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2-Amino-4-chloropyrrolo[2,3-d]pyrimidine

Product Name
2-Amino-4-chloropyrrolo[2,3-d]pyrimidine
CAS No.
84955-31-7
Chemical Name
2-Amino-4-chloropyrrolo[2,3-d]pyrimidine
Synonyms
4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDIN-2-AMINE;6-CHLORO-7-DEAZAGUANINE;3-d]pyriMidin-2-aMine;2-Amino-4-Chloro-7H-pyrro...;2-amino-6-chloro-7-deazapurine;-Amino-4-chloropyrrolo[2,3-d]pyrimidine;2-Amino-4-chloropyrrolo[2,3-d]pyrimidine;4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-2-ylam;4-chloro-1H-pyrrolo[2,3-d]pyriMidin-2-aMine;2-Amino-4-Chloro-7H-pyrrolo[2,3-d]pyrimidine
CBNumber
CB6270612
Molecular Formula
C6H5ClN4
Formula Weight
168.58
MOL File
84955-31-7.mol
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2-Amino-4-chloropyrrolo[2,3-d]pyrimidine Property

Melting point:
215-217°C
Boiling point:
346.6±52.0 °C(Predicted)
Density 
1.82±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly, Sonicated)
pka
10.68±0.20(Predicted)
form 
Powder
color 
Pale yellow to yellow
Stability:
Hygroscopic
InChI
InChI=1S/C6H5ClN4/c7-4-3-1-2-9-5(3)11-6(8)10-4/h1-2H,(H3,8,9,10,11)
InChIKey
VIVLSUIQHWGALQ-UHFFFAOYSA-N
SMILES
C1(N)=NC(Cl)=C2C=CNC2=N1
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Safety

Hazard Codes 
Xi
Risk Statements 
36
Safety Statements 
26
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
C365170
Product name
6-Chloro-7-deazaguanine
Packaging
10g
Price
$85
Updated
2021/12/16
Usbiological
Product number
C4979
Product name
6-Chloro-7-deazaguanine
Packaging
200mg
Price
$403
Updated
2021/12/16
Matrix Scientific
Product number
066665
Product name
4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine
Packaging
1g
Price
$25
Updated
2021/12/16
Apolloscientific
Product number
OR17061
Product name
2-Amino-4-chloro-7H-pyrrolo[2,3-d]pyrimidine
Purity
95+%
Packaging
1g
Price
$34
Updated
2021/12/16
SynQuest Laboratories
Product number
3H30-5-Y8
Product name
2-Amino-4-chloro-7H-pyrrolo[2,3-d]pyrimidine
Purity
95.0%
Packaging
1g
Price
$37
Updated
2021/12/16
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2-Amino-4-chloropyrrolo[2,3-d]pyrimidine Chemical Properties,Usage,Production

Chemical Properties

White Crystalline Solid

Uses

6-Chloro-7-deazaguanine (cas# 84955-31-7) is a compound useful in organic synthesis.

Synthesis

7355-55-7

84955-31-7

2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine (10.0 g, 66.6 mmol) was added to 100 mL of phosphorus oxychloride (POCl3) and the reaction was carried out at reflux for 2 hours. After completion of the reaction, the solvent was removed by rotary evaporator. After the reaction mixture was cooled to room temperature, it was slowly poured into 120 mL of ice water and the solid product was collected by filtration. The filter cake was washed with ice water and the pH of the filtrate was subsequently adjusted to 2 with ammonia solution and cooled in an ice bath for 2 hours to promote precipitation. The solid product was filtered again and washed sequentially with 10 mL of ice water and 30 mL of ether, resulting in 8.7 g of 2-amino-4-chloropyrrolo[2,3-d]pyrimidine in 78% yield.

References

[1] Liebigs Annalen der Chemie, 1987, p. 15 - 19
[2] Angewandte Chemie - International Edition, 2007, vol. 46, # 13, p. 2325 - 2327
[3] Patent: CN103819523, 2016, B. Location in patent: Paragraph 0048; 0049; 0050
[4] Liebigs Annalen der Chemie, 1983, # 1, p. 137 - 146
[5] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 7, p. 2260 - 2264

2-Amino-4-chloropyrrolo[2,3-d]pyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Amino-4-chloropyrrolo[2,3-d]pyrimidine Suppliers

Canada 2 China 183 Germany 3 India 1 United Kingdom 3 United States 24 Global 216
Shanghai Arbor Chemical Co., Ltd.
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021-60451683 15021268886
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+86-21-60451682
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sales@arborchemical.com
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China
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Established by Hangzhou Boman Biochem Tech Co., Ltd
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13588048971
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sales@bomanbiochem.com
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China
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Shandong Shenganbei New Energy Co. , Ltd. . Nanjing branch
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18761883648
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sab202211@163.com
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China
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Aikon International Limited
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025-58851090 15955137747
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(6)02557626880
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sales01@aikonchem.com
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China
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J & K SCIENTIFIC LTD.
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18210857532; 18210857532
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jkinfo@jkchemical.com
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3B Pharmachem (Wuhan) International Co.,Ltd.
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3bsc@sina.com
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China
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Capot Chemical Co., Ltd
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+86 (0) 571 85 58 67 18
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0086-571-85864795
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China
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Jia Xing Isenchem Co.,Ltd
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0573-85285100 18627885956
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0573-85285100
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isenchem@163.com
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China
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Accela ChemBio Co.,Ltd.
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021-50795510 4000665055
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021-50795055
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sales@accelachem.com
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China
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Shanghai Boc Chemical Co.,Ltd
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021-34975603-808 18721111801
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+86-21-34975602-805
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sales@bocpharma.com
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China
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1009
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View Lastest Price from 2-Amino-4-chloropyrrolo[2,3-d]pyrimidine manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
2-Amino-4-chloropyrrolo[2,3-d]pyrimidine 84955-31-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-28
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-Amino-4-chloropyrrolo[2,3-d]pyrimidine 84955-31-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-Amino-4-chloropyrrolo[2,3-d]pyrimidine 84955-31-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

84955-31-7, 2-Amino-4-chloropyrrolo[2,3-d]pyrimidineRelated Search:

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