Ethyl 4-iodo-1H-pyrazole-5-carboxylate
- Product Name
- Ethyl 4-iodo-1H-pyrazole-5-carboxylate
- CAS No.
- 179692-08-1
- Chemical Name
- Ethyl 4-iodo-1H-pyrazole-5-carboxylate
- Synonyms
- Ethyl 4-iodopyrazole-3-carboxylate;ethyl 4-iodo-1H-pyrazole-3-carboxylate;4-iodo-1H-pyrazole-3-ethyl carboxylate;Ethyl 4-iodo--1H-pyrazol-5-carboxylate;Ethyl 4-iodo-1H-pyrazole-5-carboxylate;4-iodo-1H-pyrazole-3-carboxylic acid ethyl ester;1H-Pyrazole-3-carboxylic acid, 4-iodo-, ethyl ester
- CBNumber
- CB02662046
- Molecular Formula
- C6H7IN2O2
- Formula Weight
- 266.04
- MOL File
- 179692-08-1.mol
Ethyl 4-iodo-1H-pyrazole-5-carboxylate Property
- Boiling point:
- 345.6±22.0 °C(Predicted)
- Density
- 1.935±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- pka
- 10.03±0.50(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- E920613
- Product name
- Ethyl4-Iodo-1H-pyrazole-5-carboxylate
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- P000723938
- Product name
- Ethyl 4-iodo-1H-pyrazole-5-carboxylate
- Purity
- 98%
- Packaging
- 250mg
- Price
- $13
- Updated
- 2021/12/16
- Product number
- P000723938
- Product name
- Ethyl 4-iodo-1H-pyrazole-5-carboxylate
- Purity
- 98%
- Packaging
- 1g
- Price
- $31
- Updated
- 2021/12/16
- Product number
- P000723938
- Product name
- Ethyl 4-iodo-1H-pyrazole-5-carboxylate
- Purity
- 98%
- Packaging
- 5g
- Price
- $92
- Updated
- 2021/12/16
- Product number
- 4H23-H-06
- Product name
- Ethyl 4-iodo-1H-pyrazole-3-carboxylate
- Packaging
- 1g
- Price
- $125
- Updated
- 2021/12/16
Ethyl 4-iodo-1H-pyrazole-5-carboxylate Chemical Properties,Usage,Production
Synthesis
5932-27-4
179692-08-1
To a solution of ethyl 1H-pyrazole-3-carboxylate (10.0 g, 71.4 mmol) in dichloromethane (DCM, 30 mL) was added N-iodosuccinimide (NIS, 22.5 g, 100 mmol) at room temperature. The reaction mixture was stirred at room temperature for 24 hours. Upon completion of the reaction, the reaction was quenched with distilled water (50 mL) and extracted with ethyl acetate (EtOAc, 60 mL x 3). The organic phases were combined, washed with saturated saline (50 mL × 3) and dried over anhydrous sodium sulfate (Na2SO4). After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography (eluent: petroleum ether/ethyl acetate, 1:5, v/v) to afford the target compound ethyl 4-iodo-1H-pyrazole-3-carboxylate (15.5 g, 82% yield). Mass spectrum (ESI+): m/z 267 [M+H]+.
References
[1] Patent: EP3235819, 2017, A1. Location in patent: Paragraph 0266; 0267
[2] Patent: KR101798840, 2017, B1. Location in patent: Paragraph 1335-1338
[3] Patent: WO2017/215600, 2017, A1. Location in patent: Page/Page column 53
[4] Patent: WO2012/6760, 2012, A1. Location in patent: Page/Page column 47
[5] Patent: WO2012/8999, 2012, A2. Location in patent: Page/Page column 47; 48
Ethyl 4-iodo-1H-pyrazole-5-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl 4-iodo-1H-pyrazole-5-carboxylate manufacturers
- Product
- Ethyl 4-iodo-1H-pyrazole-5-carboxylate 179692-08-1
- Price
- US $6.60/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg -1000kg
- Release date
- 2020-01-02