ChemicalBook > CAS DataBase List > Trifluorothymine

Trifluorothymine

Product Name
Trifluorothymine
CAS No.
54-20-6
Chemical Name
Trifluorothymine
Synonyms
5-(TRIFLUOROMETHYL)URACIL;TRIFLUOROMETHYLURACIL;5-(trifluoroMethyl)pyriMidine-2,4-diol;5-(Trifluoromethyl)pyrimidine-2,4(1H,3H)-dione;5-Trifluoromethyl;2,4-DIHYDROXY-5-TRIFLUOROMETHYL-1H-PYRIMIDINE;L 595725-0-1;TRIFLUOROTHYMINE;5-Trifluorothymine;Trifluorothymine 5-
CBNumber
CB8684875
Molecular Formula
C5H3F3N2O2
Formula Weight
180.08
MOL File
54-20-6.mol
More
Less

Trifluorothymine Property

Melting point:
245-246 °C(lit.)
Density 
1.5484 (estimate)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
methanol: soluble50mg/mL, clear
pka
6.63±0.10(Predicted)
form 
powder to crystal
color 
White to Orange to Green
Water Solubility 
INSOLUBLE
BRN 
612694
InChIKey
LMNPKIOZMGYQIU-UHFFFAOYSA-N
CAS DataBase Reference
54-20-6(CAS DataBase Reference)
NIST Chemistry Reference
2,4(1H,3h)-pyrimidinedione, 5-(trifluoromethyl)-(54-20-6)
More
Less

Safety

Hazard Codes 
Xi,T
Risk Statements 
22-36/38-40-36/37/38-25
Safety Statements 
24/25-36-26
RIDADR 
2811
WGK Germany 
3
RTECS 
YR1750000
Hazard Note 
Irritant
HazardClass 
6.1
PackingGroup 
HS Code 
29335990
Toxicity
LD50 intraperitoneal in mouse: 800mg/kg
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
223271
Product name
Trifluorothymine
Purity
97%
Packaging
250mg
Price
$26.6
Updated
2024/03/01
TCI Chemical
Product number
T1622
Product name
5-(Trifluoromethyl)uracil
Purity
>97.0%(HPLC)
Packaging
1g
Price
$74
Updated
2024/03/01
TCI Chemical
Product number
T1622
Product name
5-(Trifluoromethyl)uracil
Purity
>97.0%(HPLC)
Packaging
5g
Price
$213
Updated
2024/03/01
Alfa Aesar
Product number
L16196
Product name
5-(Trifluoromethyl)uracil, 97%
Packaging
250mg
Price
$43.4
Updated
2021/12/16
Alfa Aesar
Product number
L16196
Product name
5-(Trifluoromethyl)uracil, 97%
Packaging
1g
Price
$112
Updated
2021/12/16
More
Less

Trifluorothymine Chemical Properties,Usage,Production

Chemical Properties

White to faintly yellow crystalline powder

Uses

Trifluorothymine is an antitumor and antiviral agent. Trifluorothymine was found in patientsтАЩ urine as a metabolite of Trifluorothymidine as cancer treatment.

Application

Trifluorothymine (5-(Trifluoromethyl)uracil) is an application medicine intermediate widely. It may be used for the synthesis of the cancer therapy drug trifluridine and also can be used for the preparation of the 2, 4-dichloro-5-trifluoromethyluracil.

Synthesis

Uracil and sodium triflate can be used as raw materials to synthesize Trifluorothymine. This reaction uses a mixed solvent of methylene chloride and water as the reaction solvent and tert-butyl hydroperoxide as the catalyst.

Trifluorothymine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Trifluorothymine Suppliers

