2,4-DICHLORO-7H-PYRROLO2,3-DPYRIMIDINE

Product Name: 2,4-DICHLORO-7H-PYRROLO2,3-DPYRIMIDINE
CAS No.: 90213-66-4
Chemical Name: 2,4-DICHLORO-7H-PYRROLO2,3-DPYRIMIDINE
Synonyms: 2,6-Dichloro-7-deazapurine;Tofacitinib-8;oro-7H-pyrroL;4,6-DICHLORO PURINE;o (2,3-d)pyrimidine;Tofatinib Impurity 7;2,6-dichloro-7-deazapurin ;Tofacitinib Intermediate II;2,4-Dichloro-7H-pyrrolo[2...;2,6-Dichloro-7-deazapurine>
CBNumber: CB7418105
Molecular Formula: C6H3Cl2N3
Formula Weight: 188.01
MOL File: 90213-66-4.mol

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2,4-DICHLORO-7H-PYRROLO2,3-DPYRIMIDINE Property

Melting point:: 247-250°C
Boiling point:: 312.0±52.0 °C(Predicted)
Density: 1.79±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Acetone (Slightly), DMSO (Slightly), Methanol (Slightly)
pka: 9.18±0.20(Predicted)
form: Solid
color: Off-White to Yellow
Water Solubility: Soluble in DMSO, ethyl acetate and methanol. Slightly soluble in water.
InChI: InChI=1S/C6H3Cl2N3/c7-4-3-1-2-9-5(3)11-6(8)10-4/h1-2H,(H,9,10,11)
InChIKey: GHXBPCSSQOKKGB-UHFFFAOYSA-N
SMILES: C1(Cl)=NC(Cl)=C2C=CNC2=N1

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Safety

Hazard Codes: T
Risk Statements: 25-36-36/37/38-22
Safety Statements: 26-45-28-36
RIDADR: UN2811
HazardClass: IRRITANT
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: D4284
Product name: 2,6-Dichloro-7-deazapurine
Purity: >98.0%(HPLC)(N)
Packaging: 1g
Price: $33
Updated: 2025/07/31

TCI Chemical

Product number: D4284
Product name: 2,6-Dichloro-7-deazapurine
Purity: >98.0%(HPLC)(N)
Packaging: 5g
Price: $79
Updated: 2025/07/31

Usbiological

Product number: D3530-65
Product name: 2,6-Dichloro-7-deazapurine
Packaging: 500mg
Price: $382
Updated: 2021/12/16

TRC

Product number: D434025
Product name: 2,6-Dichloro-7-deazapurine
Packaging: 25g
Price: $100
Updated: 2021/12/16

AK Scientific

Product number: J92474
Product name: 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine
Packaging: 25g
Price: $112
Updated: 2021/12/16

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2,4-DICHLORO-7H-PYRROLO2,3-DPYRIMIDINE Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Uses

It is used as a pharmaceutical intermediate.

Synthesis

39929-79-8

90213-66-4

General procedure for the synthesis of 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidines from 2,4-dihydroxypyrrolo[2,3-d]pyrimidines: 7H-pyrrolo[2,3-d]pyrimidine-2,4-diol (10.0 g, 66.2 mmol) and toluene (30 ml) were added to a reactor equipped with a stirrer. Phosphoryl chloride (18.5 ml, 198.5 mmol) was added slowly under stirring and the reaction system was subsequently warmed to 70 °C. Diisopropylethylamine (23.0 ml, 132.3 mmol) was added dropwise over 2.5 h to control the exothermic nature of the reaction. After the dropwise addition, the reaction temperature was raised to 106 °C and stirring was continued at this temperature for 16 hours. After completion of the reaction, the mixture was cooled to 25 °C and then slowly poured into a flask containing water (230 ml) and ethyl acetate (120 ml) and stirred overnight at room temperature. The reaction mixture was filtered through diatomaceous earth and then layered, the aqueous layer was extracted with ethyl acetate (3 x 75 ml). The organic layers were combined and washed with brine (100 ml). Darco KBB (1.24 g) was added to the organic layer, filtered again through diatomaceous earth and dried with anhydrous sodium sulfate (10.0 g). Finally, the solution was concentrated under reduced pressure to afford the target product 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine in 52% yield.

