N-(4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDIN-2-YL)-2,2-DIMETHYLPROPIONAMIDE

Product Name: N-(4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDIN-2-YL)-2,2-DIMETHYLPROPIONAMIDE
CAS No.: 149765-15-1
Chemical Name: N-(4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDIN-2-YL)-2,2-DIMETHYLPROPIONAMIDE
Synonyms: N-(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-2-yl);N2-Pivaloyl-4-chloro-7H-pyrrolo[2,3-d]pyriMidine;N-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-yl)pivalamide;N-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethylpro...;N-(4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDIN-2-YL)-2,2-DIMETHYLPROPIONAMIDE;N-(4-Chloro-7H-pyrrolo[2,3-d]pyriMidin-2-yl)-2,2-diMethyl propanaMide;PropanaMide, N-(4-chloro-7H-pyrrolo[2,3-d]pyriMidin-2-yl)-2,2-diMethyl-;N-(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl propanamide, N2-Pivaloyl-2-amino-4-chloro-7H-pyrrolo[2,3-d]pyrimidine
CBNumber: CB62455952
Molecular Formula: C11H13ClN4O
Formula Weight: 252.7
MOL File: 149765-15-1.mol

More

Less

N-(4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDIN-2-YL)-2,2-DIMETHYLPROPIONAMIDE Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TRC

Product number: C383673
Product name: N-(4-Chloro-7H-Pyrrolo[2,3-D]Pyrimidin-2-Yl)-2,2-Dimethylpropionamide
Packaging: 100mg
Price: $175
Updated: 2021/12/16

Matrix Scientific

Product number: 072623
Product name: N-(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethylpropionamide
Purity: 95+%
Packaging: 1g
Price: $685
Updated: 2021/12/16

AK Scientific

Product number: W3271
Product name: N-(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethylpropionamide
Packaging: 5g
Price: $1003
Updated: 2021/12/16

Ambeed

Product number: A106215
Product name: N-(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethylpropionamide
Purity: 95%
Packaging: 100mg
Price: $45
Updated: 2021/12/16

Ambeed

Product number: A106215
Product name: N-(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethylpropionamide
Purity: 95%
Packaging: 250mg
Price: $67
Updated: 2021/12/16

More

Less

N-(4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDIN-2-YL)-2,2-DIMETHYLPROPIONAMIDE Chemical Properties,Usage,Production

Synthesis

137281-08-4

149765-15-1

Step 3. Synthesis of N-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethylpropanamide N-(4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethylpropanamide (210 g, 0.90 mol), phosphorus oxychloride (POCl3, 828 g, 5.40 mol, 503 mL, 6.0 equiv), benzyltriethylammonium chloride (411 g, 1.80 mol), N,N- dimethylaniline (220 g, 231 mL, 1.80 mol) and acetonitrile (2.0 L) were mixed and heated to reflux for 40-60 min, the reaction was monitored by HPLC. Upon completion of the reaction, the solvent was evaporated on a rotary evaporator and the residue was carefully (note: exothermic and corrosive) added slowly to ice water (16 L). The pH was adjusted to 7 with solid sodium hydroxide (NaOH) and the resulting precipitate was collected by filtration. The precipitate was dried to give N-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethylpropanamide (159 g, 70% yield, 100% HPLC purity). Retention time (tR): 5.37 min. 1H-NMR (DMSO-d6) δ 12.35 (broad single peak, 1H), 10.06 (broad single peak, 1H), 7.54 (quadruple peak, 1H), 6.52 (quadruple peak, 1H), 1.25 (single peak, 9H).

References

[1] Patent: US2006/223797, 2006, A1. Location in patent: Page/Page column 83-84
[2] Journal of Medicinal Chemistry, 2012, vol. 55, # 17, p. 7786 - 7795
[3] Journal of Medicinal Chemistry, 2003, vol. 46, # 4, p. 591 - 600

N-(4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDIN-2-YL)-2,2-DIMETHYLPROPIONAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

N-(4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDIN-2-YL)-2,2-DIMETHYLPROPIONAMIDE Suppliers

China 36 India 1 Switzerland 1 United States 6 Global 44

Nanjing Baifuli Technology Co., Ltd.

Tel: 25-25-58740604 15951658055
Fax: +86-25-58356858
Email: sales@unisyn.cn
Country: China
ProdList: 591
Advantage: 58

EnliPharma Technology Co., Ltd

Tel: 0551-66399836 18955197623
Email: sales@enlipharma.com
Country: China
ProdList: 1876
Advantage: 55

Shanghai Kahn Pharmaceutical Co., Ltd.

Tel: 021-34979681; 17701870669
Fax: 021-34979681
Email: 41513101@qq.com
Country: China
ProdList: 1785
Advantage: 55

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

JiangYin Ruisheng Chemical Co., Ltd.

Tel: 13003356808
Fax: QQ:1485751188
Email: 1485751188@qq.com
Country: China
ProdList: 403
Advantage: 55

Capot Chemical Co.,Ltd.

Tel: +86-（0）57185586718; +8613336195806
Fax: +86-571-85864795
Email: sales@capot.com
Country: China
ProdList: 29735
Advantage: 60

Aikon International Limited

Tel: 025-66061636 18013972705
Fax: (3)02557626880
Email: qqyang@aikonchem.com
Country: China
ProdList: 15814
Advantage: 58

Fuyang Ziyi Biological Pharmaceutical Co., Ltd.

Tel: 19308655899; 19308655899
Fax: -
Email: 2677609105@qq.com
Country: China
ProdList: 500
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Zhengzhou Granlen Sciences, ltd.

Tel: 0371-85513397 +86-18610099868
Email: info@granlen.com
Country: China
ProdList: 1890
Advantage: 58

149765-15-1, N-(4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDIN-2-YL)-2,2-DIMETHYLPROPIONAMIDERelated Search:

Propanamide, N-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl- N-(4-Chloro-5-fluoro-3-iodopyridin-2-yl)pivalamide N-[4-(4-Amino-2-ethyl-1H-imidazo[4,5-c]quinolin-1-yl)butyl]-methylesulfonamide N2-Pivaloyl-4-chloro-5-cyano-7H-pyrrolo[2,3-d]pyriMidine 2-Amino-4-chloropyrrolo[2,3-d]pyrimidine N-(4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDIN-2-YL)-2,2-DIMETHYLPROPIONAMIDE

N-(4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDIN-2-YL)-2,2-DIMETHYLPROPIONAMIDE

PropanaMide, N-(4-chloro-7H-pyrrolo[2,3-d]pyriMidin-2-yl)-2,2-diMethyl-

N2-Pivaloyl-4-chloro-7H-pyrrolo[2,3-d]pyriMidine

N-(4-Chloro-7H-pyrrolo[2,3-d]pyriMidin-2-yl)-2,2-diMethyl propanaMide

N-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-yl)pivalamide

N-(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-2-yl)

N-(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethyl propanamide, N2-Pivaloyl-2-amino-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

N-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethylpro...

149765-15-1