4-Aminopyrazolo[3,4-d]pyrimidine

Product Name: 4-Aminopyrazolo[3,4-d]pyrimidine
CAS No.: 2380-63-4
Chemical Name: 4-Aminopyrazolo[3,4-d]pyrimidine
Synonyms: 1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE;4-app;4 APP;nsc1393;NSC 1393;4-Aminopyra;Aminopurinol;Pyrazoloadenine;TIMTEC-BB SBB004205;ADENINE ANTIMETABOLITE
CBNumber: CB3112436
Molecular Formula: C5H5N5
Formula Weight: 135.13
MOL File: 2380-63-4.mol

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4-Aminopyrazolo[3,4-d]pyrimidine Property

Melting point:: >325 °C(lit.)
Boiling point:: 238.81°C (rough estimate)
Density: 1.3795 (rough estimate)
refractive index: 1.7000 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: soluble in DMSO
pka: 12.12±0.20(Predicted)
form: powder to crystal
color: White to Orange to Green
Water Solubility: Insoluble in water.
BRN: 5824
InChIKey: LHCPRYRLDOSKHK-UHFFFAOYSA-N
CAS DataBase Reference: 2380-63-4(CAS DataBase Reference)
NIST Chemistry Reference: 1H-pyrazolo[3,4-d]pyrimidin-4-amine(2380-63-4)
EPA Substance Registry System: 1H-Pyrazolo[3,4-d]pyrimidin-4-amine (2380-63-4)

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Safety

Hazard Codes: T
Risk Statements: 25-36/37/38-23/24/25
Safety Statements: 26-36/37/39-45-22-36
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: UR0717000
TSCA: Yes
HazardClass: 6.1
PackingGroup: III
HS Code: 29335990
Toxicity: LD50 oral in rat: 141mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: A1041
Product name: 4-Aminopyrazolo[3,4-d]pyrimidine
Purity: >97.0%(HPLC)(T)
Packaging: 100mg
Price: $33
Updated: 2024/03/01

TCI Chemical

Product number: A1041
Product name: 4-Aminopyrazolo[3,4-d]pyrimidine
Packaging: 1G
Price: $44
Updated: 2024/03/01

TCI Chemical

Product number: A1041
Product name: 4-Aminopyrazolo[3,4-d]pyrimidine
Packaging: 5G
Price: $132
Updated: 2024/03/01

Alfa Aesar

Product number: L03519
Product name: 4-Amino-1H-pyrazolo[3,4-d]pyrimidine, 98%
Packaging: 5g
Price: $253.05
Updated: 2023/01/06

Alfa Aesar

Product number: L03519
Product name: 4-Amino-1H-pyrazolo[3,4-d]pyrimidine, 98%
Packaging: 250mg
Price: $23
Updated: 2021/12/16

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4-Aminopyrazolo[3,4-d]pyrimidine Chemical Properties,Usage,Production

Description

4-aminopyrazolo[3,4-d]pyrimidine (4-APP), the isomer of adenine with the five-membered ring in the pyrazole configuration, is by far the most potent inhibitor of both enzymatic reactions catalyzed by Stx1. It is also a new type of mTOR inhibitor. The 4-aminopyrazolo[3,4-d]pyrimidines, a well-characterized class of compounds for tyrosine kinase inhibition, were used as a Src inhibitor module that blocks the adenosine binding site[1-2].

Chemical Properties

Light Tan Solid

Uses

4-Amino-1H-pyrazolo[3,4-d]pyrimidine decreases serum cholesterol markedly in rats.

References

[1] M Brigotti. “4-Aminopyrazolo[3,4-d]pyrimidine (4-APP) as a novel inhibitor of the RNA and DNA depurination induced by Shiga toxin 1.” Nucleic Acids Research 28 12 (2000): 2383–8.
[2] Ho Jin Lee. “Development of a 4-aminopyrazolo[3,4-d]pyrimidine-based dual IGF1R/Src inhibitor as a novel anticancer agent with minimal toxicity.” Molecular Cancer 17 1 (2018): 50.

4-Aminopyrazolo[3,4-d]pyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Aminopyrazolo[3,4-d]pyrimidine Suppliers

Americas 1 Austria 1 Belgium 1 Canada 2 China 316 Czech Republic 1 Europe 2 France 2 Germany 8 India 23 Japan 3 South Korea 1 Switzerland 2 The Netherlands 2 United Kingdom 13 United States 44 Global 422

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View Lastest Price from 4-Aminopyrazolo[3,4-d]pyrimidine manufacturers

Hubei Lidu New Material Technology Co., Ltd

Product: 4-Aminopyrazolo[3,4-d]pyrimidine 2380-63-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 20TON
Release date: 2024-12-11

Nanjing Fred Technology Co., Ltd

Product: 4-Aminopyrazolo[3,4-d]pyrimidine 2380-63-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2023-12-28

Hebei Weibang Biotechnology Co., Ltd

Product: 4-Aminopyrazolo[3,4-d]pyrimidine 2380-63-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-13

2380-63-4, 4-Aminopyrazolo[3,4-d]pyrimidineRelated Search:

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TIMTEC-BB SBB004205

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1H-pyrazolo[4,3-e]pyrimidin-4-amine

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4-Aminopyrazolo[3,4-<i>d</i>]pyrimidine

4-Aminopyra

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4 APP

4-Aminopyrazole(3,4-d)pyrimidine

4-Aminopyrazolopyrimidine

4-app

4-d)pyrimidine,4-amino-1h-pyrazolo(

NSC 1393

nsc1393

Pyrazoloadenine

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Aminopurinol

4-Amino-1,2,5,7-tetraaza-1H-indene

4-Aminopyrazolo[3,4-d]pyrimidine,98%

4-AMinopyrazolo[3,4-d]pyriMidine, 97.5%

Pyrazolo[3,4-d]pyrimidin-4-amin

4-Aminopyrazolo[3,4-d]pyrimidine &gt

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1H-Pyrazolo[3,4-d]pyrimidin-4-amine (9CI, ACI)

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IbrutinibIntermediate5

2380-63-4

Building Blocks

Heterocyclic Building Blocks

Pyrimidines

Heterocyclic Compounds

Heterocycles

PYRIMIDINE

Pyridines, Pyrimidines, Purines and Pteredines

Heterocycle-Pyrimidine series