References

[1] European Journal of Medicinal Chemistry, 2012, vol. 52, p. 205 - 212
[2] Patent: WO2007/12953, 2007, A2. Location in patent: Page/Page column 24
[3] Patent: US2010/3250, 2010, A1. Location in patent: Page/Page column 20
[4] Journal of Medicinal Chemistry, 2010, vol. 53, # 8, p. 3169 - 3182
[5] Patent: US2009/54425, 2009, A1. Location in patent: Page/Page column 21

2,4-DICHLORO-7H-PYRROLO2,3-DPYRIMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4-DICHLORO-7H-PYRROLO2,3-DPYRIMIDINE Suppliers

Americas 1 Canada 1 China 485 Europe 1 France 1 Germany 4 India 31 Japan 1 Switzerland 1 United Kingdom 11 United States 47 Global 584

Shanghai Boc Chemical Co.,Ltd

Tel: 021-34975603-808 18721111801
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View Lastest Price from 2,4-DICHLORO-7H-PYRROLO2,3-DPYRIMIDINE manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd

Product: 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine 90213-66-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: Customise
Release date: 2025-11-27

Jinan Finer Chemical Co., Ltd

Product: 2,4-Dichloro-1H-pyrrolo[2,3-d]pyrimidine 90213-66-4
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 99%
Supply Ability: 20mt/year
Release date: 2021-06-18

Shaanxi Xianhe Biotech Co., Ltd

Product: 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine 90213-66-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 1000kg
Release date: 2025-04-18

90213-66-4, 2,4-DICHLORO-7H-PYRROLO2,3-DPYRIMIDINERelated Search:

Acyclovir DEAZAPURINE (3S,4S)-1-Benzyl-N,4-dimethylpiperidin-3-amine 1-Piperidinepropanenitrile, 4-Methyl-3-(Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-ylaMino)-β-oxo- Tofacitinib Related Compound 42 Tofacitinib Related Compound 36 Trifluorothymine 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine 4-Amino-7H-pyrrolo[2,3-d]pyrimidine 2-Amino-4-chloropyrrolo[2,3-d]pyrimidine 2-Thiouracil 2,4-DICHLORO-5H-PYRROLO[3,2-D]PYRIMIDINE 4-Chloro-5-iodo-7H-pyrrol[2,3-d]pyrimidine Pyrrolo[2,3-d]pyrimidin-4-ol N4-Benzoylcytosine 4-CHLORO-7-TOSYL-7H-PYRROLO[2,3-D]PYRIMIDINE 4-Aminopyrazolo[3,4-d]pyrimidine 5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

2,4-DICHLORO-7H-PYRROLO2,3-DPYRIMIDINE

2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine 95%

2,4-dichloro-7H pyrrole [2,3-D] pyrimidine

2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimdine

2,4-DICichloro-7H-pyrilo[2,3-D]pyrimidine

Tofacitinib-8

2,4-Dichloro-7H-pyrrolo-[2,3-D]pyimidine

2,6-Dichloro-7-deazapurine

2,6-dichloro-7-deazapurin

2,4-DICHLORO-7H-PYROLO-[2,3-D]PYRIMIDINE

4,6-DICHLORO PURINE

2,4-Dichloro-1H-pyrrolo[2,3-d]pyrimidine

2,4-Dichloro-7H-pyrrolo[2...

7H-Pyrrolo[2,3-d]pyriMidine, 2,4-dichloro-

2,4-dichloro-7H-pyrrol-(2,3-d)pyriMidine

2,4-Dichloro-7H-pyrrolo[2,3-d]pyriMidine, 98+%

Tofacitinib Intermediate II

2,6-Dichloro-7-deazapurine&gt

oro-7H-pyrroL

o (2,3-d)pyrimidine

2,4-DICHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE 90213-66-4

2,4-Dichloropyrrolo[2,3-d]pyrimidine

Azilsartan medoxomil impurity346

Tofatinib Impurity 7

2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine (Tofacitinib Impurity)

90213-66-4

Heterocycle-Pyrimidine series

Nucleotides and Nucleosides

CHIRAL CHEMICALS

Bases & Related Reagents

Intermediates

Nucleotides