3-Bromo-4-(bromomethyl)benzonitrile

Product Name: 3-Bromo-4-(bromomethyl)benzonitrile
CAS No.: 89892-39-7
Chemical Name: 3-Bromo-4-(bromomethyl)benzonitrile
Synonyms: NSC 149637;2-Bromo-4-cyanobenzyl bromide;3-broMo-4-(broMoMethyl)benzonitrile;2-Bromo-1-bromomethyl-4-cyanobenzene;Benzonitrile, 3-bromo-4-(bromomethyl)-
CBNumber: CB01563645
Molecular Formula: C8H5Br2N
Formula Weight: 274.94
MOL File: 89892-39-7.mol

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3-Bromo-4-(bromomethyl)benzonitrile Property

Boiling point:: 319.3±32.0 °C(Predicted)
Density: 1.92
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
Appearance: White to off-white Solid

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Safety

RIDADR: 3439
HazardClass: 6.1
PackingGroup: Ⅲ

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B683288
Product name: 2-Bromo-4-cyanobenzylbromide
Packaging: 250mg
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB63890
Product name: 2-Bromo-4-cyanobenzyl bromide
Packaging: 250mg
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB63890
Product name: 2-Bromo-4-cyanobenzyl bromide
Packaging: 500mg
Price: $120
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB63890
Product name: 2-Bromo-4-cyanobenzyl bromide
Packaging: 1g
Price: $190
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB63890
Product name: 2-Bromo-4-cyanobenzyl bromide
Packaging: 2g
Price: $300
Updated: 2021/12/16

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3-Bromo-4-(bromomethyl)benzonitrile Chemical Properties,Usage,Production

Uses

3-Bromo-4-(bromomethyl)benzonitrile is a nitrile compound that can be used in the synthesis of other organic heterocyclic compounds or pharmaceutical preparations, such as glucagon-like peptide-1 receptor (GLP-1R) modulating compounds.

Synthesis

42872-74-2

89892-39-7

To a stirred solution of 3-bromo-4-methylbenzonitrile (2 g, 10.2014 mmol, 100% purity) in carbon tetrachloride (20 mL, 100% purity) under argon protection was sequentially added N-bromosuccinimide (NBS, 2.2 g, 12.2417 mmol, 99% purity) and benzoyl peroxide (0.123 g 0.5101 mmol, 100% purity). The reaction mixture was heated to 85°C and the reaction was stirred at this temperature for 18 hours. Upon completion of the reaction, the reaction mixture was diluted with water (50 mL) and extracted with ethyl acetate. The organic phases were combined, washed sequentially with water and saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford 3-bromo-4-(bromomethyl)benzonitrile (1.2 g, 4.4 mmol, 90% purity, 95% yield) as an off-white solid. The product was confirmed by 1H NMR (400 MHz, CDCl3): δ 3.89-4.01 (m, 2H), 6.61-6.77 (m, 1H), 6.92-7.07 (m, 2H). LCMS analysis showed retention times of 1.12-1.49 min, m/z 274 [M+H]+.

References

[1] Patent: WO2016/113303, 2016, A1. Location in patent: Page/Page column 41
[2] Journal of the American Chemical Society, 2017, vol. 139, # 2, p. 829 - 835
[3] Journal of the American Chemical Society, 2009, vol. 131, # 39, p. 13908 - 13909
[4] Patent: EP2927219, 2015, A1. Location in patent: Paragraph 0130; 0132
[5] Journal of Organic Chemistry, 1964, vol. 29, p. 2034 - 2036

3-Bromo-4-(bromomethyl)benzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Bromo-4-(bromomethyl)benzonitrile Suppliers

China 82 India 1 Switzerland 1 United Kingdom 2 United States 9 Global 95

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View Lastest Price from 3-Bromo-4-(bromomethyl)benzonitrile manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 3-Bromo-4-(bromomethyl)benzonitrile 89892-39-7
Price: US $2.20-8.80/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 50kg
Release date: 2025-06-25

Henan Aochuang Chemical Co.,Ltd.

Product: 2-Bromo-4-cyanobenzyl bromide 89892-39-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-18

LY Global chemicals co.,ltd .

Product: 2-Bromo-4-cyanobenzyl bromide 89892-39-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%Min
Supply Ability: 1000kg
Release date: 2023-03-14

89892-39-7, 3-Bromo-4-(bromomethyl)benzonitrileRelated Search:

3-Bromo-4-methylbenzonitrile 4-Cyanobenzyl bromide 2-Bromo-4-cyanobenzyl bromide

2-Bromo-4-cyanobenzyl bromide

2-Bromo-1-bromomethyl-4-cyanobenzene

NSC 149637

3-broMo-4-(broMoMethyl)benzonitrile

Benzonitrile, 3-bromo-4-(bromomethyl)-

89892-39-7