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3-(4-Pyridyl)indole

Product Name
3-(4-Pyridyl)indole
CAS No.
7272-84-6
Chemical Name
3-(4-Pyridyl)indole
Synonyms
3-(4-Pyridyl);3-(4-Pyridinyl)-;ROCK Inhibitor III;3-(4-Pyridyl)indole;Rho Kinase Inhibitor III;3-(4-Pyridinyl)-1H-indole;1H-Indole, 3-(4-pyridinyl)-;Rho Kinase Inhibitor III, Rockout;RHO KINASE INHIBITOR III; ROCK INHIBITOR III; ROCKOUT;Rho Kinase Inhibitor III, Rockout - CAS 7272-84-6 - Calbiochem
CBNumber
CB01564970
Molecular Formula
C13H10N2
Formula Weight
194.23
MOL File
7272-84-6.mol
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3-(4-Pyridyl)indole Property

storage temp. 
+2C to +8C
solubility 
DMSO, Methanol
form 
Yellow solid
color 
Yellow
Stability:
Light Sensitive
CAS DataBase Reference
7272-84-6
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
555553
Product name
Rho Kinase Inhibitor III, Rockout - CAS 7272-84-6 - Calbiochem
Packaging
10mg
Price
$159
Updated
2024/03/01
Cayman Chemical
Product number
17922
Product name
3-(4-Pyridyl)indole
Purity
≥98%
Packaging
5mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
17922
Product name
3-(4-Pyridyl)indole
Purity
≥98%
Packaging
10mg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
17922
Product name
3-(4-Pyridyl)indole
Purity
≥98%
Packaging
25mg
Price
$161
Updated
2024/03/01
Cayman Chemical
Product number
17922
Product name
3-(4-Pyridyl)indole
Purity
≥98%
Packaging
50mg
Price
$283
Updated
2024/03/01
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3-(4-Pyridyl)indole Chemical Properties,Usage,Production

Description

Two Rho-associated kinases (ROCK), ROCK1 and ROCK2, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. 3-(4-Pyridyl)indole is a ROCK1 inhibitor (IC50 = 25 μM) that promotes cell spreading, inhibits membrane blebbing, and induces dissolution of actin stress fibers in a wound healing assay. It also inhibits ROCK2 and PRK2, another Rho-dependent kinase, with similar potency, while inhibiting MSK-1 and PKA with relatively weaker potency.

Chemical Properties

Yellow Solid

Uses

Two Rho-associated kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. 3-(4-Pyridyl)indole is a ROCK-I inhibitor (IC50 = 25 μM) that promotes cell spreading, inhibits membrane blebbing, and induces dissolution of actin stress fibers in a wound healing assay. It also inhibits ROCK-II and PRK2, another Rho-dependent kinase, with similar potency, while inhibiting MSK-1 and PKA with relatively weaker potency.[Cayman Chemical]

Uses

A cell-permeable indolopyridine compound that acts as a selective, ATP-competitive inhibitor of Rho kinase (ROCK) activity.

Definition

ChEBI: 3-pyridin-4-yl-1H-indole is a member of indoles.

General Description

A cell-permeable indolopyridine compound that acts as a selective, reversible, and ATP-competitive inhibitor of Rho kinase activity with an IC50 of 25 μM. Does not inhibit the activation of Rho kinase nor does it affect the in vitro activities of MLCK, PKCα, and SAPK2a/p38α. Shown to be 5-fold less potent than Y-27632 (Cat. No. 688000; IC50 = ~5 μM), and display a similar specificity profile as H-89 (Cat. No. 371963). Affects cell migration, inhibits blebbing (IC50 = ~ 12 μM in M2 cells), and decreases stress fibers in Bulb 3T3 cells at 50 μM.

Biochem/physiol Actions

Cell permeable: yes

References

[1] yarrow j c, totsukawa g, charras g t, et al. screening for cell migration inhibitors via automated microscopy reveals a rho-kinase inhibitor[j]. chemistry & biology, 2005, 12(3): 385-395.
[2] amano m, fukata y, kaibuchi k. regulation and functions of rho-associated kinase[j]. experimental cell research, 2000, 261(1): 44-51.

3-(4-Pyridyl)indole Preparation Products And Raw materials

Raw materials

Preparation Products

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3-(4-Pyridyl)indole Suppliers

BOC Sciences
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16314854226
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info@bocsci.com
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United States
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9923
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Aladdin Scientific
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+1-+1(833)-552-7181
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sales@aladdinsci.com
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ApexBio Technology
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Cayman Chemical Company
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cayman@caymanchem.com
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Riedel-de Haen AG
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Medical Isotopes
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United States
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View Lastest Price from 3-(4-Pyridyl)indole manufacturers

Career Henan Chemica Co
Product
3-(4-Pyridyl)indole 7272-84-6
Price
US $0.37/g
Min. Order
1g
Purity
99%
Supply Ability
10kg,100kg Cherry 0956
Release date
2020-11-29

7272-84-6, 3-(4-Pyridyl)indoleRelated Search:


  • Rho Kinase Inhibitor III, Rockout - CAS 7272-84-6 - Calbiochem
  • Rho Kinase Inhibitor III
  • RHO KINASE INHIBITOR III; ROCK INHIBITOR III; ROCKOUT
  • ROCK Inhibitor III
  • 3-(4-Pyridyl)
  • 3-(4-Pyridinyl)-
  • Rho Kinase Inhibitor III, Rockout
  • 1H-Indole, 3-(4-pyridinyl)-
  • 3-(4-Pyridinyl)-1H-indole
  • 3-(4-Pyridyl)indole
  • 7272-84-6
  • Indole Derivatives
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Protein Kinase Inhibitors and Activators