Propanamide, N-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl-

Product Name: Propanamide, N-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl-
CAS No.: 149765-16-2
Chemical Name: Propanamide, N-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl-
Synonyms: N2-Pivaloyl-4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyriMidine;4-chloro-5-iodo-2-pivaloylamino-7H-pyrrolo[2,3-d]pyrimidine;N-(4-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyriMidin-2-yl)pivalaMide;Propanamide, N-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2...;N-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl-;N2-Pivaloyl-2-amino-?4-?chloro-?5-?iodo-?7H-?pyrrolo[2,?3-?d]?pyrimidine;N-(4-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyriMidin-2-yl)-2,2-diMethyl propanaMide;N-(4-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethylpropionamide;Propanamide, N-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl-
CBNumber: CB31509307
Molecular Formula: C11H12ClIN4O
Formula Weight: 378.6
MOL File: 149765-16-2.mol

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Propanamide, N-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl- Property

Melting point:: 240 °C(Solv: methanol (67-56-1))
Density: 1.90±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 5.97±0.40(Predicted)
Appearance: Off-white to yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: C349550
Product name: N-(4-Chloro-5-iodo-7h-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethylpropionamide
Packaging: 100mg
Price: $140
Updated: 2021/12/16

AK Scientific

Product number: X7292
Product name: N-(4-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl-propanamide
Packaging: 250mg
Price: $173
Updated: 2021/12/16

Matrix Scientific

Product number: 072622
Product name: N-(4-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethylpropionamide
Purity: 95+%
Packaging: 500mg
Price: $254
Updated: 2021/12/16

Matrix Scientific

Product number: 072622
Product name: N-(4-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethylpropionamide
Purity: 95+%
Packaging: 1g
Price: $391
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0143563
Product name: N-(4-CHLORO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-2-YL)-2,2-DIMETHYLPROPIONAMIDE
Purity: 95.00%
Packaging: 250MG
Price: $1034.88
Updated: 2021/12/16

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Propanamide, N-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl- Chemical Properties,Usage,Production

Synthesis

149765-15-1

149765-16-2

Step 4. Synthesis of N-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethylpropanamide An anhydrous tetrahydrofuran (2L) solution of N-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethylpropanamide (101 g, 0.40 mol) was treated with N-iodosuccinimide (98.9 g, 0.44 mol, 1.1 eq.) under nitrogen protection and the reaction was stirred at room temperature for 40 min. After completion of the reaction, the solvent was removed by evaporation and the residue was dissolved in dichloromethane (1.5 L) and washed sequentially with sodium sulfite solution (500 mL x 3) and saturated saline (300 mL x 3). The organic phase was dried over anhydrous sodium sulfate, concentrated, and recrystallized from methanol to give the title compound as a white powder (122 g, 81% yield, HPLC purity: 98.2%). Retention time (tR): 6.19 min. 1H-NMR (DMSO-d6) δ: 12.65 (broad single peak, 1H), 10.11 (broad single peak, 1H), 7.76 (double peak, 1H), 1.24 (single peak, 9H).

References

[1] Synthesis, 2004, # 8, p. 1203 - 1210
[2] Heterocycles, 1993, vol. 35, # 2, p. 825 - 841
[3] Angewandte Chemie - International Edition, 2007, vol. 46, # 13, p. 2325 - 2327
[4] Patent: US2006/223797, 2006, A1. Location in patent: Page/Page column 83-84
[5] Journal of Medicinal Chemistry, 2012, vol. 55, # 17, p. 7786 - 7795

Propanamide, N-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl- Preparation Products And Raw materials

Raw materials

Preparation Products

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Propanamide, N-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl- Suppliers

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149765-16-2, Propanamide, N-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl-Related Search:

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149765-16-2

C11H12ClIN4O