4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine

Product Name: 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine
CAS No.: 479633-63-1
Chemical Name: 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine
Synonyms: Tofacitinib Impurity 20;Tofacitinib-9;Tofacitinib imurity;Tofatinib Impurity 1;Tofatinib Impurity P;Tofacitinib Impurity R;Tofacitinib Impurity 53;4-Chloro-7-tosyl-7H-pyrro...;4-Chloro-7-tosyl-7H-pyrrolo[2;Azilsartan medoxomil impurity345
CBNumber: CB32452480
Molecular Formula: C13H10ClN3O2S
Formula Weight: 307.76
MOL File: 479633-63-1.mol

More

Less

4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine Property

Melting point:: 145.0 to 149.0 °C
Boiling point:: 505.3±60.0 °C(Predicted)
Density: 1.49
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), DMSO (Slightly)
form: powder to crystal
pka: 1.73±0.30(Predicted)
color: White to Orange to Green
InChI: InChI=1S/C13H10ClN3O2S/c1-9-2-4-10(5-3-9)20(18,19)17-7-6-11-12(14)15-8-16-13(11)17/h2-8H,1H3
InChIKey: BTOJSYRZQZOMOK-UHFFFAOYSA-N
SMILES: C1=NC(Cl)=C2C=CN(S(C3=CC=C(C)C=C3)(=O)=O)C2=N1

More

Less

Safety

Hazard Codes: Xn
Risk Statements: 22
HazardClass: IRRITANT
HS Code: 2933599590

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: ADE000077
Product name: 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine
Purity: Aldrich
Packaging: 1g
Price: $761
Updated: 2023/06/20

TCI Chemical

Product number: C3036
Product name: 4-Chloro-7-(p-toluenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidine
Purity: >96.0%(HPLC)(N)
Packaging: 1g
Price: $74
Updated: 2024/03/01

TCI Chemical

Product number: C3036
Product name: 4-Chloro-7-(p-toluenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidine
Purity: >96.0%(HPLC)(N)
Packaging: 5g
Price: $296
Updated: 2023/06/20

Apolloscientific

Product number: OR317249
Product name: 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine
Packaging: 5g
Price: $327
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC10607
Product name: 4-Chloro-7-p-toluenesulphonyl-7H-pyrrolo[2,3-d]pyrimidine
Packaging: 25g
Price: $472.5
Updated: 2021/12/16

More

Less

4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine Chemical Properties,Usage,Production

Uses

4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine is a reagent in the synthesis of (+)-tofacitinib, a selective Janus kinase 3 inhibitor (JAK3) and an immunosuppressant drug.

Synthesis

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine (2kg, 12.96mol) and dichloromethane (40L) were added to the reaction flask at room temperature, stirred and dissolved. Triethylamine (3.88 kg, 38.4 mol) and 4-dimethylamino pyridine (157.6 g, 1.28 mol) were added in that order, and after stirring and dissolved, p-toluenesulfonyl chloride (2.6 kg, 13.6 mol) was added dropwise at 0 °C. The chloromethane (30 L) solution was added dropwise, and the mixture was stirred at room temperature for 30 min. After the TLC was applied, the mixture was washed with water (16L×3). 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine (3.9 kg, yield 97.7%) was obtained after drying under reduced pressure.

4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine Suppliers

Americas 1 China 313 Europe 1 Germany 3 India 25 Japan 2 Switzerland 2 The Netherlands 1 United Kingdom 7 United States 25 Global 380

Bayee Biotech (Anqing) Co., Ltd.

Tel: 0556-5032306 18917961636
Fax: +86-556-5032307
Email: wtx@bayeebio.com
Country: China
ProdList: 253
Advantage: 61

Shanghai Huanfu Industrial Co., Ltd.

Tel: 18001856580
Fax: QQ：2415195517
Email: 2415195517@qq.com
Country: China
ProdList: 43
Advantage: 58

Anhui Lianchuang Biological Medicine Co.,Ltd

Tel: 0551-68779238 18056025720
Email: sales3@lcywhx.com
Country: China
ProdList: 168
Advantage: 57

Hangzhou Chemtrue Bio-Tech Co.,Ltd.

