3-amino-5-bromopyridine-2-carboxylic acid
- Product Name
- 3-amino-5-bromopyridine-2-carboxylic acid
- CAS No.
- 870997-85-6
- Chemical Name
- 3-amino-5-bromopyridine-2-carboxylic acid
- Synonyms
- 3-Amino-5-bromopicolinic acid;3-Amino-5-bromopyridine-2...;3-Amino 5-Bromo 2-Carboxylic Acid;3-AMino-5-broMopyridine-2-carboxylic;3-AMino-5-broMopyridin-2-carboxylic acid;3-amino-5-bromopyridine-2-carboxylic acid;3-amino-5-bromo-2-Pyridinecarboxylic acid;2-Pyridinecarboxylic acid, 3-aMino-5-broMo-
- CBNumber
- CB01558713
- Molecular Formula
- C6H5BrN2O2
- Formula Weight
- 217.02
- MOL File
- 870997-85-6.mol
3-amino-5-bromopyridine-2-carboxylic acid Property
- Melting point:
- >170°C (dec.)
- Boiling point:
- 399.0±42.0 °C(Predicted)
- Density
- 1.909±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 4.15±0.10(Predicted)
- color
- Yellow
- InChI
- InChI=1S/C6H5BrN2O2/c7-3-1-4(8)5(6(10)11)9-2-3/h1-2H,8H2,(H,10,11)
- InChIKey
- GXXIHPZAIYKHGG-UHFFFAOYSA-N
- SMILES
- C1(C(O)=O)=NC=C(Br)C=C1N
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
N-Bromosuccinimide Price
- Product number
- ADE000138
- Product name
- 3-Amino-5-bromopicolinic acid
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $761
- Updated
- 2023/01/07
- Product number
- A594990
- Product name
- 3-Amino-5-bromopyridine-2-carboxylicacid
- Packaging
- 1g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- 4H57-9-02
- Product name
- 3-Amino-5-bromopyridine-2-carboxylic acid
- Packaging
- 1g
- Price
- $125
- Updated
- 2021/12/16
- Product number
- FA139402
- Product name
- 3-Amino-5-bromopicolinic acid
- Packaging
- 5G
- Price
- $141
- Updated
- 2021/12/16
- Product number
- V8292
- Product name
- 3-Amino-5-bromopyridine-2-carboxylicacid
- Packaging
- 250mg
- Price
- $15
- Updated
- 2021/12/16
3-amino-5-bromopyridine-2-carboxylic acid Chemical Properties,Usage,Production
Uses
3-amino-5-bromopyridine-2-carboxylic acid is used in the preparation of biological reagents such as macrocyclic glucagon-like peptide 1 receptor agonists. It is also used in the preparation of pyridinamide and indoline compounds.
Synthesis
669066-89-1
870997-85-6
Step 2: Synthesis of 3-amino-5-bromopyridine-2-carboxylic acid To a 100 mL round bottom flask was added 3-amino-5-bromopyridine-2-carboxamide (1.05 g, 4.9 mmol) and aqueous sodium hydroxide solution (0.98 g dissolved in 10 mL of water, 24.5 mmol). The reaction mixture was heated to reflux temperature and stirred for 5 hours. Upon completion of the reaction, volatiles were removed by distillation under reduced pressure to give a residue. The residue was neutralized with 2N HCl at 0 °C to pH=7.0 and precipitate was precipitated. The precipitate was collected by filtration and dried to give 3-amino-5-bromopyridine-2-carboxylic acid as a light yellow solid (1 g, 95% yield). 1H NMR (300 MHz, DMSO-d6): δ 7.65 (d, J=2.1 Hz, 1H), 7.20 (d, J=2.1 Hz, 1H), 7.01-7.16 (br s, 2H). LC-MS (ESI): calculated: 215.9; measured: 217.0 [M+H]+ (RT: 0.43 min).
References
[1] Patent: WO2012/58671, 2012, A1. Location in patent: Page/Page column 117-118
[2] Patent: US2014/38952, 2014, A1. Location in patent: Page/Page column 0180-0181
[3] Patent: EP1757594, 2007, A1. Location in patent: Page/Page column 77
[4] Patent: WO2008/76425, 2008, A1. Location in patent: Page/Page column 33
[5] Patent: WO2008/130600, 2008, A2. Location in patent: Page/Page column 56
3-amino-5-bromopyridine-2-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
3-amino-5-bromopyridine-2-carboxylic acid Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from 3-amino-5-bromopyridine-2-carboxylic acid manufacturers
- Product
- 3-Amino-5-bromopicolinicacid 870997-85-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.0001kg
- Purity
- 98%min
- Supply Ability
- 100kgs/month
- Release date
- 2022-05-09
- Product
- 3-amino-5-bromopyridine-2-carboxylic acid 870997-85-6
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2020-01-10