4-Aminopyrazolo[3,4-d]pyrimidine

Product Name: 4-Aminopyrazolo[3,4-d]pyrimidine
CAS No.: 2380-63-4
Chemical Name: 4-Aminopyrazolo[3,4-d]pyrimidine
Synonyms: 1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE;4-app;4 APP;nsc1393;NSC 1393;4-Aminopyra;Aminopurinol;Pyrazoloadenine;TIMTEC-BB SBB004205;ADENINE ANTIMETABOLITE
CBNumber: CB3112436
Molecular Formula: C5H5N5
Formula Weight: 135.13
MOL File: 2380-63-4.mol

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4-Aminopyrazolo[3,4-d]pyrimidine Property

Melting point:: >325 °C(lit.)
Boiling point:: 238.81°C (rough estimate)
Density: 1.3795 (rough estimate)
refractive index: 1.7000 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: soluble in DMSO
pka: 12.12±0.20(Predicted)
form: powder to crystal
color: White to Orange to Green
Water Solubility: Insoluble in water.
BRN: 5824
InChIKey: LHCPRYRLDOSKHK-UHFFFAOYSA-N
CAS DataBase Reference: 2380-63-4(CAS DataBase Reference)
NIST Chemistry Reference: 1H-pyrazolo[3,4-d]pyrimidin-4-amine(2380-63-4)
EPA Substance Registry System: 1H-Pyrazolo[3,4-d]pyrimidin-4-amine (2380-63-4)

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Safety

Hazard Codes: T
Risk Statements: 25-36/37/38-23/24/25
Safety Statements: 26-36/37/39-45-22-36
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: UR0717000
TSCA: Yes
HazardClass: 6.1
PackingGroup: III
HS Code: 29335990
Toxicity: LD50 oral in rat: 141mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: A1041
Product name: 4-Aminopyrazolo[3,4-d]pyrimidine
Purity: >97.0%(HPLC)(T)
Packaging: 100mg
Price: $33
Updated: 2025/07/31

TCI Chemical

Product number: A1041
Product name: 4-Aminopyrazolo[3,4-d]pyrimidine
Packaging: 1G
Price: $44
Updated: 2025/07/31

TCI Chemical

Product number: A1041
Product name: 4-Aminopyrazolo[3,4-d]pyrimidine
Packaging: 5G
Price: $132
Updated: 2025/07/31

TRC

Product number: A628970
Product name: 4-Aminopyrazolo[3,4-d]pyrimidine
Packaging: 1g
Price: $50
Updated: 2021/12/16

TRC

Product number: A628970
Product name: 4-Aminopyrazolo[3,4-d]pyrimidine
Packaging: 5g
Price: $80
Updated: 2021/12/16

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4-Aminopyrazolo[3,4-d]pyrimidine Chemical Properties,Usage,Production

Description

4-aminopyrazolo[3,4-d]pyrimidine (4-APP), the isomer of adenine with the five-membered ring in the pyrazole configuration, is by far the most potent inhibitor of both enzymatic reactions catalyzed by Stx1. It is also a new type of mTOR inhibitor. The 4-aminopyrazolo[3,4-d]pyrimidines, a well-characterized class of compounds for tyrosine kinase inhibition, were used as a Src inhibitor module that blocks the adenosine binding site[1-2].

Chemical Properties

Light Tan Solid

Uses

4-Amino-1H-pyrazolo[3,4-d]pyrimidine decreases serum cholesterol markedly in rats.

Hazard

4-Aminopyrazolo[3,4-d]pyrimidine is harmful, irritating to the eyes and skin, and may cause respiratory irritation by inhalation. It is toxic if swallowed.

Synthesis

5399-92-8

2380-63-4

4-Chloro-1H-pyrazolo[3,4-d]pyrimidine (200 mg, 1.29 mmol) was used as starting material and dissolved in tetrahydrofuran (THF, 2.0 mL). Subsequently, ammonium hydroxide (2.0 mL) was added to this solution. The reaction mixture was stirred at 20 to 30 °C for 2 hours. After the reaction was completed, the mixture was concentrated. The concentrate was ground with acetonitrile (MeCN, 0.5 mL) and the product was subsequently collected by filtration to afford 4-aminopyrazolo[3,4-d]pyrimidine (37) as a red solid (100 mg, 57% yield).

References

[1] M Brigotti. “4-Aminopyrazolo[3,4-d]pyrimidine (4-APP) as a novel inhibitor of the RNA and DNA depurination induced by Shiga toxin 1.” Nucleic Acids Research 28 12 (2000): 2383–8.
[2] Ho Jin Lee. “Development of a 4-aminopyrazolo[3,4-d]pyrimidine-based dual IGF1R/Src inhibitor as a novel anticancer agent with minimal toxicity.” Molecular Cancer 17 1 (2018): 50.

4-Aminopyrazolo[3,4-d]pyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Aminopyrazolo[3,4-d]pyrimidine Suppliers

Americas 1 Austria 1 Belgium 1 Canada 2 China 334 Czech Republic 1 Europe 2 France 2 Germany 8 India 24 Japan 3 South Korea 1 Switzerland 2 The Netherlands 2 United Kingdom 13 United States 44 Global 441

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View Lastest Price from 4-Aminopyrazolo[3,4-d]pyrimidine manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-Aminopyrazolo[3,4-d]pyrimidine 2380-63-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-13

Shaanxi Xianhe Biotech Co., Ltd

Product: 4-Aminopyrazolo[3,4-d]pyrimidine 2380-63-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 1000kg
Release date: 2025-04-17

Hubei Lidu New Material Technology Co., Ltd

Product: 4-Aminopyrazolo[3,4-d]pyrimidine 2380-63-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 20TON
Release date: 2024-12-11

2380-63-4, 4-Aminopyrazolo[3,4-d]pyrimidineRelated Search:

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2380-63-4

Building Blocks

Heterocyclic Building Blocks

Pyrimidines

Heterocyclic Compounds

Heterocycles

PYRIMIDINE

Pyridines, Pyrimidines, Purines and Pteredines

Heterocycle-Pyrimidine series