7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]-7-[(4-Met hylphenyl)sulfonyl]-

Product Name: 7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]-7-[(4-Met hylphenyl)sulfonyl]-
CAS No.: 923036-30-0
Chemical Name: 7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]-7-[(4-Met hylphenyl)sulfonyl]-
Synonyms: Tofacitinib-13;Tofatinib Impurity 4;Tofacitinib Impurity 160;Azilsartan medoxomil impurity341;7H-Pyrrolo[2,3-d]pyrimidin-4-amine, N-methyl-N-[(3R,4R)-4-me...;N-Des(-3'-oxopropanenitrile)-N-(methyl)benzene Tofacitinib N-Hydrosulfonylmethylbenzene;Tofacitinib impurity 9/N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine;N-((3R,4R)-1-Benzyl-4-methylpiperidin-3-yl)-N-methyl-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (Tofacitinib Impurity);N-Methyl-N-[(3R,4R)-4-methyl-1-(phenylmethyl)-3-piperidinyl]-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine;N-methyl-N - ((3R, 4R) -4-methyl-1-benzyl-3-piperidinyl) -7- ((4-methylphenyl) sulfonyl) 7H-pyrrolo [2,3-D] pyrimidin-4-amine
CBNumber: CB52655584
Molecular Formula: C27H31N5O2S
Formula Weight: 489.63
MOL File: 923036-30-0.mol

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7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]-7-[(4-Met hylphenyl)sulfonyl]- Property

Melting point:: 180-183℃
Boiling point:: 655.2±65.0 °C(Predicted)
Density: 1.27±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 9.02±0.10(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-M2654
Product name: N-((3R,4R)-1-Benzyl-4-methylpiperidin-3-yl)-N-methyl-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Packaging: 1g
Price: $82
Updated: 2021/12/16

ChemScene

Product number: CS-M2654
Product name: N-((3R,4R)-1-Benzyl-4-methylpiperidin-3-yl)-N-methyl-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Packaging: 5g
Price: $285
Updated: 2021/12/16

Ambeed

Product number: A219306
Product name: N-((3R,4R)-1-Benzyl-4-methylpiperidin-3-yl)-N-methyl-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Purity: 97%
Packaging: 5g
Price: $352
Updated: 2021/12/16

Crysdot

Product number: CD11013069
Product name: N-((3R,4R)-1-Benzyl-4-methylpiperidin-3-yl)-N-methyl-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Purity: 97%
Packaging: 1g
Price: $574
Updated: 2021/12/16

Ambeed

Product number: A219306
Product name: N-((3R,4R)-1-Benzyl-4-methylpiperidin-3-yl)-N-methyl-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Purity: 97%
Packaging: 250mg
Price: $37
Updated: 2021/12/16

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7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]-7-[(4-Met hylphenyl)sulfonyl]- Chemical Properties,Usage,Production

Uses

A useful intermediate for the formal asymmetric synthesis of (+)?-?Tofacitinib. An impurity of Tofacitinib(C781351).

Synthesis

477600-70-7

479633-63-1

923036-30-0

(3R,4R)-1-benzyl-4-methyl-3-methylamino-piperidine (4.3 g, 19.7 mmol, 1.0 eq.) was dissolved in 180 mL of water, followed by the addition of 4-chloro-7-toluenesulfonyl-7H-pyrrolo[2,3-D]pyrimidine (12.3 g, 39.2 mmol, 2.0 eq.) and potassium carbonate (16.6 g, 119 mmol. 6.0 eq.). The reaction mixture was stirred at 100 °C for 16 h and then cooled to room temperature. After completion of the reaction, the reaction was extracted three times with ethyl acetate (500 mL), the organic phases were combined and washed sequentially with water and brine. The organic layer was dried with anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The crude product was purified by column chromatography (eluent: ethyl acetate/petroleum ether=1:1) to afford N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7-toluenesulfonyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (8.6 g, 90% yield) as a pale yellow solid.

References

[1] Patent: CN103896946, 2018, B. Location in patent: Paragraph 0084; 0085; 0086
[2] Journal of Medicinal Chemistry, 2008, vol. 51, # 24, p. 8012 - 8018

7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]-7-[(4-Met hylphenyl)sulfonyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]-7-[(4-Met hylphenyl)sulfonyl]- Suppliers

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Shaanxi Xianhe Biotech Co., Ltd

Product: 7H-Pyrrolo[2,3-d]pyrimidin-4-amine,N-methyl-N-[(3R,4R)-4-methyl-1-(phenylmethyl)-3-piperidinyl]-7-[(4-methylphenyl)sulfonyl]- 923036-30-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 1000kg
Release date: 2025-04-17

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Product: Tofacitinib Impurity 4 923036-30-0
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Product: 7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]-7-[(4-Met hylphenyl)sulfonyl]- 923036-30-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500KG
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923036-30-0, 7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]-7-[(4-Met hylphenyl)sulfonyl]-Related Search:

4-(Hydroxyamino)-4-oxobutanoic acid 3-Amino-4-methylpyridine N-((3S,4S)-1-benzyl-4-Methylpiperidin-3-yl)-N-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-aMine Methyl (1-benzyl-4-Methylpiperidin-3-yl)carbaMate 13-Deoxyepirubicin 3-((3R,4S)-4-Methyl-3-(Methyl(7H-pyrrolo[2,3-d]pyriMidin-4-yl)aMino)piperidin-1-yl)-3-oxopropanenitrile 3-METHOXYCARBONYLAMINO-4-METHYLPYRIDINE 1-[2-(2-methoxyphenoxy)ethylamino]-3-(9-methylcarbazol-4-yl)oxypropan-2-ol:hydrochloride Methyl (4-Methylpiperidin-3-yl)carbaMate 3-((3S,4R)-4-Methyl-3-(Methyl(7H-pyrrolo[2,3-d]pyriMidin-4-yl)aMino)piperidin-1-yl)-3-oxopropanenitrile 3-PiperidinaMine, 1-acetyl-N,4-diMethyl-N-1H-pyrrolo[2,3-d]pyriMidin-4-yl-, (3R,4R)- (9CI) 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine 2,4-DICHLORO-7H-PYRROLO2,3-DPYRIMIDINE 3-bis(4-Methylbenzoyloxy)succinate) 4-CHLORO-7-TOSYL-7H-PYRROLO[2,3-D]PYRIMIDINE

N-Methyl-N-[(3R,4R)-4-methyl-1-(phenylmethyl)-3-piperidinyl]-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]-7-[(4-Met hylphenyl)sulfonyl]-

Tofacitinib-13

Tofacitinib impurity 9/N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

N-Des(-3'-oxopropanenitrile)-N-(methyl)benzene Tofacitinib N-Hydrosulfonylmethylbenzene

7H-Pyrrolo[2,3-d]pyrimidin-4-amine, N-methyl-N-[(3R,4R)-4-me...

Azilsartan medoxomil impurity341

Tofatinib Impurity 4

N-((3R,4R)-1-Benzyl-4-methylpiperidin-3-yl)-N-methyl-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (Tofacitinib Impurity)

N-methyl-N - ((3R, 4R) -4-methyl-1-benzyl-3-piperidinyl) -7- ((4-methylphenyl) sulfonyl) 7H-pyrrolo [2,3-D] pyrimidin-4-amine

Tofacitinib Impurity 160

(Z)-3-amino-5-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-2-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carbonyl)-5-oxopent-2-enenitrile

923036-30-0