Disitertide

ChemicalBook > CAS DataBase List > Disitertide

Product Name: Disitertide
CAS No.: 272105-42-7
Chemical Name: Disitertide
Synonyms: disitertide;P144 Peptide;TSLDASIIWAMMQN;P144;P144 PEPTIDE;DISITERTIDE, >98%;Disitertide,P144,P144 Peptide, >98%;DisitertideH-Gly-Arg-Gly-Asp-Asn-Pro-OH;L-Asparagine,L-threonyl-L-seryl-L-leucyl-L-a-aspartyl-L-alanyl-L-seryl-L-isoleucyl-L-isoleucyl-L-tryptophyl-L-alanyl-L-methionyl-L-methionyl-L-glutaminyl-;L-Asparagine, L-threonyl-L-seryl-L-leucyl-L-α-aspartyl-L-alanyl-L-seryl-L-isoleucyl-L-isoleucyl-L-tryptophyl-L-alanyl-L-methionyl-L-methionyl-L-glutaminyl-;L-Threonyl-L-seryl-L-leucyl-L-alpha-aspartyl-L-alanyl-L-seryl-L-isoleucyl-L-isoleucyl-L-tryptophyl-L-alanyl-L-methionyl-L-methionyl-L-glutaminyl-L-asparagine
CBNumber: CB01518504
Molecular Formula: C68H109N17O22S2
Formula Weight: 1580.84
MOL File: 272105-42-7.mol

Less

Disitertide Property

Boiling point:: 1968.7±65.0 °C(Predicted)
Density: 1.327
storage temp.: Store at -20°C
solubility: DMSO : ≥ 200 mg/mL (126.52 mM);Water : < 0.1 mg/mL (insoluble)
pka: 3.15±0.10(Predicted)
InChIKey: IUYPEUHIWDMJLM-INGCBPSVNA-N

Less

Hazard and Precautionary Statements (GHS)

Less

N-Bromosuccinimide Price

ChemScene

Product number: CS-5989
Product name: Disitertide
Packaging: 1mg
Price: $132
Updated: 2021/12/16

ChemScene

Product number: CS-5989
Product name: Disitertide
Packaging: 5mg
Price: $528
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611411
Product name: Disitertide
Packaging: 5mg
Price: $544
Updated: 2021/12/16

ChemScene

Product number: CS-5989
Product name: Disitertide
Packaging: 10mg
Price: $900
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611411
Product name: Disitertide
Packaging: 10mg
Price: $912.9
Updated: 2021/12/16

Less

Disitertide Chemical Properties,Usage,Production

Description

Disitertide is an inhibitor of TGF-β1. It prevents TGF-β1-dependent inhibition of MV1Lu proliferation in vitro and markedly reduces binding of TGF-β1 to its receptors. Disitertide blocks TGF-β1-dependent stimulation of a reporter gene under the control of human α2(I) collagen promoter. Treatment with Disitertide at low doses causes a significant inhibition of HSC activation and a marked reduction in liver fibrosis in a rat model of chronic exposure to CCl4. A dose as low as 70 μg of the 15-mer peptide Disitertide, given to rats (300 g body weight) on alternate days, decreases fibrogenesis significantly during chronic exposure to CCl4.

Biological Activity

Disitertide (P144) TFA is a polypeptide inhibitor of transforming growth factor TGFβ1, specifically blocking its interaction with the receptor. Disitertide (P144) is also an inhibitor of PI3K and an inducer of apoptosis.

in vitro

Disitertide (100 μg/mL) suppresses the protein expression levels of PI3K and p-Akt, and induce the protein expression of Bax in MC3T3-E1 cells.
Disitertide (TGF-β1 inhibitor) abrogates the MACC1- AS1 expression in GC cells, suggesting that targeting TGFβ signaling pathway may be a potential strategy to inhibit MSC-induced stemness and chemoresistance.
Disitertide (P144, 10 μg/mL to 200 μg/mL) affects proliferation,

Western Blot Analysis

Cell Line:	Mouse embryo osteoblast precursor MC3T3-E1 cells.
Concentration:
Concentration:	100 μg/mL.
Incubation Time:	4 h.
Result:	Significantly suppressed the protein expression levels of PI3K and p-Akt, and induced the protein expression of Bax in MC3T3-E1 cells compared with the miR-590 group.

in vivo

Disitertide (Topical application, 300 μg/mL) may promote scar maturation and clinical improvement of hypertrophic scar morphology features in an “in vivo” model in nude mice after two weeks of treatment.

