Tosedostat

ChemicalBook > CAS DataBase List > Tosedostat

Product Name: Tosedostat
CAS No.: 238750-77-1
Chemical Name: Tosedostat
Synonyms: CS-2714;Chr-2797;BB-76163;Tosedosta;tosedostat;CHR 2797;CHR-2797;Tosedostat (CHR2797);CHR2797 (Tosedostat);(S)-cyclopentyl 2-((R)-2-((S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl)-4-methylpentanamido)-2-phenylacetate;cyclopentyl (S)-2-((R)-2-((S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl)-4-methylpentanamido)-2-phenylacetate
CBNumber: CB01518544
Molecular Formula: C21H30N2O6
Formula Weight: 406.47
MOL File: 238750-77-1.mol

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Tosedostat Property

Density: 1.24
storage temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility: ≥40.6 mg/mL in DMSO; insoluble in H2O; ≥15.07 mg/mL in EtOH with ultrasonic
form: A crystalline solid
pka: 9.44±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 23395
Product name: Tosedostat
Purity: ≥98%
Packaging: 1mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 23395
Product name: Tosedostat
Purity: ≥98%
Packaging: 5mg
Price: $356
Updated: 2024/03/01

Tocris

Product number: 3595
Product name: CHR2797
Purity: ≥98%(HPLC)
Packaging: 1
Price: $149
Updated: 2021/12/16

Tocris

Product number: 3595
Product name: CHR2797
Purity: ≥98%(HPLC)
Packaging: 10
Price: $314
Updated: 2021/12/16

TRC

Product number: T549000
Product name: Tosedostat
Packaging: 0.5mg
Price: $160
Updated: 2021/12/16

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Tosedostat Chemical Properties,Usage,Production

Description

Tosedostat is an inhibitor of aminopeptidases (IC₅₀s = 100, 150, and 220 nM for LAP, PUSA, and aminopeptidase N, respectively). It inhibits proliferation of human leukemia cell lines in vitro irrespective of p53, PTEN, or K-RAS mutational status (IC₅₀s = 10-770 nM). Tosedostat induces up-regulation of genes in amino acid transport and metabolic pathways and inhibits phosphorylation of mammalian target of rapamycin (mTOR) substrates in HL-60 cells, markers of amino acid depletion. In vivo, tosedostat (100 mg/kg) reduces total tumor burden and the number of spontaneous metastases in a mouse MDA-MB-435 xenograft model. Formulations containing tosedostat are under clinical investigation for the treatment of myeloid leukemia.

Uses

CHR-2797 is a novel metalloenzyme inhibitor that is converted into a pharmacological active acid product (CHR-79888) inside cells. CHR-2797 exerts antiproliferative effects against a range of tumor cell lines in vitro and in vivo and shows selectivity for transformed over nontransformed cells. Its antiproliferative effects are at least 300 times more potent than the prototypical aminopeptidase inhibitor, Bestatin.

Uses

Labelled Tosedostat nst a range of tumor cell lines in vitro and in vivo and shows selectivity for transformed over nontransformed cells. Its antiproliferative effects are at least 300 times more potent than the prototyp ical aminopeptidase inhibitor, Bestatin.

Definition

ChEBI: (2S)-2-[[(2R)-2-[(1S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]amino]-2-phenylacetic acid cyclopentyl ester is a secondary carboxamide, a hydroxamic acid and a carboxylic ester.

Biological Activity

Aminopeptidase inhibitor (IC 50 values are 100, 150, 220, > 1000, > 5000, > 10000 and > 30000 nM for LAP, PuSA, aminopeptidase N, aminopeptidase B, PILSAP, LTA 4 hydrolase and MetAP2 respectively). Potently inhibits tumor cell proliferation in a variety of tumor cell lines in vitro and in vivo .

storage

Store at -20°C

Tosedostat Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Tosedostat manufacturers

Shanghai Affida new material science and technology center

Product: Tosedostat 238750-77-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99
Supply Ability: 10 tons
Release date: 2024-04-24

Hebei Mingeng Biotechnology Co., Ltd

Product: Tosedostat 238750-77-1
Price: US $200.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg/Month
Release date: 2022-11-28

Career Henan Chemical Co

Product: Tosedostat 238750-77-1
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1ton
Release date: 2020-01-10

238750-77-1, TosedostatRelated Search:

CYCLOPENTYLMAGNESIUM CHLORIDE TETRAPENTYLAMMONIUM BROMIDE Methyl acrylate TERT-AMYL METHYL ETHER Methyl acetate Cyclopentanecarbaldehyde Bensulfuron methyl CHLOROPHOSPHONAZO III Thiophanate-methyl Methylparaben Kresoxim-methyl Methyl Parathion-methyl 2-Chlorophenyl cyclopentyl ketone Methyl bromide Tosedostat

tosedostat

alpha-[[(2R)-2-[(1S)-1-Hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]amino]benzeneacetic acid cyclopentyl ester

Tosedostat (CHR2797)

Benzeneacetic acid, alpha-(((2R)-2-((1S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl)-4-methyl-1-oxopentyl)amino)-, cyclopentyl ester, (alphas)-

Chr-2797

α-[[(2R)-2-[(1S)-1-Hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]amino]-benzeneaceticacidcyclopentlyester

CHR 2797;CHR-2797

CS-2714

CHR2797 (Tosedostat)

BB-76163

(S)-cyclopentyl 2-((R)-2-((S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl)-4-methylpentanamido)-2-phenylacetate

Benzeneacetic acid, α-[[(2R)-2-[(1S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]amino]-, cyclopentyl ester, (αS)-

Tosedosta

cyclopentyl (S)-2-((R)-2-((S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl)-4-methylpentanamido)-2-phenylacetate

238750-77-1

C21H25D5N2O6

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