ChemicalBook > CAS DataBase List > 8-BROMO-2-(TRIFLUOROMETHYL)QUINOLIN-4-OL

8-BROMO-2-(TRIFLUOROMETHYL)QUINOLIN-4-OL

Product Name
8-BROMO-2-(TRIFLUOROMETHYL)QUINOLIN-4-OL
CAS No.
59108-43-9
Chemical Name
8-BROMO-2-(TRIFLUOROMETHYL)QUINOLIN-4-OL
Synonyms
BUTTPARK 91\04-55;8-BROMO-2-(TRIFLUOROMETHYL)QUINOLIN-4-OL;8-broMo-2-(trifluoroMethyl)-4-quinolinone;4-Quinolinol, 8-bromo-2-(trifluoromethyl)-;2-Trifluoromethyl-4-hydroxy-8-bromoquinoline;8-BroMo-4-hydroxy-2-(trifluoroMethyl)quinoline;-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER;8-bromo-2-(trifluoromethyl)quinolin-4-ol, 95%, HC-6749;8-BROMO-2-(TRIFLUOROMETHYL)QUINOLIN-4-OL ISO 9001：2015 REACH
CBNumber
CB0151243
Molecular Formula
C10H5BrF3NO
Formula Weight
292.05
MOL File
59108-43-9.mol
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8-BROMO-2-(TRIFLUOROMETHYL)QUINOLIN-4-OL Property

Melting point:
136 °C
Boiling point:
354.6±37.0 °C(Predicted)
Density 
1.771±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
pka
6.16±0.40(Predicted)
CAS DataBase Reference
59108-43-9
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Matrix Scientific
Product number
075504
Product name
8-Bromo-4-hydroxy-2-(trifluoromethyl)quinoline
Purity
95+%
Packaging
1g
Price
$231
Updated
2021/12/16
AK Scientific
Product number
W7202
Product name
8-Bromo-4-hydroxy-2-(trifluoromethyl)quinoline
Packaging
10g
Price
$304
Updated
2021/12/16
Matrix Scientific
Product number
075504
Product name
8-Bromo-4-hydroxy-2-(trifluoromethyl)quinoline
Purity
95+%
Packaging
5g
Price
$639
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0025421
Product name
8-BROMO-2-(TRIFLUOROMETHYL)QUINOLIN-4-OL
Purity
95.00%
Packaging
1G
Price
$831.6
Updated
2021/12/16
Matrix Scientific
Product number
075504
Product name
8-Bromo-4-hydroxy-2-(trifluoromethyl)quinoline
Purity
95+%
Packaging
10g
Price
$929
Updated
2021/12/16
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8-BROMO-2-(TRIFLUOROMETHYL)QUINOLIN-4-OL Chemical Properties,Usage,Production

Synthesis

372-31-6

615-36-1

587885-87-8

Step 1: Ethyl trifluoroacetoacetate (10 g, 58.5 mmol) was slowly added dropwise to a mixture of o-bromoaniline (10.7 g, 58.5 mmol) and polyphosphoric acid (PPA, 40 g) at 100 °C for a controlled time of less than 15 min. After the dropwise addition, the reaction mixture was warmed up to 150 °C with continuous stirring for 12 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was diluted with 10 wt% sodium hydroxide solution (160 mL). The precipitate was collected by filtration and the filtrate was acidified with concentrated hydrochloric acid. The precipitate was collected by filtration again and recrystallized with ethanol to give the target compound 140-3 (10.5 g, 62% yield) as a white solid. Mass spectrometry (ESI) analysis: C10H5BrF3NO [M + H]+ calculated value 292, measured value 292.

References

[1] European Journal of Organic Chemistry, 2003, # 8, p. 1576 - 1588
[2] Patent: EP3124482, 2017, A1. Location in patent: Paragraph 0281; 0282

8-BROMO-2-(TRIFLUOROMETHYL)QUINOLIN-4-OL Preparation Products And Raw materials

Raw materials

Preparation Products

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8-BROMO-2-(TRIFLUOROMETHYL)QUINOLIN-4-OL Suppliers

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View Lastest Price from 8-BROMO-2-(TRIFLUOROMETHYL)QUINOLIN-4-OL manufacturers

Honest Joy Holdings Limited
Product
8-Bromo-2-(Trifluoromethyl)Quinolin-4-OL 59108-43-9
Price
US $0.00/KG
Min. Order
1KG
Purity
97.9%
Supply Ability
100 tons
Release date
2022-01-14
Career Henan Chemical Co
Product
8-BROMO-2-(TRIFLUOROMETHYL)QUINOLIN-4-OL 59108-43-9
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
10 tons
Release date
2020-01-10

59108-43-9, 8-BROMO-2-(TRIFLUOROMETHYL)QUINOLIN-4-OLRelated Search:

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  • 8-BROMO-2-(TRIFLUOROMETHYL)QUINOLIN-4-OL ISO 9001：2015 REACH
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  • 59108-43-9