Animal Model:	Human hypertrophic scars were implanted in 60 nude mice.
Dosage:	300 μg/mL was added the Lipogel.
Administration:	Topical application daily administered.
Result:	Successful shedding was achieved in 83,3% of the xenografts.

storage

Store at -20°C

Disitertide Preparation Products And Raw materials

Raw materials

Preparation Products

Less

Disitertide Suppliers

China 41 United States 7 Global 48

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15185
Advantage: 58

ShangHai Biochempartner Co.,Ltd

Tel: 17754423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 29796
Advantage: 68

Nanjing Leon Biological Technology Co., Ltd.

Tel: 17705183659
Fax: 84523390
Email: sales@njleonbiotech.com
Country: China
ProdList: 5503
Advantage: 55

Hangzhou Peptidego Biotech Co.,Ltd.

Tel: 0571-87213919
Fax: 0571-87213919
Email: eric@peptidego.com
Country: China
ProdList: 6527
Advantage: 58

Zhejiang J&C Biological Technology Co.,Limited

Tel: +1-2135480471 +1-2135480471
Email: sales@sarms4muscle.com
Country: China
ProdList: 10523
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 15093356674;
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30255
Advantage: 58

DC Chemicals

Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Country: China
ProdList: 9412
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49391
Advantage: 58

Shanghai Zeye Biotechnology Co., Ltd.

Tel: 021-61998551 13122364865
Email: sale1@shzysw.net
Country: China
ProdList: 9771
Advantage: 58

Absin Bioscience Inc.

Tel: 021-38015121 15000105423
Email: chenjw@absin.cn
Country: China
ProdList: 24734
Advantage: 58

Shanghai hongqu biomedical technology co. LTD

Tel: 88888888888
Email: hongquchem@qq.com
Country: China
ProdList: 5132
Advantage: 58

Wuxi Helen Biotechnology Co., Ltd.,

Tel: 0510-85629785 18013409632
Fax: 0510-85625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 14092
Advantage: 58

Ontores Biotech

Tel: 0571-88760729 18072970094
Email: supports@ontorespeptide.com
Country: China
ProdList: 2696
Advantage: 58

Hangzhou Go Top Peptide Biotech

Tel: 0571-88211921 13355716090
Email: Sales@gotopbio.com
Country: China
ProdList: 2835
Advantage: 58

DONBOO AMINO ACID COMPANY

Tel: +8613063595538
Email: donboo@donboo.com
Country: China
ProdList: 9365
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 29778
Advantage: 58

InvivoChem

Tel: 13549236410
Email: sales@invivochem.cn
Country: China
ProdList: 6749
Advantage: 58

Nanjing Yuanpeptide Biotech Co.，Ltd.

Tel: 18168071971
Email: support@yuan-peptide.com
Country: China
ProdList: 2977
Advantage: 58

Shaoxing Junyu Biotechnology Co., LTD

Tel: 0571-88211921 15572296305
Email: sales4@gotopbio.com
Country: China
ProdList: 5144
Advantage: 58

Hangzhou Sinoda Pharmaceutical Technology Co. LTD

Tel: 0571-87213919 17306812703
Email: 3007955328@qq.com
Country: China
ProdList: 6130
Advantage: 58

Hangzhou Baige Pharmaceutical Technology Co. , Ltd.

