3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine
- Product Name
- 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine
- CAS No.
- 151266-23-8
- Chemical Name
- 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine
- Synonyms
- 4-Amino-3-iodopyrazolo[3,4-d]pyrimidine;IbrutinibIntermediate6;7-Iodo-7-deaza-8-aza-adenine;4-AMINO-3-IODO-1H-PYRAZOLO[3;4-AMino-3-iodopyrazolo[3,4-d]pyridine;3-iodo-4-Aminopyrazolo[3,4-d]pyridine;3-iodopyrazolo[3,4-d]pyriMidin-4-aMine;3-iodo-4-AMino-1H-pyrazolo[3,4-d]pyridine;4-Amino-3-iodo-1H-pyrazolo[3,4-D]pyridine;3-iodo-2H-pyrazolo[3,4-d]pyrimidin-4-amine
- CBNumber
- CB8144555
- Molecular Formula
- C5H4IN5
- Formula Weight
- 261.02
- MOL File
- 151266-23-8.mol
3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine Property
- Boiling point:
- 312.3±52.0 °C(Predicted)
- Density
- 2.92±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 10.50±0.20(Predicted)
- color
- White to Light yellow to Light orange
- Sensitive
- Light Sensitive
- λmax
- 282nm(lit.)
- InChI
- InChI=1S/C5H4IN5/c6-3-2-4(7)8-1-9-5(2)11-10-3/h1H,(H3,7,8,9,10,11)
- InChIKey
- HQAIUXZORKJOJY-UHFFFAOYSA-N
- SMILES
- C1=NC(N)=C2C(I)=NNC2=N1
Safety
- Hazard Codes
- Xn
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-36/37/39-37
- TSCA
- N
- HS Code
- 29335990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- I0941
- Product name
- 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $61
- Updated
- 2024/03/01
- Product number
- I0941
- Product name
- 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $300
- Updated
- 2024/03/01
- Product number
- H52572
- Product name
- 4-Amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine, 97%
- Packaging
- 250mg
- Price
- $144
- Updated
- 2021/12/16
- Product number
- I736005
- Product name
- 3-Iodo-3H-pyrazolo[3,4-d]pyrimidin-4-amine
- Packaging
- 1g
- Price
- $105
- Updated
- 2021/12/16
- Product number
- I736005
- Product name
- 3-Iodo-3H-pyrazolo[3,4-d]pyrimidin-4-amine
- Packaging
- 25g
- Price
- $1765
- Updated
- 2021/12/16
3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine Chemical Properties,Usage,Production
Uses
3-Iodo-3H-pyrazolo[3,4-d]pyrimidin-4-amine acts as a reagent in the discovery and preparation of CHMFL-FLT3-122 as potent and orally available FLT3 kinase inhibitor for FLT3-ITD positive acute myeloid leukemia. Development and preparation of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes.
Synthesis
A solution of 3H-pyrazolo[3,4-d]pyrimidin-4-amine (10 g, 0.074 mol) and n-iodo-succinamide (25 g, 0.111 mol) in DMF (80 mL) was heated to 80° C. overnight under an argon atmosphere. The resulting solid was filtered and rinsed with cold EtOH. The product was dried in vacuo overnight to yield 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine (24 g, 100 per cent yield).
3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine manufacturers
- Product
- 4-Amino-3-Iodo-1H-Pyrazolo[3,4-D]Pyrimidine 151266-23-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1 ton
- Release date
- 2023-12-28
- Product
- 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine 151266-23-8
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-09
- Product
- 4-AMINO-3-IODO-1H-PYRAZOLO[3,4-D]PYRIMIDINE 151266-23-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-06