(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride

Product Name: (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride
CAS No.: 1062580-52-2
Chemical Name: (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride
Synonyms: (3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride;TOF30;Tofacitinib-1;Tofatinib Impurity 5;Tofacitinib interMediate A;Tofacitinib intermediate 3;piperidin-3-amine dihydrochL;Tofacitinib Impurity 123 DiHCl;Azilsartan medoxomil impurity351;Tofacitinib Impurity 5 Dihydrochloride
CBNumber: CB21011155
Molecular Formula: C14H23ClN2
Formula Weight: 254.8
MOL File: Mol file

More

Less

(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Property

Melting point:: 249～251℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Aqueous Acid (Slightly), DMSO (Slightly, Heated, Sonicated), Methanol (Slightly)
form: Solid
color: White to Off-White
InChI: InChI=1/C14H22N2.ClH/c1-12-8-9-16(11-14(12)15-2)10-13-6-4-3-5-7-13;/h3-7,12,14-15H,8-11H2,1-2H3;1H/t12-,14+;/s3
InChIKey: FVRZQLQXDPJADE-WLZBWWFYNA-N
SMILES: C(C1C=CC=CC=1)N1CC[C@@H](C)[C@@H](NC)C1.Cl |&1:10,12,r|

More

Less

Safety

HazardClass: IRRITANT
HS Code: 2933399990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

TRC

Product number: D480190
Product name: (3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamineDihydrochloride
Packaging: 10g
Price: $235
Updated: 2021/12/16

Apolloscientific

Product number: OR54340
Product name: cis-1-Benzyl-4-methyl-3-(methylamino)piperidine dihydrochloride
Purity: 95+%
Packaging: 25g
Price: $311
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H31-5-2Q
Product name: (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-aminedihydrochloride
Purity: 97.0%
Packaging: 1g
Price: $490
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 35378
Product name: (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-aminedHCl
Purity: 95+%
Packaging: 1000mg
Price: $550
Updated: 2021/12/16

AK Scientific

Product number: 1409AA
Product name: (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-aminedihydrochloride
Packaging: 1g
Price: $72
Updated: 2021/12/16

More

Less

(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Chemical Properties,Usage,Production

Uses

(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes.

Uses

(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride is a related compound of Tofacitinib (T528000). (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride can be used to prepare janus kinase 1 selective inhibitor.

Synthesis

TiCl4(0.2g, 1mmol) and NEt3(0.15 g, 1.5 mmol) were added to toluene, and then add 1-benzyl-4-methyl-3-ketone piperidine (20.3 g, 100 mmol) at 35 ℃. The methylamine solution is added to the reaction solution (9.32 g, 120 mmol) and reaction for 4 h, followed by adding NaBH (OAC) 3 (0.32 g, 1.5 mmol) and glacial acetic acid 2 ml. After the reaction is complete, add saturated salt water to wash the reaction mixture. (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride was obtained after further purification.

(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Suppliers

China 325 India 9 United Kingdom 3 United States 15 Global 352

Henan Lingbei Biotechnology Co., Ltd

Tel: 86-18539896799 18539896799
Email: 71889632@qq.com
Country: China
ProdList: 115
Advantage: 58

Shanghai Boc Chemical Co.,Ltd

Tel: 021-34975603-808 18721111801
Fax: +86-21-34975602-805
Email: sales@bocpharma.com
Country: China
ProdList: 994
Advantage: 64

Bayee Biotech (Anqing) Co., Ltd.

Tel: 0556-5032306 18917961636
Fax: +86-556-5032307
Email: wtx@bayeebio.com
Country: China
ProdList: 253
Advantage: 61

Zhuhai Yourun Co., Ltd.

Tel: 0756-6811852 13923369215
Fax: 0756-6811857
Email: zhuhaiyourun@126.com
Country: China
ProdList: 128
Advantage: 55

Suli Pharmaceutical Technology Co., Ltd.

Tel: 021-021-58086325-8012-8012 13636568474
Fax: 021-51972827
Email: yingjie.zhang@suli.com
Country: China
ProdList: 103
Advantage: 58

Gansu HaoTian Chemical Technology Co., Ltd.

Tel: 0943-6900332 17789447501
Fax: 0931-8238232
Email: zhuanxiajiang@haotianpharm.com
Country: China
ProdList: 113
Advantage: 55

Shanghai Shanyuan pharmaceutical technology co., LTD

Tel: 021-31761238 13167072949
Fax: 021-31761238
Email: 3146446224@qq.com
Country: China
ProdList: 1609
Advantage: 55

Shanxi Xinsheng Biotechnology Co., Ltd

Tel: 15835826763
Email: 997855689@qq.com
Country: China
ProdList: 111
Advantage: 58

Purest Pharmaceuticl （Xi’an) Co,.LTD

Tel: +86-13893405577 +86-13522261260
Email: 12829054@qq.com
Country: China
ProdList: 72
Advantage: 58

PharmaBlock Sciences (Nanjing),Inc.