Tel: 0571-85350119 15888826472
Email: 15888826472@163.com
Country: China
ProdList: 2729
Advantage: 58

Shanghai HongTide Biotechnology Co.,Ltd.

Tel: 19961912513
Email: sales@hongtide.com
Country: China
ProdList: 4580
Advantage: 58

Zhongke Huayao (Jiangsu) Biotechnology Co., Ltd

Tel: 18014456767 18014456767
Email: wenxi@jszkhy.com
Country: China
ProdList: 1349
Advantage: 58

Combio (Suzhou) Ltd.

Tel: 0512-51886999 17706251929
Email: office@combiosz.com
Country: China
ProdList: 2224
Advantage: 58

https://hanhongsci.com/

Tel: 021-54306202 18917919676
Email: info@hanhongsci.com
Country: China
ProdList: 29990
Advantage: 58

Zhejiang Jiekun Biotechnology Co., Ltd

Tel: 0571-88211951 13735575465
Email: sales1@gotopbio.com
Country: China
ProdList: 4904
Advantage: 58

Taiyuan Bailihengkang Biotechnology Co., Ltd

Tel: 19135651983 19135651983
Email: 18611134419@163.com
Country: China
ProdList: 4977
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12007
Advantage: 58

Hangzhou Beiputai Biopharmaceutical Co., Ltd

Tel: 0571-85350119 13305819357
Email: bptsales@163.com
Country: China
ProdList: 3793
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9180
Advantage: 58

TargetMol Chemicals Inc.

Tel: 15002134094
Email: marketing@targetmol.com
Country: China
ProdList: 24246
Advantage: 58

Shenzhen Nexconn Pharmatechs Ltd

Tel: +86-755-89396905 +86-15013857715
Email: admin@nexconn.com
Country: China
ProdList: 10247
Advantage: 58

Shanghai Acmec Biochemical Technology Co., Ltd.

Tel: +undefined18621343501
Email: product@acmec-e.com
Country: China
ProdList: 33350
Advantage: 58

Zhejiang Hangyu API Co., Ltd

Tel: +8617531972939
Email: anna@api-made.com
Country: China
ProdList: 2944
Advantage: 58

GIHI CHEMICALS CO.,LIMITED

Tel: +8618058761490
Email: info@gihichemicals.com
Country: China
ProdList: 50000
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6846
Advantage: 58

Shanghai Machine Pure Industrial Co., Ltd.

Tel: --
Fax: --
Email: 3245176082@qq.com
Country: CHINA
ProdList: 6800
Advantage: 58

Shanghai Wowu Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: shhebio@126.com
Country: CHINA
ProdList: 6137
Advantage: 58

272105-42-7, DisitertideRelated Search:

L-Alanyl-L-Glutamine Diethylstilbestrol EC 2.3.2.2 L-Asparagine FMOC-ASN(TRT)-OPFP L-Glutamine Disitertide

disitertide

L-Threonyl-L-seryl-L-leucyl-L-alpha-aspartyl-L-alanyl-L-seryl-L-isoleucyl-L-isoleucyl-L-tryptophyl-L-alanyl-L-methionyl-L-methionyl-L-glutaminyl-L-asparagine

P144 Peptide

P144;P144 PEPTIDE

TSLDASIIWAMMQN

DISITERTIDE, >98%

Disitertide,P144,P144 Peptide, >98%

L-Asparagine, L-threonyl-L-seryl-L-leucyl-L-α-aspartyl-L-alanyl-L-seryl-L-isoleucyl-L-isoleucyl-L-tryptophyl-L-alanyl-L-methionyl-L-methionyl-L-glutaminyl-

DisitertideH-Gly-Arg-Gly-Asp-Asn-Pro-OH

L-Asparagine,L-threonyl-L-seryl-L-leucyl-L-a-aspartyl-L-alanyl-L-seryl-L-isoleucyl-L-isoleucyl-L-tryptophyl-L-alanyl-L-methionyl-L-methionyl-L-glutaminyl-

272105-42-7

C68H109N17O22S2