-5-carboxylicAcid>4-IODO-1-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID;4-Iodo--1-methyl-1H-pyrazol-5-carboxylic acid;1H-Pyrazole-5-carboxylic acid, 4-iodo-1-methyl-;4-Iodo-1-methyl-1H-pyrazole-5-carboxylicacid98%;4-Iodo-1-methyl-1H-pyrazole-5-carboxylic acid 98%;4-iodo-1-methyl-1H-pyrazole-5-carboxylic acid(SALTDATA: FREE);5-Carboxy-4-iodo-1-methyl-1H-pyrazole, 4-Iodo-2-methyl-2H-pyrazole-3-carboxylic acid
- CBNumber
- CB01495720
- Molecular Formula
- C5H5IN2O2
- Formula Weight
- 252.01
- MOL File
- 75092-30-7.mol
4-IODO-1-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID Property
- Melting point:
- 242°C(lit.)
- Boiling point:
- 362.2±27.0 °C(Predicted)
- Density
- 2.26±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- form
- powder to crystal
- pka
- 1.76±0.37(Predicted)
- color
- White to Almost white
- CAS DataBase Reference
- 75092-30-7
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933199090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- R432733
- Product name
- 4-IODO-2-METHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID
- Purity
- AldrichCPR
- Packaging
- 50MG
- Price
- $30.7
- Updated
- 2025/07/31
- Product number
- I0786
- Product name
- 4-Iodo-1-methylpyrazole-5-carboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $64
- Updated
- 2025/07/31
- Product number
- I0786
- Product name
- 4-Iodo-1-methylpyrazole-5-carboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $323
- Updated
- 2025/07/31
- Product number
- I737028
- Product name
- 4-Iodo-1-methyl-1H-pyrazole-5-carboxylicAcid
- Packaging
- 500mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- OR16973
- Product name
- 4-Iodo-1-methyl-1H-pyrazole-5-carboxylicacid
- Purity
- 98%
- Packaging
- 5g
- Price
- $218
- Updated
- 2021/12/16
4-IODO-1-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID Chemical Properties,Usage,Production
Uses
4-Iodo-1-methyl-1H-pyrazole-5-carboxylic acid is a carboxylic acid derivative that can be used as a pharmaceutical intermediate.
Synthesis
1354705-42-2
75092-30-7
General procedure for the synthesis of 4-iodo-1-methyl-1H-pyrazole-5-carboxylic acid from ethyl 4-iodo-1-methyl-1H-pyrazole-5-carboxylate: to a stirred solution of ethyl 4-iodo-1-methyl-1H-pyrazole-5-carboxylate (700 mg, 2.5 mmol) in a solvent mixture of 15 mL MeOH/H2O/THF (v/v/v = 1:1:1) Lithium hydroxide monohydrate (1.05 g, 25 mmol) was added. After addition, the reaction solution was stirred at 25°C for 2 hours. After the completion of the reaction, the mixture was concentrated under reduced pressure and the pH was adjusted to 4 with 1N HCl. The aqueous phase was extracted with EtOAc, and the organic layers were combined, washed with saturated brine, dried over anhydrous Na2SO4, and concentrated under reduced pressure to obtain the crude 4-iodo-1-methyl-1H-pyrazole-5-carboxylic acid (623.0 mg, crude yield 98%), which was used directly in the next step without further purification. The crude product was directly used in the next step without further purification.
References
[1] Patent: US2014/200215, 2014, A1. Location in patent: Paragraph 1002; 1006
4-IODO-1-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-IODO-1-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID manufacturers
- Product
- 4-Iodo-1-methylpyrazole-5-carboxylic Acid 75092-30-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- 4-IODO-1-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID 75092-30-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2019-05-24