Ethyl 2-[5-(4-methylpiperazinyl)benzimidazol-2-yl]acetate

Product Name: Ethyl 2-[5-(4-methylpiperazinyl)benzimidazol-2-yl]acetate
CAS No.: 402948-37-2
Chemical Name: Ethyl 2-[5-(4-methylpiperazinyl)benzimidazol-2-yl]acetate
Synonyms: CHIR161527;Ethyl 2-[5-(4-methylpiperazinyl)benzimidazol-2-yl]acetate;Ethyl 2-[6-(4-Methyl-1-piperazinyl)-2-benzimidazolyl]acetate;ETHYL 2-[5-(4-METHYLPIPERAZINYL)BENZO[D]IMIDAZOL-2-YL]ACETATE;Ethyl [6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]acetate;ethyl 2-(5-(4-Methylpiperazin-1-yl)-1H-benzo[d]iMidazol-2-yl)acetate;ethyl 2-(6-(4-Methylpiperazin-1-yl)-1H-benzo[d]iMidazol-2-yl)acetate;1H-Benzimidazole-2-acetic acid, 6-(4-methyl-1-piperazinyl)-, ethyl ester;6-(4-methyl-piperazin-1-yl)-1H-benzoimidazol-2-yl]-acetic acid ethyl ester
CBNumber: CB01512663
Molecular Formula: C16H22N4O2
Formula Weight: 302.37
MOL File: 402948-37-2.mol

More

Less

Ethyl 2-[5-(4-methylpiperazinyl)benzimidazol-2-yl]acetate Property

Boiling point:: 516.4±50.0 °C(Predicted)
Density: 1.220±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 12.47±0.10(Predicted)
Appearance: White to yellow Solid

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H411Toxic to aquatic life with long lasting effects

More

Less

N-Bromosuccinimide Price

AK Scientific

Product number: 4808BB
Product name: Ethyl2-(5-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)acetate
Packaging: 100mg
Price: $128
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0377371
Product name: ETHYL-2-(6-(4-METHYLPIPERAZIN-1-YL)-1H-BENZO[D]IMIDAZOL-2-YL)ACETATE
Purity: 95.00%
Packaging: 5MG
Price: $505.89
Updated: 2021/12/16

Chemenu

Product number: CM252777
Product name: Ethyl2-(5-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)acetate
Purity: 97%
Packaging: 1g
Price: $636
Updated: 2021/12/16

Alichem

Product number: 402948372
Product name: Ethyl2-(5-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)acetate
Packaging: 1g
Price: $680
Updated: 2021/12/16

Ambeed

Product number: A108739
Product name: Ethyl2-(5-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)acetate
Purity: 97%
Packaging: 5g
Price: $914
Updated: 2021/12/16

More

Less

Ethyl 2-[5-(4-methylpiperazinyl)benzimidazol-2-yl]acetate Chemical Properties,Usage,Production

Synthesis

27317-59-5

23491-48-7

402948-37-2

General procedure for the synthesis of ethyl 2-[5-(4-methylpiperazinyl)benzimidazol-2-yl]acetate from ethyl 3-ethoxy-3-iminopropionate and 5-(4-methylpiperazinyl)-2-nitroaniline: 43 mmol of 5-(4-methylpiperazin-1-yl)-2-nitroaniline (compound b) was dissolved in 150 mL of anhydrous ethanol, and then loaded after sufficient dissolution into the first raw material storage tank 1; in the second raw material storage tank 2, 20 mL of 3.6% by weight HCl was dissolved in 150 mL of anhydrous ethanol; 65 mmol of β-ethoxy-β-imino-propionic acid ethyl ester hydrochloride (Compound c) was dissolved in 150 mL of ethanol, and was loaded into the third raw material storage tank 3 after being fully dissolved. At this time, the molar ratio of 5-(4-methylpiperazin-1-yl)-2-nitroaniline to β-ethoxy-β-imino-propionic acid ethyl ester hydrochloride was 1:1.5. The solutions in the first raw material storage tank 1 and the second raw material storage tank 2 were simultaneously pumped into the reaction device, and passed through the first microstructured mixer 4 into the first microstructured reactor (Reactor 1) having an inner diameter of 0.5 mm and a volume of 50 mL Perform the reaction. The microreactor parameters were set: a continuous flow rate of 1.4 mL/min in the first step, a reaction temperature of 80°C, and a residence time of 8 min, and the reaction mainly produced the intermediate 4-(4-methylpiperazin-1-yl)isophthalamide. Subsequently, the solution in the third raw material storage tank 3 and the reaction solution obtained in the reactor 1 were simultaneously pumped into the second microstructure mixer 5, and entered into the second microstructure reactor (reactor 2) with an inner diameter of 0.5 mm and a volume of 50 ml to carry out the mixing reaction. The microreactor parameters were set: continuous flow rate of 3 mL/min for the second step, reaction temperature of 80°C, and residence time of 20 min. After completion of the reaction, the reaction solution was concentrated to obtain an oily substance, which was solubilized with 15 mL of water, extracted several times with CH2Cl2, the organic phases were combined, and the solvent was evaporated to obtain the orange-colored oily substance, i.e., compound d, with a yield of 91%.

