7-fluoro-1H-indazole-3-carboxylic acid
- Product Name
- 7-fluoro-1H-indazole-3-carboxylic acid
- CAS No.
- 959236-59-0
- Chemical Name
- 7-fluoro-1H-indazole-3-carboxylic acid
- Synonyms
- 3-Carboxy-7-fluoro-1H-indazole;7-Fluoroindazole-3-carboxylic acid;2-Thiazolidinethione,4-phenyl-,(9R)-;1-Pyrrolidinepropanoicacid,2,9-dioxo-;7-fluoro-2H-indazole-3-carboxylic acid;7-fluoro-1H-indazole-3-carboxylic acid;1H-Indazole-3-carboxylic acid, 7-fluoro-
- CBNumber
- CB01560321
- Molecular Formula
- C8H5FN2O2
- Formula Weight
- 180.14
- MOL File
- 959236-59-0.mol
7-fluoro-1H-indazole-3-carboxylic acid Property
- Boiling point:
- 445.9±25.0 °C(Predicted)
- Density
- 1.611
- storage temp.
- 2-8°C
- pka
- 2.70±0.10(Predicted)
- Appearance
- Light brown to brown Solid
Safety
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F600565
- Product name
- 7-Fluoro-1H-indazole-3-carboxylicacid
- Packaging
- 50mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- F600565
- Product name
- 7-Fluoro-1H-indazole-3-carboxylicacid
- Packaging
- 100mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- 071228
- Product name
- 7-Fluoro-1H-indazole-3-carboxylic acid
- Purity
- 97%
- Packaging
- 5g
- Price
- $585
- Updated
- 2021/12/16
- Product number
- HCH0044899
- Product name
- 7-FLUORO-1H-INDAZOLE-3-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1426.43
- Updated
- 2021/12/16
- Product number
- 4H21-3-U3
- Product name
- 7-Fluoro-1H-indazole-3-carboxylic acid
- Purity
- 95.0%
- Packaging
- 250mg
- Price
- $112
- Updated
- 2021/12/16
7-fluoro-1H-indazole-3-carboxylic acid Chemical Properties,Usage,Production
Synthesis
317-20-4
959236-59-0
The general procedure for the synthesis of 7-fluoro-1H-indazole-3-carboxylic acid from 7-fluoroindolomanedione was carried out as follows: with reference to the methodology reported by Johnson, B.L. and Rogers, J.D. in Syn. Commun. 2005, 35, 2681-2684. First, 5.28 g of 7-fluoroindigo was suspended in 30 mL of water under stirring conditions, followed by the addition of a solution of 1.30 g NaOH dissolved in 10 mL of water. Stirring was continued until all solids were completely dissolved to form a deep red solution, which was subsequently cooled in an ice water bath. Next, a pre-cooled (ice bath) solution of 2.21 g NaNO2 dissolved in 10 mL of water was slowly added. The mixed solution was slowly added dropwise to the pre-cooled (ice bath) aqueous sulfuric acid solution (3.4 mL of H2SO4 dissolved in 60 mL of water), with ice being added during the process to maintain the temperature at approximately 0°C. After stirring for about 10 minutes, the dark red diazo solution was slowly added to a pre-cooled (0°C, ice bath) solution of 18 g SnCl2-2H2O dissolved in 30 mL of concentrated HCl, and ice was continued to be added to maintain the temperature at about 0°C. After the reaction mixture was stirred for about 1 h, filtration was performed and the resulting residue was dissolved in 60 mL of 1N NaOH and washed with ether (2 x 50 mL). The yellow-brown solution obtained was cooled in an ice bath and acidified with concentrated HCl to pH 3 (detected using litmus paper), at which point a dark yellow precipitate precipitated. The precipitate was collected by filtration, washed with water and dried in an oven overnight to give 3.69 g (47% yield) of 7-fluoro-1H-indazole-3-carboxylic acid as an orange solid. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 14.35 (br s, 1H), 13.22 (br s, 1H), 7.89-7.87 (m, 1H), 7.26-7.21 (m, 2H). m/z MS (ESI) m/z 181 (M + H)+.
References
[1] Patent: US2011/28447, 2011, A1. Location in patent: Page/Page column 40
7-fluoro-1H-indazole-3-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 7-fluoro-1H-indazole-3-carboxylic acid manufacturers
- Product
- 7-fluoro-1H-indazole-3-carboxylic acid 959236-59-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-03-11