Tel: 400-0255188 4000255188
Fax: 86-025-86918232
Email: sales@pharmablock.com
Country: China
ProdList: 5268
Advantage: 55

More

Less

View Lastest Price from (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride manufacturers

hebei hongtan Biotechnology Co., Ltd

Product: (3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride 1062580-52-2
Price: US $30.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 2000kg
Release date: 2024-03-22

Shanghai Joiny Pharmaceutical Co.,LTD

Product: (3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride 1062580-52-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500kg
Release date: 2022-09-23

Hangzhou ICH Biofarm Co., Ltd

Product: (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride 1062580-52-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500KG
Release date: 2023-07-06

1062580-52-2, (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochlorideRelated Search:

(1-Benzyl-4-Methyl-1,2,5,6-tetrahydropyridin-3-yl)carbaMic acid Methyl ester Methyl (1-benzyl-4-Methylpiperidin-3-yl)carbaMate 13-Deoxyepirubicin 3-((3R,4S)-4-Methyl-3-(Methyl(7H-pyrrolo[2,3-d]pyriMidin-4-yl)aMino)piperidin-1-yl)-3-oxopropanenitrile 3-METHOXYCARBONYLAMINO-4-METHYLPYRIDINE 1-[2-(2-methoxyphenoxy)ethylamino]-3-(9-methylcarbazol-4-yl)oxypropan-2-ol:hydrochloride Methyl (4-Methylpiperidin-3-yl)carbaMate 3-((3S,4R)-4-Methyl-3-(Methyl(7H-pyrrolo[2,3-d]pyriMidin-4-yl)aMino)piperidin-1-yl)-3-oxopropanenitrile 3-PiperidinaMine, 1-acetyl-N,4-diMethyl-N-1H-pyrrolo[2,3-d]pyriMidin-4-yl-, (3R,4R)- (9CI) 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine 2,4-DICHLORO-7H-PYRROLO2,3-DPYRIMIDINE 7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]-7-[(4-Met hylphenyl)sulfonyl]- 4-CHLORO-7-TOSYL-7H-PYRROLO[2,3-D]PYRIMIDINE Tofacitinib citrate 3-bis(4-Methylbenzoyloxy)succinate)

CIS-N-BENZYL-3-METHYLAMINO-4-METHYL-PIPERIDINE BIS-(HYDROCHLORIDE)

cis-1-Benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride

cis-1-Benzyl-4-methyl-3-(methylamino)piperidine dihydrochloride 95+%

cis-1-Benzyl-N3,4-dimethylpiperidin-3-amine dihydrochloride

(3R,4R)-1-BENZYL-N,4-DIMETHYLPIPERIDIN-3-AMINE DIHYDROCHLORIDE

(3R,4R)-1-benzyl-N,4-diMethylpiperidin-3-aMine BIS-(HYDROCHLORIDE)

(3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride

3-PiperidinaMine, N,4-diMethyl-1-(phenylMethyl)-, hydrochloride (1:2), (3R,4R)-

(3R,4R)-N,4-DiMethyl-1-(phenylMethyl)-3-piperidi

(3R,4R)- Cis-1-benzyl-4-Methyl-3-(MethylaMino)piperidine

Tofacitinib interMediate A

(3R,4R)- cis-1-Benzyl-4-Methyl-3-(MethylaMino)piperidine dihydrochloride

(3R,4R)-1-BENZYL-N,4-DIMETHYLPIPERIDIN-3-AMINE DIHYDROCHLORID

3-Piperidinamine, N,4-dimethyl-1-(phenylmethyl)-, dihydrochloride, (3R,4R)-

Tofacitinib intermediate 3

(3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine HCl

(3R,4R)-(1-Benzyl-4-methyl-piperidin-3-yl)-methyl-amine dihydrochloride

(3R,4R)-1-Benzyl-3-(methylamino)-4-methylpiperidine Dihydrochloride

TOF30

Tofacitinib-1

Cis 1-benzyl-4-methyl-3-methylamino-piperidine hydrochloride

(3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine, hydrochloride (1:2)

piperidin-3-amine dihydrochL

(3R,?4R)?-N,?4-?Dimethyl-?1-?(phenylmethyl)?-3-?piperidinamine Dihydrochloride

Cis-n-benzyl-3-methylamino-4-methyl-piperidine bis-(, HCl )

(3R,4R)-1-BENZYL-N,4-DIMETHYLPIPERIDIN-3-AMINEDITYDROCHLORIDE

(3R,4R)-1-BENZYL-N,4-DIMETHYLPIPERIDIN-3-AMINE 2HCL

Tofacitinib Impurity 5 Dihydrochloride

N-((3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride

(3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydro...

Azilsartan medoxomil impurity351

(3R,4R)-N, 4-dimethyl-1 -(phenylmethyl) -3-piperidamine hydrochloride

Tofatinib Impurity 5

(3R,4R)-N,4-Dimethy1-(phenylmethyl)-3-piperidinamine hydrochloride

CIS-N-BENZYL-3-METHYLAMINO-4-METHYL-PIPERIDINE BIS-(HYDROCHLORIDE) Tofacitinib （Int.）

Tofacitinib Impurity 123 DiHCl

(3R,4R)-N,4-Dimethyl-1-(benzyl)-3-piperidinamine 2HCl

(3R,4R)-1-Benzyl-N,4-dimethyl-3-piperidinamine dihydrochloride

1062580-52-2

C14H22N22HCl

1