References

[1] Patent: CN108610293, 2018, A. Location in patent: Paragraph 0032; 0039-0044; 0048; 0050; 0052; 0054; 0056

Ethyl 2-[5-(4-methylpiperazinyl)benzimidazol-2-yl]acetate Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Ethyl 2-[5-(4-methylpiperazinyl)benzimidazol-2-yl]acetate Suppliers

China 39 India 1 United States 4 Global 44

Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.

Tel: 21-57721279
Fax: QQ：14057904
Email: sales@shydchem.com.cn
Country: China
ProdList: 998
Advantage: 56

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4720
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Taizhou Yikang Chemical Co., Ltd.

Tel: 0576-88501337 18906763631
Fax: +86-576-88501337
Email: sales@yikangchemicals.com
Country: China
ProdList: 270
Advantage: 58

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

ShangHai Angti Biotechnology Co., Ltd.

Tel: 13764913901
Fax: -
Email: info@angtibio.com
Country: China
ProdList: 4985
Advantage: 55

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 8011
Advantage: 55

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Biokitchen

Tel: 021-021-021-31663258 13795219287
Fax: 021-31663258
Email: donghuanwen@126.com
Country: China
ProdList: 8816
Advantage: 58

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: (5)02557626880
Email: dt3@aikonchem.com
Country: China
ProdList: 15493
Advantage: 58

More

Less

View Lastest Price from Ethyl 2-[5-(4-methylpiperazinyl)benzimidazol-2-yl]acetate manufacturers

Nanjing Fred Technology Co., Ltd

Product: Ethyl2-(5-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)acetate 402948-37-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2023-12-28

402948-37-2, Ethyl 2-[5-(4-methylpiperazinyl)benzimidazol-2-yl]acetateRelated Search:

(1H-BENZOIMIDAZOL-2-YL)-ACETIC ACID ETHYL ESTER 1H-Benzimidazole-2-aceticacid,methylester(9CI) Ethyl 2-[5-(4-methylpiperazinyl)benzimidazol-2-yl]acetate [5-(4-METHYL-PIPERAZIN-1-YL)-1H-BENZOIMIDAZOL-2-YL]-ACETIC ACID ETHYL ESTER 1H-Benzimidazole,2-(2-ethoxyethyl)-(9CI)

ethyl 2-(6-(4-Methylpiperazin-1-yl)-1H-benzo[d]iMidazol-2-yl)acetate

ethyl 2-(5-(4-Methylpiperazin-1-yl)-1H-benzo[d]iMidazol-2-yl)acetate

CHIR161527

ETHYL 2-[5-(4-METHYLPIPERAZINYL)BENZO[D]IMIDAZOL-2-YL]ACETATE

Ethyl 2-[5-(4-methylpiperazinyl)benzimidazol-2-yl]acetate

Ethyl [6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]acetate

6-(4-methyl-piperazin-1-yl)-1H-benzoimidazol-2-yl]-acetic acid ethyl ester

1H-Benzimidazole-2-acetic acid, 6-(4-methyl-1-piperazinyl)-, ethyl ester

Ethyl 2-[6-(4-Methyl-1-piperazinyl)-2-benzimidazolyl]acetate

402948-37-2

API intermediates