ChemicalBook > CAS DataBase List > (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride

(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride

Product Name
(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride
CAS No.
1062580-52-2
Chemical Name
(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride
Synonyms
(3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride;TOF30;Tofacitinib-1;Tofatinib Impurity 5;Tofacitinib interMediate A;Tofacitinib intermediate 3;piperidin-3-amine dihydrochL;Tofacitinib Impurity 123 DiHCl;Azilsartan medoxomil impurity351;Tofacitinib Impurity 5 Dihydrochloride
CBNumber
CB21011155
Molecular Formula
C14H23ClN2
Formula Weight
254.8
MOL File
Mol file
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(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Property

Melting point:
249～251℃
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Aqueous Acid (Slightly), DMSO (Slightly, Heated, Sonicated), Methanol (Slightly)
form 
Solid
color 
White to Off-White
InChI
InChI=1/C14H22N2.ClH/c1-12-8-9-16(11-14(12)15-2)10-13-6-4-3-5-7-13;/h3-7,12,14-15H,8-11H2,1-2H3;1H/t12-,14+;/s3
InChIKey
FVRZQLQXDPJADE-WLZBWWFYNA-N
SMILES
C(C1C=CC=CC=1)N1CC[C@@H](C)[C@@H](NC)C1.Cl |&1:10,12,r|
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Safety

HazardClass 
IRRITANT
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
D480190
Product name
(3R,​4R)​-N,​4-​Dimethyl-​1-​(phenylmethyl)​-3-​piperidinamineDihydrochloride
Packaging
10g
Price
$235
Updated
2021/12/16
AK Scientific
Product number
1409AA
Product name
(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-aminedihydrochloride
Packaging
1g
Price
$72
Updated
2021/12/16
Synthonix
Product number
P15037
Product name
3-Piperidinamine,N,4-dimethyl-1-(phenylmethyl)-,hydrochloride(1:2),(3R,4R)-
Purity
95+%
Packaging
10g
Price
$80
Updated
2021/12/16
Apolloscientific
Product number
OR54340
Product name
cis-1-Benzyl-4-methyl-3-(methylamino)piperidine dihydrochloride
Purity
95+%
Packaging
10g
Price
$149
Updated
2021/12/16
SynQuest Laboratories
Product number
3H31-5-2Q
Product name
(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-aminedihydrochloride
Purity
97.0%
Packaging
250mg
Price
$190
Updated
2021/12/16
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(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Chemical Properties,Usage,Production

Uses

(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes.

Uses

(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride is a related compound of Tofacitinib (T528000). (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride can be used to prepare janus kinase 1 selective inhibitor.

Application

(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride is an organic synthesis intermediate and a pharmaceutical intermediate. In laboratory research and in chemical and pharmaceutical development, it is primarily used as an intermediate for the active pharmaceutical ingredient tofacitinib. Tofacitinib is used to treat adult patients with moderate to severe rheumatoid arthritis who have an inadequate response to or are intolerant of methotrexate.

Synthesis


TiCl4(0.2g, 1mmol) and NEt3(0.15 g, 1.5 mmol) were added to toluene, and then add 1-benzyl-4-methyl-3-ketone piperidine (20.3 g, 100 mmol) at 35 ℃. The methylamine solution is added to the reaction solution (9.32 g, 120 mmol) and reaction for 4 h, followed by adding NaBH (OAC) 3 (0.32 g, 1.5 mmol) and glacial acetic acid 2 ml. After the reaction is complete, add saturated salt water to wash the reaction mixture. (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride was obtained after further purification.

(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Suppliers

China 336 India 8 United Kingdom 3 United States 15 Global 362
Shanghai Boc Chemical Co.,Ltd
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021-34975603-808 18721111801
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+86-21-34975602-805
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sales@bocpharma.com
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China
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View Lastest Price from (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride manufacturers

.GZ HONESTCHEM CO.,LTD
Product
(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride 1062580-52-2
Price
US $1.00/g
Min. Order
300g
Purity
99.8%
Supply Ability
20 TONS
Release date
2025-11-05
Shaanxi Xianhe Biotech Co., Ltd
Product
(3R,4R)-1-Benzyl-N,4-diMethylpiperidin-3-Amine dihydrochloride 1062580-52-2
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
1000kg
Release date
2025-04-17
Shanghai Joiny Pharmaceutical Co.,LTD
Product
(3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride 1062580-52-2
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500kg
Release date
2022-09-23

1062580-52-2, (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochlorideRelated Search:

