Trifluorothymine

Product Name: Trifluorothymine
CAS No.: 54-20-6
Chemical Name: Trifluorothymine
Synonyms: 5-(TRIFLUOROMETHYL)URACIL;TRIFLUOROMETHYLURACIL;5-(trifluoroMethyl)pyriMidine-2,4-diol;5-(Trifluoromethyl)pyrimidine-2,4(1H,3H)-dione;5-Trifluoromethyl;2,4-DIHYDROXY-5-TRIFLUOROMETHYL-1H-PYRIMIDINE;L 595725-0-1;TRIFLUOROTHYMINE;5-Trifluorothymine;Trifluorothymine 5-
CBNumber: CB8684875
Molecular Formula: C5H3F3N2O2
Formula Weight: 180.08
MOL File: 54-20-6.mol

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Trifluorothymine Property

Melting point:: 245-246 °C(lit.)
Density: 1.5484 (estimate)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: methanol: soluble50mg/mL, clear
pka: 6.63±0.10(Predicted)
form: powder to crystal
color: White to Orange to Green
Water Solubility: INSOLUBLE
BRN: 612694
InChIKey: LMNPKIOZMGYQIU-UHFFFAOYSA-N
CAS DataBase Reference: 54-20-6(CAS DataBase Reference)
NIST Chemistry Reference: 2,4(1H,3h)-pyrimidinedione, 5-(trifluoromethyl)-(54-20-6)

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Safety

Hazard Codes: Xi,T
Risk Statements: 22-36/38-40-36/37/38-25
Safety Statements: 24/25-36-26
RIDADR: 2811
WGK Germany: 3
RTECS: YR1750000
Hazard Note: Irritant
HazardClass: 6.1
PackingGroup: Ⅲ
HS Code: 29335990
Toxicity: LD50 intraperitoneal in mouse: 800mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 223271
Product name: Trifluorothymine
Purity: 97%
Packaging: 250mg
Price: $26.6
Updated: 2024/03/01

TCI Chemical

Product number: T1622
Product name: 5-(Trifluoromethyl)uracil
Purity: >97.0%(HPLC)
Packaging: 1g
Price: $74
Updated: 2024/03/01

TCI Chemical

Product number: T1622
Product name: 5-(Trifluoromethyl)uracil
Purity: >97.0%(HPLC)
Packaging: 5g
Price: $213
Updated: 2024/03/01

Alfa Aesar

Product number: L16196
Product name: 5-(Trifluoromethyl)uracil, 97%
Packaging: 250mg
Price: $43.4
Updated: 2021/12/16

Alfa Aesar

Product number: L16196
Product name: 5-(Trifluoromethyl)uracil, 97%
Packaging: 1g
Price: $112
Updated: 2021/12/16

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Trifluorothymine Chemical Properties,Usage,Production

Chemical Properties

White to faintly yellow crystalline powder

Uses

Trifluorothymine is an antitumor and antiviral agent. Trifluorothymine was found in patientsтАЩ urine as a metabolite of Trifluorothymidine as cancer treatment.

Application

Trifluorothymine (5-(Trifluoromethyl)uracil) is an application medicine intermediate widely. It may be used for the synthesis of the cancer therapy drug trifluridine and also can be used for the preparation of the 2, 4-dichloro-5-trifluoromethyluracil.

Synthesis

Uracil and sodium triflate can be used as raw materials to synthesize Trifluorothymine. This reaction uses a mixed solvent of methylene chloride and water as the reaction solvent and tert-butyl hydroperoxide as the catalyst.