CHANGZHOU FLUORIDE CHEMICAL CO.,LTD
Tel
15995021858
Fax
0519-85227531
Email
info@fluoridechem.com
Country
China
ProdList
80
Advantage
58
Shanghai Zhuorui Chemical Co.,Ltd.
Tel
021-69180038
Fax
0086-21-39177059
Email
zhuoruichem@163.com
Country
China
ProdList
105
Advantage
58
Shandong Xuande Pharmaceutical Technology Co. LTD
Tel
18866895588
Fax
0531-82777287
Email
dingjiaying@shiningpharm.com
Country
China
ProdList
111
Advantage
55
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696;
Email
info@hanhongsci.com
Country
China
ProdList
42982
Advantage
64
Hangzhou Chemtrue Bio-Tech Co.,Ltd.
Tel
0571-86828652 19967494293
Fax
0571-83522824
Email
sales@chemtrue-bio.com
Country
China
ProdList
314
Advantage
58
Yangzhou modier Electronic Materials Co., Ltd
Tel
0514-82098883; 13761402923
Email
market@modeltemol.com
Country
China
ProdList
870
Advantage
58
Cool Pharm, Ltd
Tel
18019463053
Fax
021-50966098
Email
sales@coolpharm.com
Country
China
ProdList
13017
Advantage
58
Shangfluoro
Tel
021-021-65170832 13331983812
Email
qinba_2@163.com
Country
China
ProdList
301
Advantage
58
Beijing InnoChem Science & Technology Co., Ltd.
Tel
15652467323 15652467323
Email
sales@inno-chem.com.cn
Country
China
ProdList
8293
Advantage
58
SiChuang NanBu Honesty Technology Co., Ltd.
Tel
0838-5675166 15883665058
Fax
0838-5675535
Email
nbcxkj@126.com
Country
China
ProdList
668
Advantage
55
More
Less

View Lastest Price from Trifluorothymine manufacturers

Shanghai Joiny Pharmaceutical Co.,LTD
Product
Trifluorothymine 54-20-6
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000KG
Release date
2023-02-28
Weijer International Trade (Hebei) Co., Ltd
Product
Trifluorothymine 54-20-6
Price
US $1.00/kg
Min. Order
1kg
Purity
>99%
Supply Ability
300000T
Release date
2023-03-09
Hebei Mojin Biotechnology Co., Ltd
Product
Trifluorothymine 54-20-6
Price
US $688.50/KG
Min. Order
25KG
Purity
99.99%
Supply Ability
200ton
Release date
2023-08-15

54-20-6, TrifluorothymineRelated Search:


  • 2,4-DIHYDROXY-5-TRIFLUOROMETHYL-1H-PYRIMIDINE
  • 5-TRIFLUOROMETHYL-1H-PYRIMIDIN-2,4-DIONE
  • 5-(TRIFLUOROMETHYL)URACIL: 98.5%
  • 5-Trifluoromethyl
  • 5-(Trifluoromethyl)pyrimidine-2,4(1H,3H)-dione
  • 5-(Trifluoromethyl)uracil,99%
  • 5-TRIFLUORMETHYL-URACIL
  • 1,3,6-trifluoro-5-Methyl-1,2,3,4-tetrahydropyriMidine-2,4-dione
  • 5-(trifluoroMethyl)pyriMidine-2,4-diol
  • 2,4(1H,3H)-PyriMidinedione,5-(trifluoroMethyl)-
  • 5-(Trifluoromethyl)pyrimidine-2,4(1H,3H)-dione, 2,4-Dioxo-1,2,3,4-tetrahydro-5-(trifluoromethyl)pyrimidine
  • 5-Trifluoromethyluracil≥ 98% (HPLC)
  • TRIFLUOROTHYMINE
  • TRIFLUOROMETHYLURACIL
  • 1,2,3,4-Tetrahydropyrazin-2,4-dione, 5-trifluoromethyl-
  • 3h)-pyrimidinedione,5-(trifluoromethyl)-4(1h
  • 5-(Trifluoromethyl)-2,4(1H,3H)-pyrimidinedione
  • 5-(trifluoromethyl)-uraci
  • L 595725-0-1
  • Uracil, 5-(trifluoromethyl)-
  • 5-(Trifluoromethyl)uracil98%
  • Trifluorothymine###2,4-Dichloro-5-trichloromethylpyrimidine
  • 5-(TRIFLUOROMETHYL)URACIL
  • 5-(trifluoromethyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione
  • TRIFLUOROMETHYLURACIL CRYSTALLINE
  • 5-(Trifluoromethyl)uracil,97%
  • TRIFLUOROTHYMINE(RS20000094)
  • 5-Trifluorothymine
  • Trifluorothymine 5-
  • ifluoromethyl)pyrimidine-2,4(1H,3H)-dione
  • Trifluorothymine-13C4-15N2
  • Trifluorothymine,54-20-6
  • 5-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione (5-(trifluoromethyl)uracil
  • 5-TRIFLUOROMETHYLURACIL Trifluorothymine
  • 54-20-6
  • Pyrimidines
  • Heterocyclic Building Blocks
  • Building Blocks
  • Pyrimidine
  • Pyrimidines
  • Miscellaneous
  • Pyrimidine series
  • Indolines ,Indoles ,Indazoles
  • 54-20-6