(1-Benzyl-4-Methyl-1,2,5,6-tetrahydropyridin-3-yl)carbaMic acid Methyl ester Methyl (1-benzyl-4-Methylpiperidin-3-yl)carbaMate 13-Deoxyepirubicin 3-((3R,4S)-4-Methyl-3-(Methyl(7H-pyrrolo[2,3-d]pyriMidin-4-yl)aMino)piperidin-1-yl)-3-oxopropanenitrile 3-METHOXYCARBONYLAMINO-4-METHYLPYRIDINE 1-[2-(2-methoxyphenoxy)ethylamino]-3-(9-methylcarbazol-4-yl)oxypropan-2-ol:hydrochloride Methyl (4-Methylpiperidin-3-yl)carbaMate 3-((3S,4R)-4-Methyl-3-(Methyl(7H-pyrrolo[2,3-d]pyriMidin-4-yl)aMino)piperidin-1-yl)-3-oxopropanenitrile 3-PiperidinaMine, 1-acetyl-N,4-diMethyl-N-1H-pyrrolo[2,3-d]pyriMidin-4-yl-, (3R,4R)- (9CI) 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine 2,4-DICHLORO-7H-PYRROLO2,3-DPYRIMIDINE 7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]-7-[(4-Met hylphenyl)sulfonyl]- 4-CHLORO-7-TOSYL-7H-PYRROLO[2,3-D]PYRIMIDINE Tofacitinib citrate 3-bis(4-Methylbenzoyloxy)succinate)

  • CIS-N-BENZYL-3-METHYLAMINO-4-METHYL-PIPERIDINE BIS-(HYDROCHLORIDE)
  • cis-1-Benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride
  • cis-1-Benzyl-4-methyl-3-(methylamino)piperidine dihydrochloride 95+%
  • cis-1-Benzyl-N3,4-dimethylpiperidin-3-amine dihydrochloride
  • (3R,4R)-1-BENZYL-N,4-DIMETHYLPIPERIDIN-3-AMINE DIHYDROCHLORIDE
  • (3R,4R)-1-benzyl-N,4-diMethylpiperidin-3-aMine BIS-(HYDROCHLORIDE)
  • (3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride
  • 3-PiperidinaMine, N,4-diMethyl-1-(phenylMethyl)-, hydrochloride (1:2), (3R,4R)-
  • (3R,4R)-N,4-DiMethyl-1-(phenylMethyl)-3-piperidi
  • (3R,4R)- Cis-1-benzyl-4-Methyl-3-(MethylaMino)piperidine
  • Tofacitinib interMediate A
  • (3R,4R)- cis-1-Benzyl-4-Methyl-3-(MethylaMino)piperidine dihydrochloride
  • (3R,4R)-1-BENZYL-N,4-DIMETHYLPIPERIDIN-3-AMINE DIHYDROCHLORID
  • 3-Piperidinamine, N,4-dimethyl-1-(phenylmethyl)-, dihydrochloride, (3R,4R)-
  • Tofacitinib intermediate 3
  • (3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine HCl
  • (3R,4R)-(1-Benzyl-4-methyl-piperidin-3-yl)-methyl-amine dihydrochloride
  • (3R,4R)-1-Benzyl-3-(methylamino)-4-methylpiperidine Dihydrochloride
  • TOF30
  • Tofacitinib-1
  • Cis 1-benzyl-4-methyl-3-methylamino-piperidine hydrochloride
  • (3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine, hydrochloride (1:2)
  • piperidin-3-amine dihydrochL
  • (3R,?4R)?-N,?4-?Dimethyl-?1-?(phenylmethyl)?-3-?piperidinamine Dihydrochloride
  • Cis-n-benzyl-3-methylamino-4-methyl-piperidine bis-(, HCl )
  • (3R,4R)-1-BENZYL-N,4-DIMETHYLPIPERIDIN-3-AMINEDITYDROCHLORIDE
  • (3R,4R)-1-BENZYL-N,4-DIMETHYLPIPERIDIN-3-AMINE 2HCL
  • Tofacitinib Impurity 5 Dihydrochloride
  • N-((3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride
  • (3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydro...
  • Azilsartan medoxomil impurity351
  • (3R,4R)-N, 4-dimethyl-1 -(phenylmethyl) -3-piperidamine hydrochloride
  • (3R,4R)-N,4-Dimethy1-(phenylmethyl)-3-piperidinamine hydrochloride
  • CIS-N-BENZYL-3-METHYLAMINO-4-METHYL-PIPERIDINE BIS-(HYDROCHLORIDE) Tofacitinib （Int.）
  • Tofacitinib Impurity 123 DiHCl
  • (3R,4R)-N,4-Dimethyl-1-(benzyl)-3-piperidinamine 2HCl
  • (3R,4R)-1-Benzyl-N,4-dimethyl-3-piperidinamine dihydrochloride
  • Tofatinib Impurity 5
  • 3-Piperidinamine, N,4-dimethyl-1-(phenylmethyl)-, hydrochloride (1:2), (3R,4R)- - [P15037]
  • (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihcl
  • 1062580-52-2
  • C14H22N22HCl
  • 1