ChemicalBook > CAS DataBase List > 2-(trans-4-Aminocyclohexyl)propan-2-ol

2-(trans-4-Aminocyclohexyl)propan-2-ol

Product Name
2-(trans-4-Aminocyclohexyl)propan-2-ol
CAS No.
899806-45-2
Chemical Name
2-(trans-4-Aminocyclohexyl)propan-2-ol
Synonyms
2-((1r,4r)-4-aMinocyclohexyl)propan-2-ol;SW-25;SWF-25;2-(trans-4-Aminocyclohexyl);2-(trans-4-AMino-cyclohex...;2-(4-aminocyclohexyl)-2-propanol;2-(4-aminocyclohexyl)propan-2-ol;2-(trans-4-AMino-cyclohexyl)-propan-2-ol;TRANS-2-(4-AMINOCYCLOHEXYL)-2-HYDROXYPROPANE;Cyclohexanemethanol,4-amino-a,a-dimethyl-, trans-
CBNumber
CB01519349
Molecular Formula
C9H19NO
Formula Weight
157.26
MOL File
899806-45-2.mol
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2-(trans-4-Aminocyclohexyl)propan-2-ol Property

Boiling point:
240.2±13.0 °C(Predicted)
Density 
0.975±0.06 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
pka
15.18±0.29(Predicted)
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Safety

RIDADR 
UN3259
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

SynQuest Laboratories
Product number
4H56-1-QQ
Product name
2-(trans-4-Aminocyclohexyl)propan-2-ol
Packaging
250mg
Price
$149
Updated
2021/12/16
AK Scientific
Product number
4947AC
Product name
2-(trans-4-Aminocyclohexyl)propan-2-ol
Packaging
1g
Price
$291
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-1-QQ
Product name
2-(trans-4-Aminocyclohexyl)propan-2-ol
Packaging
1g
Price
$395
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0158356
Product name
TRANS-2-(4-AMINOCYCLOHEXYL)-2-HYDROXYPROPANE
Purity
95.00%
Packaging
5MG
Price
$499.04
Updated
2021/12/16
Matrix Scientific
Product number
112751
Product name
2-(trans-4-Amino-cyclohexyl)-propan-2-ol
Packaging
1g
Price
$564
Updated
2021/12/16
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2-(trans-4-Aminocyclohexyl)propan-2-ol Chemical Properties,Usage,Production

Description

2-(trans-4-Aminocyclohexyl)propan-2-ol is a white solid organic heterocyclic compound and a pharmaceutical intermediate component for the synthesis of PIM Kinase Inhibitor TP-3654, which is an orally available second-generation PIM Kinase Inhibitor TP-3654 is an orally available second-generation selective ATP-competitive proviral integration site inhibitor for the treatment of Moloney murine leukaemia virus (PIM) kinase, with potential anti-tumour activity.

Uses

2-(trans-4-Aminocyclohexyl)propan-2-ol can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Synthesis


Step 1
To a solution of trans-benzyl 4-(dibenzylamino)cyclohexanecarboxylate (290 g X 5, 3.6 mol) in 2 L of THF under N2 at 0 °C, MeMgBr (800 mL) was added. The mixture was stirred at room temperature overnight and then quenched with 1.5 L of saturated NH4Cl. The resulting mixture was extracted wtih EtOAc. The product was extracted with 1 M HCl to the aqueous phase, which was then wash with EtOAc. The aqueous phase was then neutralized with NaOH, extracted with EtOAc, washed with brine, dried with Na2SO4 and concentrated in vacuo to give the 2-(trans-4-(dibenzylamino)cyclohexyl)propan-2-ol. White solid, yield 950 g, 78.3%.
Step 2
A mixture of 2-(trans-4-(dibenzylamino)cyclohexyl)propan-2-ol (120 g X 8,356mmol) and Pd(OH)2 (15g X 8) in methanol (1000 mL) and MeOH/NH3(100 mL) was stirred under H2 (50 psi) at 50 °C for 72 hrs, then the catalyst was removed and the filtrate was concentrated in vacuo and The crude product was chromatographed on silica gel (DCM/MeOH 20:1 - DCM/MeOH/NH3 5:4:1) to give the 2-(trans-4-aminocyclohexyl)propan-2-ol. Yield 210 g, 47.5%, pale yellow solid.

2-(trans-4-Aminocyclohexyl)propan-2-ol Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(trans-4-Aminocyclohexyl)propan-2-ol Suppliers

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View Lastest Price from 2-(trans-4-Aminocyclohexyl)propan-2-ol manufacturers

Pharmahands (Taizhou) Co., Ltd.
Product
TRANS-2-(4-AMINOCYCLOHEXYL)-2-HYDROXYPROPANE 899806-45-2
Price
US $45.00/g/Bag
Min. Order
1g
Purity
99%
Supply Ability
60kg/month
Release date
2020-10-30
Hebei Runbin Biotechnology Co. LTD
Product
TRANS-2-(4-AMINOCYCLOHEXYL)-2-HYDROXYPROPANE 899806-45-2
Price
US $100.00/KG
Min. Order
1KG
Purity
99.9%
Supply Ability
20tons
Release date
2020-09-17

899806-45-2, 2-(trans-4-Aminocyclohexyl)propan-2-olRelated Search:

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  • 2-((1r,4r)-4-aMinocyclohexyl)propan-2-ol
  • TRANS-2-(4-AMINOCYCLOHEXYL)-2-HYDROXYPROPANE
  • 2-(trans-4-AMino-cyclohex...
  • 2-(trans-4-AMino-cyclohexyl)-propan-2-ol
  • 2-(4-aminocyclohexyl)propan-2-ol
  • 2-(4-aminocyclohexyl)-2-propanol
  • 2-(trans-4-Aminocyclohexyl)
  • Cyclohexanemethanol, 4-amino-α,α-dimethyl-, trans-
  • SWF-25
  • SW-25
  • Cyclohexanemethanol,4-amino-a,a-dimethyl-, trans-
  • 899806-45-2