Trifluorothymine Preparation Products And Raw materials

Raw materials

Preparation Products

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Trifluorothymine Suppliers

Belgium 2 Canada 1 China 284 France 2 Germany 11 India 19 Italy 1 Japan 5 Slovakia 1 Switzerland 2 United Kingdom 17 United States 45 Global 390

Acros Organics (Part of Thermo Fisher Scientific )

Tel: --
Fax: --
Email: fo@acros.com
Country: Belgium
ProdList: 3824
Advantage: 58

Acros Organics

Tel: --
Fax: --
Email: info@acros.com
Country: Belgium
ProdList: 6772
Advantage: 81

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View Lastest Price from Trifluorothymine manufacturers

Shanghai Joiny Pharmaceutical Co.,LTD

Product: Trifluorothymine 54-20-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000KG
Release date: 2023-02-28

Hebei Weibang Biotechnology Co., Ltd

Product: Trifluorothymine 54-20-6
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2023-03-10

Henan Fengda Chemical Co., Ltd

Product: Trifluorothymine 54-20-6
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-09

54-20-6, TrifluorothymineRelated Search:

(Trifluoromethyl)trimethylsilane 3-(Trifluoromethyl)benzaldehyde 3-（trifluoromethyl) Cinnamaldehyde Trifluoromethanesulfonic acid Trifluoromethanesulfonic anhydride 3-(Trifluoromethyl)benzoic acid 2-Methylbenzotrifluoride [2-13C,15N2]-Trifluorothymine Trifluridine Impurity Trifluridine 6-(TRIFLUOROMETHYL)URACIL Thymine Uracil 5-(TRIFLUOROMETHYL)-URIDINE 1-(2-HYDROXY-ETHOXYMETHYL)-5-TRIFLUOROMETHYL-1H-PYRIMIDINE-2,4-DIONE 3'-O-benzyl-2'-deoxy-5-trifluoromethyluridine Trifluoromethyl Trifluorothymine

2,4-DIHYDROXY-5-TRIFLUOROMETHYL-1H-PYRIMIDINE

5-TRIFLUOROMETHYL-1H-PYRIMIDIN-2,4-DIONE

5-(TRIFLUOROMETHYL)URACIL: 98.5%

5-Trifluoromethyl

5-(Trifluoromethyl)pyrimidine-2,4(1H,3H)-dione

5-(Trifluoromethyl)uracil,99%

5-TRIFLUORMETHYL-URACIL

1,3,6-trifluoro-5-Methyl-1,2,3,4-tetrahydropyriMidine-2,4-dione

5-(trifluoroMethyl)pyriMidine-2,4-diol

2,4(1H,3H)-PyriMidinedione,5-(trifluoroMethyl)-

5-(Trifluoromethyl)pyrimidine-2,4(1H,3H)-dione, 2,4-Dioxo-1,2,3,4-tetrahydro-5-(trifluoromethyl)pyrimidine

5-Trifluoromethyluracil≥ 98% (HPLC)

TRIFLUOROTHYMINE

TRIFLUOROMETHYLURACIL

1,2,3,4-Tetrahydropyrazin-2,4-dione, 5-trifluoromethyl-

3h)-pyrimidinedione,5-(trifluoromethyl)-4(1h

5-(Trifluoromethyl)-2,4(1H,3H)-pyrimidinedione

5-(trifluoromethyl)-uraci

L 595725-0-1

Uracil, 5-(trifluoromethyl)-

5-(Trifluoromethyl)uracil98%

Trifluorothymine###2,4-Dichloro-5-trichloromethylpyrimidine

5-(TRIFLUOROMETHYL)URACIL

5-(trifluoromethyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione

TRIFLUOROMETHYLURACIL CRYSTALLINE

5-(Trifluoromethyl)uracil,97%

TRIFLUOROTHYMINE(RS20000094)

5-Trifluorothymine

Trifluorothymine 5-

ifluoromethyl)pyrimidine-2,4(1H,3H)-dione

Trifluorothymine-13C4-15N2

Trifluorothymine,54-20-6

5-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione (5-(trifluoromethyl)uracil

5-TRIFLUOROMETHYLURACIL Trifluorothymine

54-20-6

Pyrimidines

Heterocyclic Building Blocks

Building Blocks

Pyrimidine

Pyrimidines

Miscellaneous

Pyrimidine series

Indolines ,Indoles ,Indazoles

54-20-6