3-FLUORO-4-METHOXYPHENOL

Product Name: 3-FLUORO-4-METHOXYPHENOL
CAS No.: 452-11-9
Chemical Name: 3-FLUORO-4-METHOXYPHENOL
Synonyms: 3-FLUORO-4-METHOXYPHENOL;2-Fluoro-4-hydroxyanisole;Phenol, 3-fluoro-4-methoxy-;4-Aminomethyl-4-(3-bromo-phenyl)-piperidine-1-carboxylic acid tert-butyl ester
CBNumber: CB01509038
Molecular Formula: C7H7FO2
Formula Weight: 142.13
MOL File: 452-11-9.mol

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3-FLUORO-4-METHOXYPHENOL Property

Melting point:: 54-55 °C
Boiling point:: 248.2±20.0 °C(Predicted)
Density: 1.224±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 9.46±0.18(Predicted)
Appearance: Light yellow to brown Solid

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Safety

HS Code: 2909309090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: F593395
Product name: 3-Fluoro-4-methoxyphenol
Packaging: 5g
Price: $285
Updated: 2021/12/16

AK Scientific

Product number: X4271
Product name: 3-Fluoro-4-methoxyphenol
Packaging: 25g
Price: $401
Updated: 2021/12/16

Matrix Scientific

Product number: 119114
Product name: 3-Fluoro-4-methoxyphenol
Purity: 95+%
Packaging: 10g
Price: $522
Updated: 2021/12/16

Apolloscientific

Product number: PC6365
Product name: 3-Fluoro-4-methoxyphenol
Packaging: 1g
Price: $37
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2607-3-51
Product name: 3-Fluoro-4-methoxyphenol
Packaging: 1g
Price: $48
Updated: 2021/12/16

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3-FLUORO-4-METHOXYPHENOL Chemical Properties,Usage,Production

Uses

3-Fluoro-4-methoxyphenol is used in the preparation of non-peptidic NPBWR1 (GPR7) antagonists.

Synthesis

946833-20-1

452-11-9

Synthesis of 3-fluoro-4-methoxyphenol (14): 20 g of 3-fluoro-4-methoxyphenyl acetate (13, 0.11 mol) was dissolved in 200 ml of ethanol and 100 ml of 20% sodium hydroxide (NaOH) solution was added slowly. The reaction mixture was stirred at room temperature for 3 hours. Subsequently, the reaction solution was washed with water and acidified with 6N hydrochloric acid (HCl). The separated oil was extracted with ether and the extract was dried with anhydrous magnesium sulfate (MgSO4). After removal of the solvent under reduced pressure, a solid residue was obtained, which was purified by recrystallization from hexane, resulting in 13 g of the target product (83.3% yield).

References

[1] Patent: US2008/176920, 2008, A1. Location in patent: Page/Page column 15
[2] Patent: US2011/105527, 2011, A1. Location in patent: Page/Page column 18
[3] Patent: WO2014/210167, 2014, A1. Location in patent: Page/Page column 8

3-FLUORO-4-METHOXYPHENOL Preparation Products And Raw materials

Raw materials

Preparation Products

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3-FLUORO-4-METHOXYPHENOL Suppliers

China 98 India 3 United Kingdom 2 United States 8 Global 111

J & K SCIENTIFIC LTD.

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View Lastest Price from 3-FLUORO-4-METHOXYPHENOL manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 3-FLUORO-4-METHOXYPHENOL 452-11-9
Price: US $25.00-12.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200000KG
Release date: 2024-08-05

Shaanxi Dideu Medichem Co. Ltd

Product: 3-Fluoro-4-methoxyphenol 452-11-9
Price: US $1.00-1.60/KG
Min. Order: 1KG
Purity: 99%+
Supply Ability: 10000KG
Release date: 2024-04-24

Career Henan Chemical Co

Product: 3-FLUORO-4-METHOXYPHENOL 452-11-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500kg
Release date: 2019-12-25

452-11-9, 3-FLUORO-4-METHOXYPHENOLRelated Search:

1,4-DIMETHOXY-2-FLUOROBENZENE 2,3-DIFLUORO-4-METHOXYPHENOL 1,4-DIFLUORO-2,5-DIMETHOXYBENZENE 1,4-DIMETHOXYTETRAFLUOROBENZENE 4-BENZYLOXY-3-FLUORO-PHENOL 1,4-BIS(2,2,2-TRIFLUOROETHOXY)TETRAFLUOROBENZENE 1,4-BIS(TERT-BUTOXY)TETRAFLUOROBENZENE 1,4-BIS(ETHOXY)TETRAFLUOROBENZENE TETRAFLUORO-1,4-BIS(2,2,3,3-TETRAFLUOROPROPOXY)BENZENE AKOS BBS-00005190 AKOS BBS-00005175 AKOS BBS-00005159 SALOR-INT L142344-1EA AKOS BBS-00005191 AKOS BBS-00005158 1-[4-(BENZYLOXY)-3-FLUOROPHENOXY]-2-BROMO-4-NITROBENZENE AKOS BBS-00005180 AKOS BBS-00005189

3-FLUORO-4-METHOXYPHENOL

4-Aminomethyl-4-(3-bromo-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

2-Fluoro-4-hydroxyanisole

Phenol, 3-fluoro-4-methoxy-

452-11-9

Phenol&Thiophenol&Mercaptan