2'',3'',5''-Triacetyl -azacytidine

Product Name: 2'',3'',5''-Triacetyl -azacytidine
CAS No.: 10302-78-0
Chemical Name: 2'',3'',5''-Triacetyl -azacytidine
Synonyms: Nsc291930;-O-triacetate;Triacetyl azacitidine;Azacitidine Triacetate;Azacitidine Impurity 48;Intermediate of Azacitidine;2'3'5'-triacetyl-5-Azacytosine;2'3'5'-triacetyl-5-Azacytosine;2',3',5'-triacetyl-5-Azacytidine;2',3',5'-Triacetyl-5-azacytidine
CBNumber: CB01564248
Molecular Formula: C14H18N4O8
Formula Weight: 370.31
MOL File: 10302-78-0.mol

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2'',3'',5''-Triacetyl -azacytidine Property

Boiling point:: 497.3±55.0 °C(Predicted)
Density: 1.60±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: ≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
form: crystalline solid
pka: 3.06±0.20(Predicted)
CAS DataBase Reference: 10302-78-0

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 13373
Product name: 2',3',5'-triacetyl-5-Azacytidine
Purity: ≥95%
Packaging: 5mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 13373
Product name: 2',3',5'-triacetyl-5-Azacytidine
Purity: ≥95%
Packaging: 10mg
Price: $115
Updated: 2024/03/01

Cayman Chemical

Product number: 13373
Product name: 2',3',5'-triacetyl-5-Azacytidine
Purity: ≥95%
Packaging: 50mg
Price: $477
Updated: 2024/03/01

Cayman Chemical

Product number: 13373
Product name: 2',3',5'-triacetyl-5-Azacytidine
Purity: ≥95%
Packaging: 100mg
Price: $834
Updated: 2024/03/01

TRC

Product number: A796030
Product name: 5-Azacytidine2’,3’5’-O-triacetate
Packaging: 50mg
Price: $265
Updated: 2021/12/16

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2'',3'',5''-Triacetyl -azacytidine Chemical Properties,Usage,Production

Description

5-Azacytidine is an inhibitor of DNA methyltransferase, potentially serving to reverse epigenetic changes. It reduces hypermethylation associated with certain diseases, including myelodysplastic syndromes and cancer. 2’,3’,5’-triacetyl-5-Azacytidine is a prodrug form of 5-azacytidine that may be rapidly absorbed orally without formation of major metabolites in the gastrointestinal tract.

Chemical Properties

White to off-white powder

Uses

5-Azacytidine is an inhibitor of DNA methyltransferaes, potentially serving to reverse epigenetic changes. It reduces hypermethylation associated with certain diseases, including myelodysplastic syndromes and cancer. 2’,3’,5’-triacetyl-5-Azacytidine is a prodrug form of 5-azacytidine that may be rapidly absorbed orally without formation of major metabolites in the gastrointestinal tract.[Cayman Chemical]

in vivo

in cd-1 mice, oral administration of tac for five days per week for 2 weeks didn’t result in animal deaths and weight loss, but induced changes in hematological parameters, lymph nodes, bone marrow, and duodenal epithelium. tac inhibited global dna methylation in the spleen and gut. in an in vivo l1210 leukemia model, tac exhibited antineoplastic activity [1].

References

[1] ziemba a, ramirez m c, freeman b, et al. abstract# 3369: development of oral demethylating agents for the treatment of myelodysplastic syndrome[j]. 2009.
[2] brueckner b, boy r g, siedlecki p, et al. epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human dna methyltransferases[j]. cancer research, 2005, 65(14): 6305-6311.

2'',3'',5''-Triacetyl -azacytidine Preparation Products And Raw materials

Raw materials

Preparation Products

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2'',3'',5''-Triacetyl -azacytidine Suppliers

China 91 India 4 United Kingdom 2 United States 11 USA 1 Global 109

SynZeal Research Pvt Ltd

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Email: standards@synzeal.com
Country: India
ProdList: 6514
Advantage: 58

Pharmaffiliates Analytics and Synthetics P. Ltd

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Email: mktg@pharmaffiliates.com
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A.J Chemicals

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View Lastest Price from 2'',3'',5''-Triacetyl -azacytidine manufacturers

Henan Fengda Chemical Co., Ltd

Product: 2'',3'',5''-Triacetyl -azacytidine 10302-78-0
Price: US $10.00-3.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-29

Henan Aochuang Chemical Co.,Ltd.

Product: 2'',3'',5''-Triacetyl -azacytidine 10302-78-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-26

10302-78-0, 2'',3'',5''-Triacetyl -azacytidineRelated Search:

Fazarabine Azacitidine Impurity 34 L-Cytidine 1-(diaminomethylidene)-3-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]urea 1,2,3,5-TETRA-O-ACETYL-BETA-L-XYLOFURANOSE Azacitidine Impurity 31 AMMELINE Azacitidine Impurity 33 5,6-dihydro-5-azacytidine Ammeline-13C3 5-Azacitidine 5'-Diphosphate (2-aminoethyl)carbamic acid Diazenecarboximidamide, N-(hydroxymethyl)-N-β-D-ribofuranosyl- 4-Amino-1-(2-O,3-O,5-O-tribenzoyl-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one β-D-Glucopyranose, 2-deoxy-2-[[[(1,2,3,4-tetrahydro-2,4-dioxo-5-pyrimidinyl)amino]thioxomethyl]amino]- Azacitidine Impurity 30 Azacitidine Impurity 41 5-Aza-2'-deoxycytidine

2'',3'',5''-Triacetyl -azacytidine

1,3,5-Triazin-2(1H)-one, 4-amino-1-(2,3,5-tri-o-acetyl-.beta.-D-ribofuranosyl)-

Nsc291930

S-Triazin-2(1H)-one, 4-amino-1-.beta.-D-ribofuranosyl-, triacetate (ester)

2',3',5'-triacetyl-5-Azacytidine

1,3,5-Triazin-2(1H)-one, 4-aMino-1-(2,3,5-tri-O-acetyl-b-D-ribofuranosyl)-

(2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(4-amino-2-oxo-1,3,5-triazin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate

Intermediate of Azacitidine

2'3'5'-triacetyl-5-Azacytosine

2',3',5'-Tri-O-Acetyl-Azacytidine

Azacitidine Triacetate

Triacetyl azacitidine

2,3,5-tri-O-acetyl-β-D-ribofuranose-4-amino-1,3,5-triazine

1,3,5-Triazin-2(1H)-one, 4-amino-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-

-O-triacetate

4-Amino-1-(2,3,5-tri-o-acetyl-beta-d-ribofuranosyl)-1,3,5-triazin-2(1h)-one

5-Azacytidine 2’,3’5’-O-triacetate

2,3,5-tri-O-acetyl-β-D-ribofuranose-4-amino-1,3,5-triazine

Azacitidine Impurity 48

2'',3'',5''-Triacetyl -azacytidine

2',3',5'-Tri-O-acetyl-5-azacytidine

2'3'5'-triacetyl-5-Azacytosine

2',3',5'-Triacetyl-5-azacytidine

triethylenetetramine-N,N,N',N'',N'''

10302-78-0