Ethyl 2-[5-(4-methylpiperazinyl)benzimidazol-2-yl]acetate
- Product Name
- Ethyl 2-[5-(4-methylpiperazinyl)benzimidazol-2-yl]acetate
- CAS No.
- 402948-37-2
- Chemical Name
- Ethyl 2-[5-(4-methylpiperazinyl)benzimidazol-2-yl]acetate
- Synonyms
- CHIR161527;Ethyl 2-[5-(4-methylpiperazinyl)benzimidazol-2-yl]acetate;Ethyl 2-[6-(4-Methyl-1-piperazinyl)-2-benzimidazolyl]acetate;ETHYL 2-[5-(4-METHYLPIPERAZINYL)BENZO[D]IMIDAZOL-2-YL]ACETATE;Ethyl [6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]acetate;ethyl 2-(5-(4-Methylpiperazin-1-yl)-1H-benzo[d]iMidazol-2-yl)acetate;ethyl 2-(6-(4-Methylpiperazin-1-yl)-1H-benzo[d]iMidazol-2-yl)acetate;1H-Benzimidazole-2-acetic acid, 6-(4-methyl-1-piperazinyl)-, ethyl ester;6-(4-methyl-piperazin-1-yl)-1H-benzoimidazol-2-yl]-acetic acid ethyl ester
- CBNumber
- CB01512663
- Molecular Formula
- C16H22N4O2
- Formula Weight
- 302.37
- MOL File
- 402948-37-2.mol
Ethyl 2-[5-(4-methylpiperazinyl)benzimidazol-2-yl]acetate Property
- Boiling point:
- 516.4±50.0 °C(Predicted)
- Density
- 1.220±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 12.47±0.10(Predicted)
- Appearance
- White to yellow Solid
N-Bromosuccinimide Price
- Product number
- 4808BB
- Product name
- Ethyl2-(5-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)acetate
- Packaging
- 100mg
- Price
- $128
- Updated
- 2021/12/16
- Product number
- CHM0377371
- Product name
- ETHYL-2-(6-(4-METHYLPIPERAZIN-1-YL)-1H-BENZO[D]IMIDAZOL-2-YL)ACETATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.89
- Updated
- 2021/12/16
- Product number
- A108739
- Product name
- Ethyl2-(5-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)acetate
- Purity
- 97%
- Packaging
- 100mg
- Price
- $51
- Updated
- 2021/12/16
- Product number
- A108739
- Product name
- Ethyl2-(5-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)acetate
- Purity
- 97%
- Packaging
- 250mg
- Price
- $105
- Updated
- 2021/12/16
- Product number
- CD11128682
- Product name
- Ethyl2-(5-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)acetate
- Purity
- 97%
- Packaging
- 1g
- Price
- $258
- Updated
- 2021/12/16
Ethyl 2-[5-(4-methylpiperazinyl)benzimidazol-2-yl]acetate Chemical Properties,Usage,Production
Synthesis
27317-59-5
23491-48-7
402948-37-2
General procedure for the synthesis of ethyl 2-[5-(4-methylpiperazinyl)benzimidazol-2-yl]acetate from ethyl 3-ethoxy-3-iminopropionate and 5-(4-methylpiperazinyl)-2-nitroaniline: 43 mmol of 5-(4-methylpiperazin-1-yl)-2-nitroaniline (compound b) was dissolved in 150 mL of anhydrous ethanol, and then loaded after sufficient dissolution into the first raw material storage tank 1; in the second raw material storage tank 2, 20 mL of 3.6% by weight HCl was dissolved in 150 mL of anhydrous ethanol; 65 mmol of β-ethoxy-β-imino-propionic acid ethyl ester hydrochloride (Compound c) was dissolved in 150 mL of ethanol, and was loaded into the third raw material storage tank 3 after being fully dissolved. At this time, the molar ratio of 5-(4-methylpiperazin-1-yl)-2-nitroaniline to β-ethoxy-β-imino-propionic acid ethyl ester hydrochloride was 1:1.5. The solutions in the first raw material storage tank 1 and the second raw material storage tank 2 were simultaneously pumped into the reaction device, and passed through the first microstructured mixer 4 into the first microstructured reactor (Reactor 1) having an inner diameter of 0.5 mm and a volume of 50 mL Perform the reaction. The microreactor parameters were set: a continuous flow rate of 1.4 mL/min in the first step, a reaction temperature of 80°C, and a residence time of 8 min, and the reaction mainly produced the intermediate 4-(4-methylpiperazin-1-yl)isophthalamide. Subsequently, the solution in the third raw material storage tank 3 and the reaction solution obtained in the reactor 1 were simultaneously pumped into the second microstructure mixer 5, and entered into the second microstructure reactor (reactor 2) with an inner diameter of 0.5 mm and a volume of 50 ml to carry out the mixing reaction. The microreactor parameters were set: continuous flow rate of 3 mL/min for the second step, reaction temperature of 80°C, and residence time of 20 min. After completion of the reaction, the reaction solution was concentrated to obtain an oily substance, which was solubilized with 15 mL of water, extracted several times with CH2Cl2, the organic phases were combined, and the solvent was evaporated to obtain the orange-colored oily substance, i.e., compound d, with a yield of 91%.
