ChemicalBook > CAS DataBase List > 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine

4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine

Product Name: 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine
CAS No.: 479633-63-1
Chemical Name: 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine
Synonyms: Tofacitinib Impurity 20;Tofacitinib-9;Tofacitinib imurity;Tofatinib Impurity 1;Tofatinib Impurity P;Tofacitinib Impurity R;Tofacitinib Impurity 53;Tofacitinib Impurity 163;4-Chloro-7-tosyl-7H-pyrro...;4-Chloro-7-tosyl-7H-pyrrolo[2
CBNumber: CB32452480
Molecular Formula: C13H10ClN3O2S
Formula Weight: 307.76
MOL File: 479633-63-1.mol

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4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine Property

Melting point:: 145.0 to 149.0 °C
Boiling point:: 505.3±60.0 °C(Predicted)
Density: 1.49
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), DMSO (Slightly)
form: powder to crystal
pka: 1.73±0.30(Predicted)
color: White to Orange to Green
InChI: InChI=1S/C13H10ClN3O2S/c1-9-2-4-10(5-3-9)20(18,19)17-7-6-11-12(14)15-8-16-13(11)17/h2-8H,1H3
InChIKey: BTOJSYRZQZOMOK-UHFFFAOYSA-N
SMILES: C1=NC(Cl)=C2C=CN(S(C3=CC=C(C)C=C3)(=O)=O)C2=N1

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Safety

Hazard Codes: Xn
Risk Statements: 22
HazardClass: IRRITANT
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: ADE000077
Product name: 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine
Purity: Aldrich
Packaging: 1g
Price: $761
Updated: 2023/06/20

TCI Chemical

Product number: C3036
Product name: 4-Chloro-7-(p-toluenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidine
Purity: >96.0%(HPLC)(N)
Packaging: 1g
Price: $74
Updated: 2025/07/31

TCI Chemical

Product number: C3036
Product name: 4-Chloro-7-(p-toluenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidine
Purity: >96.0%(HPLC)(N)
Packaging: 5g
Price: $296
Updated: 2023/06/20

AK Scientific

Product number: AMTH013
Product name: 4-Chloro-7-(toluene-4-sulfonyl)-7H-pyrrolo[2,3-d]pyrimidine
Packaging: 1g
Price: $10
Updated: 2021/12/16

Matrix Scientific

Product number: 058631
Product name: 4-Chloro-7-[(4-methylbenzene)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine
Purity: >95%
Packaging: 1g
Price: $10
Updated: 2021/12/16

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4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine Chemical Properties,Usage,Production

Uses

4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine is a reagent in the synthesis of (+)-tofacitinib, a selective Janus kinase 3 inhibitor (JAK3) and an immunosuppressant drug.

Synthesis

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine (2kg, 12.96mol) and dichloromethane (40L) were added to the reaction flask at room temperature, stirred and dissolved. Triethylamine (3.88 kg, 38.4 mol) and 4-dimethylamino pyridine (157.6 g, 1.28 mol) were added in that order, and after stirring and dissolved, p-toluenesulfonyl chloride (2.6 kg, 13.6 mol) was added dropwise at 0 °C. The chloromethane (30 L) solution was added dropwise, and the mixture was stirred at room temperature for 30 min. After the TLC was applied, the mixture was washed with water (16L×3). 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine (3.9 kg, yield 97.7%) was obtained after drying under reduced pressure.

References

[1] Patent: WO2007/117494, 2007, A1. Location in patent: Page/Page column 61-62

4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine manufacturers

Jinan Ruitong Biotech Co., Ltd.

Product: 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine 479633-63-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1
Release date: 2025-08-28

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine 479633-63-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-01-18

Henan Aochuang Chemical Co.,Ltd.

Product: 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine 479633-63-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-08

479633-63-1, 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidineRelated Search:

N-Methyl-N-((3S,4S)-4-Methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyriMidin-4-aMine 7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]-7-[(4-Met hylphenyl)sulfonyl]- (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride DEAZAPURINE 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine Trifluorothymine 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine 2,4-DICHLORO-7H-PYRROLO2,3-DPYRIMIDINE 4-Amino-7H-pyrrolo[2,3-d]pyrimidine 2-Amino-4-chloropyrrolo[2,3-d]pyrimidine 2-Thiouracil 2,4-DICHLORO-5H-PYRROLO[3,2-D]PYRIMIDINE 4-Chloro-5-iodo-7H-pyrrol[2,3-d]pyrimidine Pyrrolo[2,3-d]pyrimidin-4-ol N4-Benzoylcytosine 4-Aminopyrazolo[3,4-d]pyrimidine 5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine Tofacitinib Impurity T

Tofacitinib Impurity R

4-Chloro-7-(p-tolylsulfonyl)pyrrolo[2,3-d]pyrimidine

4-CHLORO-7-[(4-METHYLPHENYL)SULFONYL]-7H-PYRROLO[2,3-D]PYRIMIDINE

4-CHLORO-7-TOSYL-7H-PYRROLO[2,3-D]PYRIMIDINE

4-Chloro-7-tosyl-7H-pyrro...

4-Chloro-7-[(4-methylbenzene)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine

4-Chloro-7-p-toluenesulphonyl-7H-pyrrolo[2,3-d]pyrimidine

7H-Pyrrolo[2,3-D]pyriMidine,4-chloro-7-[(4-Methylphenyl)sulfonyl]-

4-Chloro-7-tosyl-7H-pyrrolo[2

4-chloro-7-(4-methylphenyl)sulfonylpyrrolo[2,3-d]pyrimidine

Tofacitinib-9

4-Chloro-7-[(4-methylbenzene)sulfonyl]pyrrolo[2,3-d]pyrimidine

Tofacitinib imurity

3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-2-yl) amino)piperidin-1-yl)-3-oxopropanenitrile

4-Chloro-7-(p-toluenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidine

4-Chloro-7-(toluene-4-sulfonyl)-7H-pyrrolo[2,3-d]pyrimidine

Tofacitinib Impurity 53

Tofacitinib Impurity 20

4-Chloro-7-(p-toluenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidine &gt

4-Chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrim...

Azilsartan medoxomil impurity345

Tofatinib Impurity 1

Tofatinib Impurity P

Tofacitinib Impurity 163

4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine 98%

4-chlorine-7-Tosyl-7H-Pyrrole[2,3-D]Pyrimidine

4-Chloro-7-(p-toluenesulfonyl)-7H-pyrrolo

479633-63-1

Heterocycle-Pyrimidine series

ADVANCED INT.