ChemicalBook > CAS DataBase List > Disitertide

Disitertide

Product Name
Disitertide
CAS No.
272105-42-7
Chemical Name
Disitertide
Synonyms
disitertide;P144 Peptide;TSLDASIIWAMMQN;P144;P144 PEPTIDE;DISITERTIDE, >98%;Disitertide,P144,P144 Peptide, >98%;DisitertideH-Gly-Arg-Gly-Asp-Asn-Pro-OH;L-Asparagine,L-threonyl-L-seryl-L-leucyl-L-a-aspartyl-L-alanyl-L-seryl-L-isoleucyl-L-isoleucyl-L-tryptophyl-L-alanyl-L-methionyl-L-methionyl-L-glutaminyl-;L-Asparagine, L-threonyl-L-seryl-L-leucyl-L-α-aspartyl-L-alanyl-L-seryl-L-isoleucyl-L-isoleucyl-L-tryptophyl-L-alanyl-L-methionyl-L-methionyl-L-glutaminyl-;L-Threonyl-L-seryl-L-leucyl-L-alpha-aspartyl-L-alanyl-L-seryl-L-isoleucyl-L-isoleucyl-L-tryptophyl-L-alanyl-L-methionyl-L-methionyl-L-glutaminyl-L-asparagine
CBNumber
CB01518504
Molecular Formula
C68H109N17O22S2
Formula Weight
1580.84
MOL File
272105-42-7.mol
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Disitertide Property

Boiling point:
1968.7±65.0 °C(Predicted)
Density 
1.327
storage temp. 
Store at -20°C
solubility 
DMSO : ≥ 200 mg/mL (126.52 mM);Water : < 0.1 mg/mL (insoluble)
pka
3.15±0.10(Predicted)
InChIKey
IUYPEUHIWDMJLM-INGCBPSVNA-N
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-5989
Product name
Disitertide
Packaging
1mg
Price
$132
Updated
2021/12/16
ChemScene
Product number
CS-5989
Product name
Disitertide
Packaging
5mg
Price
$528
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611411
Product name
Disitertide
Packaging
5mg
Price
$544
Updated
2021/12/16
ChemScene
Product number
CS-5989
Product name
Disitertide
Packaging
10mg
Price
$900
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611411
Product name
Disitertide
Packaging
10mg
Price
$912.9
Updated
2021/12/16
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Disitertide Chemical Properties,Usage,Production

Description

Disitertide is an inhibitor of TGF-β1. It prevents TGF-β1-dependent inhibition of MV1Lu proliferation in vitro and markedly reduces binding of TGF-β1 to its receptors. Disitertide blocks TGF-β1-dependent stimulation of a reporter gene under the control of human α2(I) collagen promoter. Treatment with Disitertide at low doses causes a significant inhibition of HSC activation and a marked reduction in liver fibrosis in a rat model of chronic exposure to CCl4. A dose as low as 70 μg of the 15-mer peptide Disitertide, given to rats (300 g body weight) on alternate days, decreases fibrogenesis significantly during chronic exposure to CCl4.

Biological Activity

Disitertide (P144) TFA is a polypeptide inhibitor of transforming growth factor TGFβ1, specifically blocking its interaction with the receptor. Disitertide (P144) is also an inhibitor of PI3K and an inducer of apoptosis.

in vitro

Disitertide (100 μg/mL) suppresses the protein expression levels of PI3K and p-Akt, and induce the protein expression of Bax in MC3T3-E1 cells.
Disitertide (TGF-β1 inhibitor) abrogates the MACC1- AS1 expression in GC cells, suggesting that targeting TGFβ signaling pathway may be a potential strategy to inhibit MSC-induced stemness and chemoresistance.
Disitertide (P144, 10 μg/mL to 200 μg/mL) affects proliferation,

Western Blot Analysis

Cell Line: Mouse embryo osteoblast precursor MC3T3-E1 cells.
Concentration:
Concentration: 100 μg/mL.
Incubation Time: 4 h.
Result: Significantly suppressed the protein expression levels of PI3K and p-Akt, and induced the protein expression of Bax in MC3T3-E1 cells compared with the miR-590 group.

in vivo

Disitertide (Topical application, 300 μg/mL) may promote scar maturation and clinical improvement of hypertrophic scar morphology features in an “in vivo” model in nude mice after two weeks of treatment.

Animal Model: Human hypertrophic scars were implanted in 60 nude mice.
Dosage: 300 μg/mL was added the Lipogel.
Administration: Topical application daily administered.
Result: Successful shedding was achieved in 83,3% of the xenografts.

storage

Store at -20°C

Disitertide Preparation Products And Raw materials

Raw materials

Preparation Products

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272105-42-7, DisitertideRelated Search:


  • disitertide
  • L-Threonyl-L-seryl-L-leucyl-L-alpha-aspartyl-L-alanyl-L-seryl-L-isoleucyl-L-isoleucyl-L-tryptophyl-L-alanyl-L-methionyl-L-methionyl-L-glutaminyl-L-asparagine
  • P144 Peptide
  • P144;P144 PEPTIDE
  • TSLDASIIWAMMQN
  • DISITERTIDE, >98%
  • Disitertide,P144,P144 Peptide, >98%
  • L-Asparagine, L-threonyl-L-seryl-L-leucyl-L-α-aspartyl-L-alanyl-L-seryl-L-isoleucyl-L-isoleucyl-L-tryptophyl-L-alanyl-L-methionyl-L-methionyl-L-glutaminyl-
  • DisitertideH-Gly-Arg-Gly-Asp-Asn-Pro-OH
  • L-Asparagine,L-threonyl-L-seryl-L-leucyl-L-a-aspartyl-L-alanyl-L-seryl-L-isoleucyl-L-isoleucyl-L-tryptophyl-L-alanyl-L-methionyl-L-methionyl-L-glutaminyl-
  • 272105-42-7
  • C68H109N17O22S2