Tel: 0571-86828652 19967494293
Fax: 0571-83522824
Email: sales@chemtrue-bio.com
Country: China
ProdList: 314
Advantage: 58

Changzhou Langyi Biomedical Technology Co., Ltd.

Tel: 13706129682
Email: tiffany@langyupharm.com
Country: China
ProdList: 70
Advantage: 58

FUXIN QINGJISHENG SCIENCE AND TECHNOLOGY CO.,LID

Tel: 13365798276
Email: hxy696128@126.com
Country: China
ProdList: 160
Advantage: 58

Jinan Lide Pharmaceutical Technology Co., Ltd.

Tel: 0531-68654990 18560195202
Fax: 053168654990
Email: leadgxm@leadchem.net
Country: China
ProdList: 159
Advantage: 58

ChemFuture PharmaTech (Jiangsu) Ltd

Tel: 5108538618
Fax: 86 510 85386988-8017
Email: suger.wang@chemfuture.com
Country: China
ProdList: 822
Advantage: 65

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44751
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Email: sales@capotchem.com
Country: China
ProdList: 18217
Advantage: 66

More

Less

View Lastest Price from 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine manufacturers

Henan Fengda Chemical Co., Ltd

Product: 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine 479633-63-1
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-15

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine 479633-63-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-01-18

Henan Aochuang Chemical Co.,Ltd.

Product: 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine 479633-63-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-08

479633-63-1, 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidineRelated Search:

N-Methyl-N-((3S,4S)-4-Methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyriMidin-4-aMine 7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]-7-[(4-Met hylphenyl)sulfonyl]- (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride DEAZAPURINE 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine Trifluorothymine 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine 2,4-DICHLORO-7H-PYRROLO2,3-DPYRIMIDINE 4-Amino-7H-pyrrolo[2,3-d]pyrimidine 2-Amino-4-chloropyrrolo[2,3-d]pyrimidine 2-Thiouracil 2,4-DICHLORO-5H-PYRROLO[3,2-D]PYRIMIDINE 4-Chloro-5-iodo-7H-pyrrol[2,3-d]pyrimidine Pyrrolo[2,3-d]pyrimidin-4-ol N4-Benzoylcytosine 4-Aminopyrazolo[3,4-d]pyrimidine 5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine Tofacitinib Impurity T

Tofacitinib Impurity R

4-Chloro-7-(p-tolylsulfonyl)pyrrolo[2,3-d]pyrimidine

4-CHLORO-7-[(4-METHYLPHENYL)SULFONYL]-7H-PYRROLO[2,3-D]PYRIMIDINE

4-CHLORO-7-TOSYL-7H-PYRROLO[2,3-D]PYRIMIDINE

4-Chloro-7-tosyl-7H-pyrro...

4-Chloro-7-[(4-methylbenzene)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine

4-Chloro-7-p-toluenesulphonyl-7H-pyrrolo[2,3-d]pyrimidine

7H-Pyrrolo[2,3-D]pyriMidine,4-chloro-7-[(4-Methylphenyl)sulfonyl]-

4-Chloro-7-tosyl-7H-pyrrolo[2

4-chloro-7-(4-methylphenyl)sulfonylpyrrolo[2,3-d]pyrimidine

Tofacitinib-9

4-Chloro-7-[(4-methylbenzene)sulfonyl]pyrrolo[2,3-d]pyrimidine

Tofacitinib imurity

3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-2-yl) amino)piperidin-1-yl)-3-oxopropanenitrile

4-Chloro-7-(p-toluenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidine

4-Chloro-7-(toluene-4-sulfonyl)-7H-pyrrolo[2,3-d]pyrimidine

Tofacitinib Impurity 53

Tofacitinib Impurity 20

4-Chloro-7-(p-toluenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidine &gt

4-Chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrim...

Azilsartan medoxomil impurity345

Tofatinib Impurity 1

Tofatinib Impurity P

479633-63-1

Heterocycle-Pyrimidine series