3-Bromo-4-(bromomethyl)benzonitrile
- Product Name
- 3-Bromo-4-(bromomethyl)benzonitrile
- CAS No.
- 89892-39-7
- Chemical Name
- 3-Bromo-4-(bromomethyl)benzonitrile
- Synonyms
- NSC 149637;2-Bromo-4-cyanobenzyl bromide;3-broMo-4-(broMoMethyl)benzonitrile;2-Bromo-1-bromomethyl-4-cyanobenzene;Benzonitrile, 3-bromo-4-(bromomethyl)-
- CBNumber
- CB01563645
- Molecular Formula
- C8H5Br2N
- Formula Weight
- 274.94
- MOL File
- 89892-39-7.mol
3-Bromo-4-(bromomethyl)benzonitrile Property
- Boiling point:
- 319.3±32.0 °C(Predicted)
- Density
- 1.92
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- White to off-white Solid
Safety
- RIDADR
- 3439
- HazardClass
- 6.1
- PackingGroup
- Ⅲ
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H314Causes severe skin burns and eye damage
H318Causes serious eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P363Wash contaminated clothing before reuse.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B683288
- Product name
- 2-Bromo-4-cyanobenzylbromide
- Packaging
- 250mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FB63890
- Product name
- 2-Bromo-4-cyanobenzyl bromide
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FB63890
- Product name
- 2-Bromo-4-cyanobenzyl bromide
- Packaging
- 500mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- FB63890
- Product name
- 2-Bromo-4-cyanobenzyl bromide
- Packaging
- 1g
- Price
- $190
- Updated
- 2021/12/16
- Product number
- FB63890
- Product name
- 2-Bromo-4-cyanobenzyl bromide
- Packaging
- 2g
- Price
- $300
- Updated
- 2021/12/16
3-Bromo-4-(bromomethyl)benzonitrile Chemical Properties,Usage,Production
Uses
3-Bromo-4-(bromomethyl)benzonitrile is a nitrile compound that can be used in the synthesis of other organic heterocyclic compounds or pharmaceutical preparations, such as glucagon-like peptide-1 receptor (GLP-1R) modulating compounds.
Synthesis
42872-74-2
89892-39-7
To a stirred solution of 3-bromo-4-methylbenzonitrile (2 g, 10.2014 mmol, 100% purity) in carbon tetrachloride (20 mL, 100% purity) under argon protection was sequentially added N-bromosuccinimide (NBS, 2.2 g, 12.2417 mmol, 99% purity) and benzoyl peroxide (0.123 g 0.5101 mmol, 100% purity). The reaction mixture was heated to 85°C and the reaction was stirred at this temperature for 18 hours. Upon completion of the reaction, the reaction mixture was diluted with water (50 mL) and extracted with ethyl acetate. The organic phases were combined, washed sequentially with water and saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford 3-bromo-4-(bromomethyl)benzonitrile (1.2 g, 4.4 mmol, 90% purity, 95% yield) as an off-white solid. The product was confirmed by 1H NMR (400 MHz, CDCl3): δ 3.89-4.01 (m, 2H), 6.61-6.77 (m, 1H), 6.92-7.07 (m, 2H). LCMS analysis showed retention times of 1.12-1.49 min, m/z 274 [M+H]+.
References
[1] Patent: WO2016/113303, 2016, A1. Location in patent: Page/Page column 41
[2] Journal of the American Chemical Society, 2017, vol. 139, # 2, p. 829 - 835
[3] Journal of the American Chemical Society, 2009, vol. 131, # 39, p. 13908 - 13909
[4] Patent: EP2927219, 2015, A1. Location in patent: Paragraph 0130; 0132
[5] Journal of Organic Chemistry, 1964, vol. 29, p. 2034 - 2036
3-Bromo-4-(bromomethyl)benzonitrile Preparation Products And Raw materials
Raw materials
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View Lastest Price from 3-Bromo-4-(bromomethyl)benzonitrile manufacturers
- Product
- 3-Bromo-4-(bromomethyl)benzonitrile 89892-39-7
- Price
- US $2.20-8.80/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 50kg
- Release date
- 2025-06-25
- Product
- 2-Bromo-4-cyanobenzyl bromide 89892-39-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-18
- Product
- 2-Bromo-4-cyanobenzyl bromide 89892-39-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%Min
- Supply Ability
- 1000kg
- Release date
- 2023-03-14