ChemicalBook > CAS DataBase List > (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride
(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride
- Product Name
- (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride
- CAS No.
- 1062580-52-2
- Chemical Name
- (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride
- Synonyms
- (3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride;TOF30;Tofacitinib-1;Tofatinib Impurity 5;Tofacitinib interMediate A;Tofacitinib intermediate 3;piperidin-3-amine dihydrochL;Tofacitinib Impurity 123 DiHCl;Azilsartan medoxomil impurity351;Tofacitinib Impurity 5 Dihydrochloride
- CBNumber
- CB21011155
- Molecular Formula
- C14H23ClN2
- Formula Weight
- 254.8
- MOL File
- Mol file
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(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Property
- Melting point:
- 249～251℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Aqueous Acid (Slightly), DMSO (Slightly, Heated, Sonicated), Methanol (Slightly)
- form
- Solid
- color
- White to Off-White
- InChI
- InChI=1/C14H22N2.ClH/c1-12-8-9-16(11-14(12)15-2)10-13-6-4-3-5-7-13;/h3-7,12,14-15H,8-11H2,1-2H3;1H/t12-,14+;/s3
- InChIKey
- FVRZQLQXDPJADE-WLZBWWFYNA-N
- SMILES
- C(C1C=CC=CC=1)N1CC[C@@H](C)[C@@H](NC)C1.Cl |&1:10,12,r|
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Safety
- HazardClass
- IRRITANT
- HS Code
- 2933399990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
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N-Bromosuccinimide Price
TRC
- Product number
- D480190
- Product name
- (3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamineDihydrochloride
- Packaging
- 10g
- Price
- $235
- Updated
- 2021/12/16
Apolloscientific
- Product number
- OR54340
- Product name
- cis-1-Benzyl-4-methyl-3-(methylamino)piperidine dihydrochloride
- Purity
- 95+%
- Packaging
- 25g
- Price
- $311
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 3H31-5-2Q
- Product name
- (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-aminedihydrochloride
- Purity
- 97.0%
- Packaging
- 1g
- Price
- $490
- Updated
- 2021/12/16
Medical Isotopes, Inc.
- Product number
- 35378
- Product name
- (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-aminedHCl
- Purity
- 95+%
- Packaging
- 1000mg
- Price
- $550
- Updated
- 2021/12/16
AK Scientific
- Product number
- 1409AA
- Product name
- (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-aminedihydrochloride
- Packaging
- 1g
- Price
- $72
- Updated
- 2021/12/16
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(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Chemical Properties,Usage,Production
Uses
(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes.
Uses
(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride is a related compound of Tofacitinib (T528000). (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride can be used to prepare janus kinase 1 selective inhibitor.
Synthesis
TiCl4(0.2g, 1mmol) and NEt3(0.15 g, 1.5 mmol) were added to toluene, and then add 1-benzyl-4-methyl-3-ketone piperidine (20.3 g, 100 mmol) at 35 ℃. The methylamine solution is added to the reaction solution (9.32 g, 120 mmol) and reaction for 4 h, followed by adding NaBH (OAC) 3 (0.32 g, 1.5 mmol) and glacial acetic acid 2 ml. After the reaction is complete, add saturated salt water to wash the reaction mixture. (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride was obtained after further purification.
(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride manufacturers
hebei hongtan Biotechnology Co., Ltd
- Product
- (3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride 1062580-52-2
- Price
- US $30.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 2000kg
- Release date
- 2024-05-17
Shanghai Joiny Pharmaceutical Co.,LTD
- Product
- (3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride 1062580-52-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2024-12-05
Shaanxi Dideu New Materials Co. Ltd
- Product
- (3R,4R)-1-Benzyl-N,4-diMethylpiperidin-3-aMine dihydrochloride 1062580-52-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2024-11-14
1062580-52-2, (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochlorideRelated Search:
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