2,4-DICHLORO-5H-PYRROLO[3,2-D]PYRIMIDINE
- Product Name
- 2,4-DICHLORO-5H-PYRROLO[3,2-D]PYRIMIDINE
- CAS No.
- 63200-54-4
- Chemical Name
- 2,4-DICHLORO-5H-PYRROLO[3,2-D]PYRIMIDINE
- Synonyms
- SW-122;SWF-122;2,4-Dichl;oro-5H-pyrroL;2-d]pyriMidine;o[3,2-d]pyrimidine;4-dichloro-5H-pyrrolo[3;2,6-dichloro-9-deazapurine;2,4-Dichloro-5H-pyrrolo[3...;2,4-Dichloropyrrolo[3,2-d]pyrimidine
- CBNumber
- CB5139677
- Molecular Formula
- C6H3Cl2N3
- Formula Weight
- 188.01
- MOL File
- 63200-54-4.mol
2,4-DICHLORO-5H-PYRROLO[3,2-D]PYRIMIDINE Property
- Melting point:
- 226-228 °C(Solv: water (7732-18-5); methanol (67-56-1))
- Boiling point:
- 306.2±24.0 °C(Predicted)
- Density
- 1.675±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 10.67±0.40(Predicted)
- Appearance
- White to yellow Solid
- InChI
- InChI=1S/C6H3Cl2N3/c7-5-4-3(1-2-9-4)10-6(8)11-5/h1-2,9H
- InChIKey
- MVTLFDKTYGKJEX-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC(Cl)=C2NC=CC2=N1
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D437488
- Product name
- 2,4-Dichloro-5H-pyrrolo[3,2-D]pyrimidine
- Packaging
- 5g
- Price
- $220
- Updated
- 2021/12/16
- Product number
- W7523
- Product name
- 2,4-Dichloro-5H-pyrrolo[3,2-d]pyrimidine
- Packaging
- 1g
- Price
- $36
- Updated
- 2021/12/16
- Product number
- CS-W003450
- Product name
- 2,4-Dichloro-5H-pyrrolo[3,2-d]pyrimidine
- Purity
- 99.99%
- Packaging
- 5g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- FD16042
- Product name
- 2,4-Dichloro-5H-pyrrolo[3,2-d]pyrimidine
- Packaging
- 1g
- Price
- $53
- Updated
- 2021/12/16
- Product number
- FD16042
- Product name
- 2,4-Dichloro-5H-pyrrolo[3,2-d]pyrimidine
- Packaging
- 2g
- Price
- $84
- Updated
- 2021/12/16
2,4-DICHLORO-5H-PYRROLO[3,2-D]PYRIMIDINE Chemical Properties,Usage,Production
Uses
2,4-Dichloro-5H-pyrrolo[3,2-d]pyrimidine is an organic intermediate. It can be used to prepare a pyrrolo[3,2-d]pyrimidinone analogue, which is a potent DPP-IV inhibitor that is able to effectively lower blood glucose without causing risks such as weight gain and hypoglycaemia, and achieve prolonged therapeutic control of blood glucose.
Synthesis
65996-50-1
63200-54-4
1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione (0.38 g, 2.52 mmol) was used as starting material and suspended in phosphorus trichloride (30 mL). The suspension was heated to 120°C and the reaction was carried out for 6 h, during which the mixture gradually changed to a clarified homogeneous solution. Upon completion of the reaction, the mixture was cooled to room temperature and the excess phosphorus trichloride was subsequently removed under vacuum. The residue was cooled in an ice bath and cold ammonium hydroxide solution (30 mL, pH = 8) was slowly added and stirred under this condition for 30 minutes. At the end of the reaction, the precipitate was collected by filtration and washed with cold water. Finally, the resulting solid was dried under vacuum to afford the target product 2,4-dichloro-5H-pyrrolo[3,2-d]pyrimidine (0.33 g, 70% yield).
References
[1] Journal of Heterocyclic Chemistry, 1987, vol. 24, p. 821 - 827
[2] Patent: WO2009/62258, 2009, A1. Location in patent: Page/Page column 98
[3] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 7, p. 2113 - 2122
[4] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 15, p. 4354 - 4363
[5] Patent: US2016/257696, 2016, A1. Location in patent: Paragraph 0069-0070
2,4-DICHLORO-5H-PYRROLO[3,2-D]PYRIMIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,4-DICHLORO-5H-PYRROLO[3,2-D]PYRIMIDINE manufacturers
- Product
- 2,4-Dichloropyrrolo[3,2-d]pyrimidine 63200-54-4
- Price
- US $2.00-5.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-07-17
- Product
- 2,4-Dichloro-5H-pyrrolo[3,2-D]pyrimidine 63200-54-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-05-14
- Product
- 2,4-DICHLORO-5H-PYRROLO[3,2-D]PYRIMIDINE 63200-54-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10