References
[1] Patent: CN108610293, 2018, A. Location in patent: Paragraph 0032; 0039-0044; 0048; 0050; 0052; 0054; 0056
Ethyl 2-[5-(4-methylpiperazinyl)benzimidazol-2-yl]acetate Preparation Products And Raw materials
Raw materials
Preparation Products
Ethyl 2-[5-(4-methylpiperazinyl)benzimidazol-2-yl]acetate Suppliers
- Tel
- 21-57721279
- Fax
- QQ：14057904
- sales@shydchem.com.cn
- Country
- China
- ProdList
- 998
- Advantage
- 56
- Tel
- 020-39119399 18927568969
- Fax
- 020-39119999
- isunpharm@qq.com
- Country
- China
- ProdList
- 4720
- Advantage
- 55
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 0576-88501337 18906763631
- Fax
- +86-576-88501337
- sales@yikangchemicals.com
- Country
- China
- ProdList
- 270
- Advantage
- 58
- Tel
- 13764913901
- Fax
- -
- info@angtibio.com
- Country
- China
- ProdList
- 4981
- Advantage
- 55
- Tel
- 15076683720
- Fax
- 022-23754520
- klq@cw-bio.com
- Country
- China
- ProdList
- 8011
- Advantage
- 55
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 021-021-021-31663258 13795219287
- Fax
- 021-31663258
- donghuanwen@126.com
- Country
- China
- ProdList
- 8816
- Advantage
- 58
- Tel
- 025-58859352 18068836627
- Fax
- (5)02557626880
- dt3@aikonchem.com
- Country
- China
- ProdList
- 15493
- Advantage
- 58
- Tel
- 021-61469567 13482353728
- Fax
- 021-61161605
- sales@fdc-chemical.com
- Country
- China
- ProdList
- 9721
- Advantage
- 58
- Tel
- 15088289376
- 248775804@qq.com
- Country
- China
- ProdList
- 4995
- Advantage
- 58
- Tel
- 4009004166/18616739031 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52687
- Advantage
- 58
- Tel
- 0512-65816829 18662214788
- Fax
- 0512-65816829
- info@rovathin.com.cn
- Country
- China
- ProdList
- 9987
- Advantage
- 58
- Tel
- 021-58461859 15821823057
- service@aiviche.com
- Country
- China
- ProdList
- 49312
- Advantage
- 58
- Tel
- nanfengdrug@163.com; 18616377689
- nanfengdrug@163.com
- Country
- China
- ProdList
- 20009
- Advantage
- 58
- Tel
- 650-6922368
- sales@achemblock.com
- Country
- China
- ProdList
- 2992
- Advantage
- 58
- Tel
- 0371-0371-55135753 18003832934
- Fax
- QQ：2853979818
- 2853979818@qq.com
- Country
- China
- ProdList
- 9991
- Advantage
- 58
- Tel
- 15216675652
- xuanyuelj@163.com
- Country
- China
- ProdList
- 2864
- Advantage
- 58
- Tel
- 1701086315
- Fax
- 1701086315@qq.com
- dexuanpharma@126.com
- Country
- China
- ProdList
- 9475
- Advantage
- 58
- Tel
- 13180081292 13180081292
- contact@wetogethermed.com
- Country
- China
- ProdList
- 7942
- Advantage
- 58
- Tel
- 400-8210725 4008210725
- malulu@leyan.com
- Country
- China
- ProdList
- 40000
- Advantage
- 58
- Tel
- 4000255188
- Fax
- 025 86918232
- sales_china@pharmablock.com
- Country
- China
- ProdList
- 10000
- Advantage
- 58
- Tel
- 027-59101668 19945030958
- Fax
- 027-59101668
- 2881924765@qq.com
- Country
- China
- ProdList
- 7936
- Advantage
- 58
- Tel
- 400-6005915
- sales@picasso-e.com
- Country
- China
- ProdList
- 39653
- Advantage
- 58
- Tel
- +86(21)5895 0110 19945755304
- sales@chemany.com
- Country
- China
- ProdList
- 9984
- Advantage
- 58
- Tel
- 18171815831
- 1341138380@qq.com
- Country
- China
- ProdList
- 4309
- Advantage
- 58
- Tel
- 1173954148q
- meishipharma@126.com
- Country
- China
- ProdList
- 20033
- Advantage
- 58
- Tel
- 010-50973130 17801761073
- Gsiyu@solarbio.com
- Country
- China
- ProdList
- 50464
- Advantage
- 58
- Tel
- 021-57520305 13795461237
- zhuruyan@jskchem.com
- Country
- China
- ProdList
- 49234
- Advantage
- 58
- Tel
- 4000255188
- sales@pharmablock.com
- Country
- China
- ProdList
- 7268
- Advantage
- 58
- Tel
- 15192473210
- 302633902@qq.com
- Country
- China
- ProdList
- 4480
- Advantage
- 58
- Tel
- 029-81136151 17392212881
- 1095@dideu.com
- Country
- China
- ProdList
- 9984
- Advantage
- 58
- Tel
- 13290191024
- 3887351301@qq.com
- Country
- China
- ProdList
- 1910
- Advantage
- 58
- Tel
- 021-68689288 15300790979
- Fax
- wechat 18721550091
- info@mkbio.com.cn
- Country
- China
- ProdList
- 5000
- Advantage
- 58
- Tel
- +86-512-68323658 +86-18168183658
- sales1@artkmedchem.com
- Country
- China
- ProdList
- 39002
- Advantage
- 58
- Tel
- +86-25-84696168 +86-15380713688
- Austin@fredbio.com
- Country
- China
- ProdList
- 2428
- Advantage
- 58
- Tel
- +86-571-87711850
- market18@leapchem.com
- Country
- China
- ProdList
- 43339
- Advantage
- 58
- Tel
- +86-86-22-87899925 +86-8618522618860
- Fax
- 86-22-87899925
- 18522618860@163.com
- Country
- China
- ProdList
- 694
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@rovathin.com
- Country
- China
- ProdList
- 4395
- Advantage
- 58
View Lastest Price from Ethyl 2-[5-(4-methylpiperazinyl)benzimidazol-2-yl]acetate manufacturers
- Product
- Ethyl2-(5-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)acetate 402948-37-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1 ton
- Release date
- 2023-12-28