ChemicalBook > CAS DataBase List > 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine

3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Product Name
3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS No.
151266-23-8
Chemical Name
3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Synonyms
4-Amino-3-iodopyrazolo[3,4-d]pyrimidine;IbrutinibIntermediate6;7-Iodo-7-deaza-8-aza-adenine;4-AMINO-3-IODO-1H-PYRAZOLO[3;4-AMino-3-iodopyrazolo[3,4-d]pyridine;3-iodo-4-Aminopyrazolo[3,4-d]pyridine;3-iodopyrazolo[3,4-d]pyriMidin-4-aMine;3-iodo-4-AMino-1H-pyrazolo[3,4-d]pyridine;4-Amino-3-iodo-1H-pyrazolo[3,4-D]pyridine;3-iodo-2H-pyrazolo[3,4-d]pyrimidin-4-amine
CBNumber
CB8144555
Molecular Formula
C5H4IN5
Formula Weight
261.02
MOL File
151266-23-8.mol
More
Less

3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine Property

Boiling point:
312.3±52.0 °C(Predicted)
Density 
2.92±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
powder to crystal
pka
10.50±0.20(Predicted)
color 
White to Light yellow to Light orange
Sensitive 
Light Sensitive
λmax
282nm(lit.)
InChI
InChI=1S/C5H4IN5/c6-3-2-4(7)8-1-9-5(2)11-10-3/h1H,(H3,7,8,9,10,11)
InChIKey
HQAIUXZORKJOJY-UHFFFAOYSA-N
SMILES
C1=NC(N)=C2C(I)=NNC2=N1
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
36/37/38-22
Safety Statements 
26-36/37/39-37
TSCA 
N
HS Code 
29335990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More
Less

N-Bromosuccinimide Price

TCI Chemical
Product number
I0941
Product name
3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$61
Updated
2024/03/01
TCI Chemical
Product number
I0941
Product name
3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$300
Updated
2024/03/01
Alfa Aesar
Product number
H52572
Product name
4-Amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine, 97%
Packaging
250mg
Price
$144
Updated
2021/12/16
TRC
Product number
I736005
Product name
3-Iodo-3H-pyrazolo[3,4-d]pyrimidin-4-amine
Packaging
1g
Price
$105
Updated
2021/12/16
TRC
Product number
I736005
Product name
3-Iodo-3H-pyrazolo[3,4-d]pyrimidin-4-amine
Packaging
25g
Price
$1765
Updated
2021/12/16
More
Less

3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine Chemical Properties,Usage,Production

Uses

3-Iodo-3H-pyrazolo[3,4-d]pyrimidin-4-amine acts as a reagent in the discovery and preparation of CHMFL-FLT3-122 as potent and orally available FLT3 kinase inhibitor for FLT3-ITD positive acute myeloid leukemia. Development and preparation of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes.

Synthesis

A solution of 3H-pyrazolo[3,4-d]pyrimidin-4-amine (10 g, 0.074 mol) and n-iodo-succinamide (25 g, 0.111 mol) in DMF (80 mL) was heated to 80° C. overnight under an argon atmosphere. The resulting solid was filtered and rinsed with cold EtOH. The product was dried in vacuo overnight to yield 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine (24 g, 100 per cent yield).

3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine Suppliers

Varnor Chemical Co., Ltd.
Tel
0796-8330061 18779971813
Fax
0086-796-8330061
Email
sales@varnorchem.com
Country
China
ProdList
21
Advantage
55
Sichuan Lancent Medical Devices Co., Ltd.
Tel
18111675298
Fax
-
Email
stochem@aliyun.com
Country
China
ProdList
204
Advantage
58
Beijing Xinze Pharmaceutical Technology Co., Ltd.
Tel
010-61393740 13121768631
Email
weihong_1979@163.com
Country
China
ProdList
49
Advantage
58
LinkChem Co.,Ltd.
Tel
021-021-58950110 13124863828
Fax
021-20922272
Email
sales@linkchem.cn
Country
China
ProdList
2981
Advantage
58
Taizhou Creating Bio-pharm Co.,Ltd.
Tel
+86-0576-88827176 +86-18906581668
Email
post@creatingchemical.com
Country
China
ProdList
229
Advantage
58
Chengdu Kelai Hyde Pharmaceutical Technology Co., Ltd
Tel
18482172240 18482172240
Email
609320203@qq.com
Country
China
ProdList
68
Advantage
58
Jinan Dexinjia Bio&Tech Co., Ltd
Tel
0531-82371986 15064117275
Fax
0531-82375893
Email
daisy@jndxj.com
Country
China
ProdList
1321
Advantage
58
SiChuang NanBu Honesty Technology Co., Ltd.
Tel
0838-5675166 15883665058
Fax
0838-5675535
Email
nbcxkj@126.com
Country
China
ProdList
668
Advantage
55
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
More
Less

View Lastest Price from 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine manufacturers

Nanjing Fred Technology Co., Ltd
Product
4-Amino-3-Iodo-1H-Pyrazolo[3,4-D]Pyrimidine 151266-23-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2023-12-28
Henan Fengda Chemical Co., Ltd
Product
3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine 151266-23-8
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
98%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-09
Dideu Industries Group Limited
Product
4-AMINO-3-IODO-1H-PYRAZOLO[3,4-D]PYRIMIDINE 151266-23-8
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-12-06

151266-23-8, 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine Related Search:


  • 3-iodo-2H-pyrazolo[3,4-d]pyrimidin-4-amine
  • 3-IODO-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE
  • 4-AMINO-3-IODO-1H-PYRAZOLO[3,4-D]PYRIMIDINE
  • 4-Amino-3-iodopyrazolo[3,4-d]pyrimidine
  • 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-iodo-
  • 4-Amino-3-iodo-1H-pyrazolo[3,4-D]pyridine
  • 3-iodo-4-AMino-1H-pyrazolo[3,4-d]pyridine
  • 7-Iodo-7-deaza-8-aza-adenine
  • 3-iodopyrazolo[3,4-d]pyriMidin-4-aMine
  • 4-AMino-3-iodopyrazolo[3,4-d]pyridine
  • 3-iodo-4-aMino-1H-pyrazolo[3,4-d]pyriMidine
  • 3-iodo-4-Aminopyrazolo[3,4-d]pyridine
  • 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine &gt
  • 4-AMINO-3-IODO-1H-PYRAZOLO[3,4-D]PYRIMIDINE ISO 9001:2015 REACH
  • 4-AMINO-3-IODO-1H-PYRAZOLO[3
  • TIANFU-CHEM - 4-AMINO-3-IODO-1H-PYRAZOLO[3,4-D]PYRIMIDINE
  • 3-Iodo-4-amino-1H-pyrazolo[3,4-d]pyrimidine, 7-Iodo-7-deaza-8-azaadenine
  • 3-iodo-5H-pyrazolo[3,4-d]pyrimidin-4-amine
  • 4-AMINO-3-iodo-1H-Pyrazolo[3,4-D]Pyrimidin
  • 3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine
  • IbrutinibIntermediate6
  • 151266-23-8
  • Heterocycle-Pyridine series
  • pharmacetical