2-Amino-4-chloropyrrolo[2,3-d]pyrimidine
- Product Name
- 2-Amino-4-chloropyrrolo[2,3-d]pyrimidine
- CAS No.
- 84955-31-7
- Chemical Name
- 2-Amino-4-chloropyrrolo[2,3-d]pyrimidine
- Synonyms
- 4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDIN-2-AMINE;6-CHLORO-7-DEAZAGUANINE;3-d]pyriMidin-2-aMine;2-Amino-4-Chloro-7H-pyrro...;2-amino-6-chloro-7-deazapurine;-Amino-4-chloropyrrolo[2,3-d]pyrimidine;2-Amino-4-chloropyrrolo[2,3-d]pyrimidine;4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-2-ylam;4-chloro-1H-pyrrolo[2,3-d]pyriMidin-2-aMine;2-Amino-4-Chloro-7H-pyrrolo[2,3-d]pyrimidine
- CBNumber
- CB6270612
- Molecular Formula
- C6H5ClN4
- Formula Weight
- 168.58
- MOL File
- 84955-31-7.mol
2-Amino-4-chloropyrrolo[2,3-d]pyrimidine Property
- Melting point:
- 215-217°C
- Boiling point:
- 346.6±52.0 °C(Predicted)
- Density
- 1.82±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly, Sonicated)
- pka
- 10.68±0.20(Predicted)
- form
- Powder
- color
- Pale yellow to yellow
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C6H5ClN4/c7-4-3-1-2-9-5(3)11-6(8)10-4/h1-2H,(H3,8,9,10,11)
- InChIKey
- VIVLSUIQHWGALQ-UHFFFAOYSA-N
- SMILES
- C1(N)=NC(Cl)=C2C=CNC2=N1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- C365170
- Product name
- 6-Chloro-7-deazaguanine
- Packaging
- 10g
- Price
- $85
- Updated
- 2021/12/16
- Product number
- C4979
- Product name
- 6-Chloro-7-deazaguanine
- Packaging
- 200mg
- Price
- $403
- Updated
- 2021/12/16
- Product number
- 066665
- Product name
- 4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine
- Packaging
- 1g
- Price
- $25
- Updated
- 2021/12/16
- Product number
- OR17061
- Product name
- 2-Amino-4-chloro-7H-pyrrolo[2,3-d]pyrimidine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $34
- Updated
- 2021/12/16
- Product number
- 3H30-5-Y8
- Product name
- 2-Amino-4-chloro-7H-pyrrolo[2,3-d]pyrimidine
- Purity
- 95.0%
- Packaging
- 1g
- Price
- $37
- Updated
- 2021/12/16
2-Amino-4-chloropyrrolo[2,3-d]pyrimidine Chemical Properties,Usage,Production
Chemical Properties
White Crystalline Solid
Uses
6-Chloro-7-deazaguanine (cas# 84955-31-7) is a compound useful in organic synthesis.
Synthesis
7355-55-7
84955-31-7
2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine (10.0 g, 66.6 mmol) was added to 100 mL of phosphorus oxychloride (POCl3) and the reaction was carried out at reflux for 2 hours. After completion of the reaction, the solvent was removed by rotary evaporator. After the reaction mixture was cooled to room temperature, it was slowly poured into 120 mL of ice water and the solid product was collected by filtration. The filter cake was washed with ice water and the pH of the filtrate was subsequently adjusted to 2 with ammonia solution and cooled in an ice bath for 2 hours to promote precipitation. The solid product was filtered again and washed sequentially with 10 mL of ice water and 30 mL of ether, resulting in 8.7 g of 2-amino-4-chloropyrrolo[2,3-d]pyrimidine in 78% yield.
References
[1] Liebigs Annalen der Chemie, 1987, p. 15 - 19
[2] Angewandte Chemie - International Edition, 2007, vol. 46, # 13, p. 2325 - 2327
[3] Patent: CN103819523, 2016, B. Location in patent: Paragraph 0048; 0049; 0050
[4] Liebigs Annalen der Chemie, 1983, # 1, p. 137 - 146
[5] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 7, p. 2260 - 2264
2-Amino-4-chloropyrrolo[2,3-d]pyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
2-Amino-4-chloropyrrolo[2,3-d]pyrimidine Suppliers
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View Lastest Price from 2-Amino-4-chloropyrrolo[2,3-d]pyrimidine manufacturers
- Product
- 2-Amino-4-chloropyrrolo[2,3-d]pyrimidine 84955-31-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-28
- Product
- 2-Amino-4-chloropyrrolo[2,3-d]pyrimidine 84955-31-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 2-Amino-4-chloropyrrolo[2,3-d]pyrimidine 84955-31-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09