ChemicalBook > CAS DataBase List > 2'',3'',5''-Triacetyl -azacytidine

2'',3'',5''-Triacetyl -azacytidine

Product Name
2'',3'',5''-Triacetyl -azacytidine
CAS No.
10302-78-0
Chemical Name
2'',3'',5''-Triacetyl -azacytidine
Synonyms
Nsc291930;-O-triacetate;Triacetyl azacitidine;Azacitidine Triacetate;Azacitidine Impurity 48;Intermediate of Azacitidine;2'3'5'-triacetyl-5-Azacytosine;2',3',5'-triacetyl-5-Azacytidine;2',3',5'-Tri-O-Acetyl-Azacytidine;2'',3'',5''-Triacetyl -azacytidine
CBNumber
CB01564248
Molecular Formula
C14H18N4O8
Formula Weight
370.31
MOL File
10302-78-0.mol
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2'',3'',5''-Triacetyl -azacytidine Property

Boiling point:
497.3±55.0 °C(Predicted)
Density 
1.60±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
form 
crystalline solid
pka
3.06±0.20(Predicted)
CAS DataBase Reference
10302-78-0
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
13373
Product name
2',3',5'-triacetyl-5-Azacytidine
Purity
≥95%
Packaging
5mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
13373
Product name
2',3',5'-triacetyl-5-Azacytidine
Purity
≥95%
Packaging
10mg
Price
$115
Updated
2024/03/01
Cayman Chemical
Product number
13373
Product name
2',3',5'-triacetyl-5-Azacytidine
Purity
≥95%
Packaging
50mg
Price
$477
Updated
2024/03/01
Cayman Chemical
Product number
13373
Product name
2',3',5'-triacetyl-5-Azacytidine
Purity
≥95%
Packaging
100mg
Price
$834
Updated
2024/03/01
TRC
Product number
A796030
Product name
5-Azacytidine2’,3’5’-O-triacetate
Packaging
50mg
Price
$265
Updated
2021/12/16
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2'',3'',5''-Triacetyl -azacytidine Chemical Properties,Usage,Production

Description

5-Azacytidine is an inhibitor of DNA methyltransferase, potentially serving to reverse epigenetic changes. It reduces hypermethylation associated with certain diseases, including myelodysplastic syndromes and cancer. 2’,3’,5’-triacetyl-5-Azacytidine is a prodrug form of 5-azacytidine that may be rapidly absorbed orally without formation of major metabolites in the gastrointestinal tract.

Chemical Properties

White to off-white powder

Uses

5-Azacytidine is an inhibitor of DNA methyltransferaes, potentially serving to reverse epigenetic changes. It reduces hypermethylation associated with certain diseases, including myelodysplastic syndromes and cancer. 2’,3’,5’-triacetyl-5-Azacytidine is a prodrug form of 5-azacytidine that may be rapidly absorbed orally without formation of major metabolites in the gastrointestinal tract.[Cayman Chemical]

in vivo

in cd-1 mice, oral administration of tac for five days per week for 2 weeks didn’t result in animal deaths and weight loss, but induced changes in hematological parameters, lymph nodes, bone marrow, and duodenal epithelium. tac inhibited global dna methylation in the spleen and gut. in an in vivo l1210 leukemia model, tac exhibited antineoplastic activity [1].

References

[1] ziemba a, ramirez m c, freeman b, et al. abstract# 3369: development of oral demethylating agents for the treatment of myelodysplastic syndrome[j]. 2009.
[2] brueckner b, boy r g, siedlecki p, et al. epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human dna methyltransferases[j]. cancer research, 2005, 65(14): 6305-6311.

2'',3'',5''-Triacetyl -azacytidine Preparation Products And Raw materials

Raw materials

Preparation Products

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2'',3'',5''-Triacetyl -azacytidine Suppliers

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View Lastest Price from 2'',3'',5''-Triacetyl -azacytidine manufacturers

Henan Fengda Chemical Co., Ltd
Product
2'',3'',5''-Triacetyl -azacytidine 10302-78-0
Price
US $10.00-3.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-29
Henan Aochuang Chemical Co.,Ltd.
Product
2'',3'',5''-Triacetyl -azacytidine 10302-78-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-26

10302-78-0, 2'',3'',5''-Triacetyl -azacytidineRelated Search:

Fazarabine Azacitidine Impurity 34 L-Cytidine 1-(diaminomethylidene)-3-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]urea 1,2,3,5-TETRA-O-ACETYL-BETA-L-XYLOFURANOSE Azacitidine Impurity 31 AMMELINE Azacitidine Impurity 33 5,6-dihydro-5-azacytidine Ammeline-13C3 5-Azacitidine 5'-Diphosphate (2-aminoethyl)carbamic acid Diazenecarboximidamide, N-(hydroxymethyl)-N-β-D-ribofuranosyl- 4-Amino-1-(2-O,3-O,5-O-tribenzoyl-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one β-D-Glucopyranose, 2-deoxy-2-[[[(1,2,3,4-tetrahydro-2,4-dioxo-5-pyrimidinyl)amino]thioxomethyl]amino]- Azacitidine Impurity 30 Azacitidine Impurity 41 5-Aza-2'-deoxycytidine

  • 2'',3'',5''-Triacetyl -azacytidine
  • 1,3,5-Triazin-2(1H)-one, 4-amino-1-(2,3,5-tri-o-acetyl-.beta.-D-ribofuranosyl)-
  • Nsc291930
  • S-Triazin-2(1H)-one, 4-amino-1-.beta.-D-ribofuranosyl-, triacetate (ester)
  • 2',3',5'-triacetyl-5-Azacytidine
  • 1,3,5-Triazin-2(1H)-one, 4-aMino-1-(2,3,5-tri-O-acetyl-b-D-ribofuranosyl)-
  • (2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(4-amino-2-oxo-1,3,5-triazin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate
  • Intermediate of Azacitidine
  • 2'3'5'-triacetyl-5-Azacytosine
  • 2',3',5'-Tri-O-Acetyl-Azacytidine
  • Azacitidine Triacetate
  • Triacetyl azacitidine
  • 2,3,5-tri-O-acetyl-β-D-ribofuranose-4-amino-1,3,5-triazine
  • 1,3,5-Triazin-2(1H)-one, 4-amino-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-
  • -O-triacetate
  • 4-Amino-1-(2,3,5-tri-o-acetyl-beta-d-ribofuranosyl)-1,3,5-triazin-2(1h)-one
  • 5-Azacytidine 2’,3’5’-O-triacetate
  • 2,3,5-tri-O-acetyl-β-D-ribofuranose-4-amino-1,3,5-triazine
  • Azacitidine Impurity 48
  • 2'',3'',5''-Triacetyl -azacytidine
  • 2',3',5'-Tri-O-acetyl-5-azacytidine
  • 10302-78-0