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4-Aminopyrazolo[3,4-d]pyrimidine

Product Name
4-Aminopyrazolo[3,4-d]pyrimidine
CAS No.
2380-63-4
Chemical Name
4-Aminopyrazolo[3,4-d]pyrimidine
Synonyms
1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE;4-app;4 APP;nsc1393;NSC 1393;4-Aminopyra;Aminopurinol;Pyrazoloadenine;TIMTEC-BB SBB004205;ADENINE ANTIMETABOLITE
CBNumber
CB3112436
Molecular Formula
C5H5N5
Formula Weight
135.13
MOL File
2380-63-4.mol
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4-Aminopyrazolo[3,4-d]pyrimidine Property

Melting point:
>325 °C(lit.)
Boiling point:
238.81°C (rough estimate)
Density 
1.3795 (rough estimate)
refractive index 
1.7000 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
soluble in DMSO
pka
12.12±0.20(Predicted)
form 
powder to crystal
color 
White to Orange to Green
Water Solubility 
Insoluble in water.
BRN 
5824
InChIKey
LHCPRYRLDOSKHK-UHFFFAOYSA-N
CAS DataBase Reference
2380-63-4(CAS DataBase Reference)
NIST Chemistry Reference
1H-pyrazolo[3,4-d]pyrimidin-4-amine(2380-63-4)
EPA Substance Registry System
1H-Pyrazolo[3,4-d]pyrimidin-4-amine (2380-63-4)
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Safety

Hazard Codes 
T
Risk Statements 
25-36/37/38-23/24/25
Safety Statements 
26-36/37/39-45-22-36
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
UR0717000
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
III
HS Code 
29335990
Toxicity
LD50 oral in rat: 141mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
A1041
Product name
4-Aminopyrazolo[3,4-d]pyrimidine
Purity
>97.0%(HPLC)(T)
Packaging
100mg
Price
$33
Updated
2024/03/01
TCI Chemical
Product number
A1041
Product name
4-Aminopyrazolo[3,4-d]pyrimidine
Packaging
1G
Price
$44
Updated
2024/03/01
TCI Chemical
Product number
A1041
Product name
4-Aminopyrazolo[3,4-d]pyrimidine
Packaging
5G
Price
$132
Updated
2024/03/01
Alfa Aesar
Product number
L03519
Product name
4-Amino-1H-pyrazolo[3,4-d]pyrimidine, 98%
Packaging
5g
Price
$253.05
Updated
2023/01/06
Alfa Aesar
Product number
L03519
Product name
4-Amino-1H-pyrazolo[3,4-d]pyrimidine, 98%
Packaging
250mg
Price
$23
Updated
2021/12/16
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4-Aminopyrazolo[3,4-d]pyrimidine Chemical Properties,Usage,Production

Description

4-aminopyrazolo[3,4-d]pyrimidine (4-APP), the isomer of adenine with the five-membered ring in the pyrazole configuration, is by far the most potent inhibitor of both enzymatic reactions catalyzed by Stx1. It is also a new type of mTOR inhibitor. The 4-aminopyrazolo[3,4-d]pyrimidines, a well-characterized class of compounds for tyrosine kinase inhibition, were used as a Src inhibitor module that blocks the adenosine binding site[1-2].

Chemical Properties

Light Tan Solid

Uses

4-Amino-1H-pyrazolo[3,4-d]pyrimidine decreases serum cholesterol markedly in rats.

References

[1] M Brigotti. “4-Aminopyrazolo[3,4-d]pyrimidine (4-APP) as a novel inhibitor of the RNA and DNA depurination induced by Shiga toxin 1.” Nucleic Acids Research 28 12 (2000): 2383–8.
[2] Ho Jin Lee. “Development of a 4-aminopyrazolo[3,4-d]pyrimidine-based dual IGF1R/Src inhibitor as a novel anticancer agent with minimal toxicity.” Molecular Cancer 17 1 (2018): 50.

4-Aminopyrazolo[3,4-d]pyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Aminopyrazolo[3,4-d]pyrimidine Suppliers

Americas 1 Austria 1 Belgium 1 Canada 2 China 316 Czech Republic 1 Europe 2 France 2 Germany 8 India 23 Japan 3 South Korea 1 Switzerland 2 The Netherlands 2 United Kingdom 13 United States 44 Global 422
Loba Feinchemie AG
Tel
--
Fax
--
Email
sales@loba.co.at
Country
Austria
ProdList
900
Advantage
61
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View Lastest Price from 4-Aminopyrazolo[3,4-d]pyrimidine manufacturers

Hubei Lidu New Material Technology Co., Ltd
Product
4-Aminopyrazolo[3,4-d]pyrimidine 2380-63-4
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
20TON
Release date
2024-12-11
Nanjing Fred Technology Co., Ltd
Product
4-Aminopyrazolo[3,4-d]pyrimidine 2380-63-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2023-12-28
Hebei Weibang Biotechnology Co., Ltd
Product
4-Aminopyrazolo[3,4-d]pyrimidine 2380-63-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-13

2380-63-4, 4-Aminopyrazolo[3,4-d]pyrimidineRelated Search:

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  • TIMTEC-BB SBB004205
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  • 4-Amino-1H-pyrazolo[3,4-d]pyrimidine,98%
  • 1(H)-4-amine-pyrazolo[3,4-d]pyrimidine
  • 1H-Pyrazolo[3,4-d]pyrimidine-4-ylamine
  • 4-Aminopyrazolo[3,4-d]pyrimidine 98%
  • 1H-pyrazolo[4,3-e]pyrimidin-4-amine
  • 1H-pyrazolo[4,3-e]pyrimidin-4-ylamine
  • 4-Aminopyrazolo[3,4-<i>d</i>]pyrimidine
  • 4-Aminopyra
  • 1H-Pyrazolo[3,4-d]pyrimidine, 4-amino-
  • 4 APP
  • 4-Aminopyrazole(3,4-d)pyrimidine
  • 4-Aminopyrazolopyrimidine
  • 4-app
  • 4-d)pyrimidine,4-amino-1h-pyrazolo(
  • NSC 1393
  • nsc1393
  • Pyrazoloadenine
  • 1H-Pyrazolo[3,4-d]pyrimidin-4-amine (9CI)
  • Adenine antimetabolite, Pyrazolo[3,4-d]pyrimidin-4-amin
  • Aminopurinol
  • 4-Amino-1,2,5,7-tetraaza-1H-indene
  • 4-Aminopyrazolo[3,4-d]pyrimidine,98%
  • 4-AMinopyrazolo[3,4-d]pyriMidine, 97.5%
  • Pyrazolo[3,4-d]pyrimidin-4-amin
  • 4-Aminopyrazolo[3,4-d]pyrimidine &gt
  • 4-Dihydroxybenzylamine hydrobromide
  • 1H-Pyrazolo[3,4-d]pyrimidin-4-amine (9CI, ACI)
  • 4-aminopyrazole and [3,4-d] pyrimidine
  • IbrutinibIntermediate5
  • 2380-63-4
  • Building Blocks
  • Heterocyclic Building Blocks
  • Pyrimidines
  • Heterocyclic Compounds
  • Heterocycles
  • PYRIMIDINE
  • Pyridines, Pyrimidines, Purines and Pteredines
  • Heterocycle-Pyrimidine series