ChemicalBook > CAS DataBase List > N-P-TOSYLGLYCINE

N-P-TOSYLGLYCINE

Product Name: N-P-TOSYLGLYCINE
CAS No.: 1080-44-0
Chemical Name: N-P-TOSYLGLYCINE
Synonyms: Tos-Gly;TOS-GLY-OH;AURORA 963;N-TOS-Gly-OH;N-TOSYLGLYCINE;N-4-tosylglycine;N-P-TOSYLGLYCINE;N-p-Tosylglycine 97%;Tosylaminoacetic acid;OTAVA-BB BB0123400526
CBNumber: CB0160643
Molecular Formula: C9H11NO4S
Formula Weight: 229.25
MOL File: 1080-44-0.mol

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N-P-TOSYLGLYCINE Property

Melting point:: 147-149 °C (lit.)
Boiling point:: 430.0±55.0 °C(Predicted)
Density: 1.369±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 3.41±0.10(Predicted)
color: White
CAS DataBase Reference: 1080-44-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3
HS Code: 2935.90.9500

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 403458
Product name: N-p-Tosylglycine
Purity: 97%
Packaging: 1g
Price: $31
Updated: 2023/06/20

TCI Chemical

Product number: T2803
Product name: N-(p-Toluenesulfonyl)glycine
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $31
Updated: 2025/07/31

TCI Chemical

Product number: T2803
Product name: N-(p-Toluenesulfonyl)glycine
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $88
Updated: 2025/07/31

TRC

Product number: T631720
Product name: N-Tosylglycine
Packaging: 5g
Price: $95
Updated: 2021/12/16

Chem-Impex

Product number: 16453
Product name: (4-Methylphenylsulfonylamino)aceticacid,≥98%(HPLC)
Purity: ≥98%(HPLC)
Packaging: 5G
Price: $23.3
Updated: 2021/12/16

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N-P-TOSYLGLYCINE Chemical Properties,Usage,Production

Uses

N-Tosylglycine is a sulfonamide derivative used to synthesize metal complexes which potentially displays antibacterial activity.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

98-59-9

56-40-6

1080-44-0

Sodium carbonate (Na2CO3, 1.590 g, 15 mmol) was added to a solution of glycine (12.5 mmol) in water (15 mL) under continuous stirring until completely dissolved. The solution was cooled to -5°C and p-toluenesulfonyl chloride (15 mmol) was added in four batches over 1 hour. The reaction mixture was continued to be stirred at room temperature for about 4 h. The progress of the reaction was monitored using thin layer chromatography (TLC, unfolding agent was MeOH/DCM, 1:9). Upon completion of the reaction, the mixture was acidified with 20% aqueous hydrochloric acid to pH 2. The crystals were collected by diafiltration and washed with pH 2.2 buffer. The pure product 2-(4-methylphenylsulfonamido)acetic acid was dried in a desiccator. The yield was 99.34% (2.8410 g) and the melting point was 88.4-88.6°C. FTIR (KBr, cm-1 ): 3448 (O-H, COOH), 3277 (N-H), 2957 (C-H, aliphatic), 1730 (C=O), 1598, 1440 (C=C), 1354, 1321 (2S=O). 1185 (SO2-NH), 1111, 1094 (C-N, C-O).1H NMR (DMSO-d6) δ: 7.90-7.88 (t, J=6.3 Hz, 1H, NH), 7.65-7.63 (d, J=8.6 Hz, 2H, ArH), 7.34-7.33 (d, J=8.05 Hz, 2H, ArH ), 3.52-3.51 (d, J=5.7 Hz, 2H, CH2), 2.34 (s, 3H, CH3).13C NMR (DMSO-d6) δ: 170.7 (C=O), 143.1, 138.4, 130.0, 127.1 (aryl carbons), 44.3 (CH2), 21.5 (CH3).HRMS-ESI (m/z): 228.0412 ([M-H]-, calculated value: 228.0408).

References

[1] European Journal of Medicinal Chemistry, 2017, vol. 135, p. 349 - 369
[2] PLoS ONE, 2018, vol. 13, # 1,
[3] Journal of the American Chemical Society, 2018, vol. 140, # 17, p. 5834 - 5841
[4] Journal of Molecular Catalysis A: Chemical, 2011, vol. 351, p. 41 - 45
[5] Organic and Biomolecular Chemistry, 2018, vol. 16, # 31, p. 5618 - 5625

N-P-TOSYLGLYCINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N-P-TOSYLGLYCINE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: N-P-TOSYLGLYCINE 1080-44-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: N-(p-Toluenesulfonyl)glycine 1080-44-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: N-P-TOSYLGLYCINE 1080-44-0
Price: US $100.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2018-07-26

1080-44-0, N-P-TOSYLGLYCINERelated Search:

TOS-PRO-OH N-(p-Tolylsulphonyl)-L-glutamic acid TOS-LYS(BOC)-OH N-(P-TOLUENESULFONYL)-L-PHENYLALANINE TOS-ARG-OH N-P-TOSYLGLYCINE TOS-ARG-OME HCL TOS-GLU-OH TOS-GLY-OSU Tosyl-S-Benzyl-L-cysteine TOS-MET-OH N-[P-TOLUENESULFONYL]-L-LYSINE METHYL ESTER HYDROCHLORIDE 2-([(4-METHYLPHENYL)SULFONYL]AMINO)-2-PHENYLACETIC ACID 4-METHYL-2-(TOLUENE-4-SULFONYLAMINO)-PENTANOIC ACID NEPSILON-CARBOBENZOXY-NALPHA-TOSYL-L-LYSINE 3-METHYL-2-(TOLUENE-4-SULFONYLAMINO)-BUTYRIC ACID 3-HYDROXY-2-(TOLUENE-4-SULFONYLAMINO)-PROPIONIC ACID 3-AMINO-2-(TOLUENE-4-SULFONYLAMINO)-PROPIONIC ACID

(4-METHYLPHENYLSULFONYLAMINO)ACETIC ACID

N-4-tosylglycine

N-TOS-Gly-OH

N-(4-Toluenesulfonyl)-glycine

N-(4-TOLUENESULFONYL)-GLYCINE N-P-TOSYLGLYCINE

(Toluene-4-sulfonylamino)-acetic acid

P-toluenesulfonate glycine

Tosylaminoacetic acid

2-[(4-methylphenyl)sulfonylamino]acetic acid

2-[(4-methylphenyl)sulfonylamino]ethanoic acid

2-[(4-Methylbenzene)sulfonaMido]acetic acid

N-Tosylglycine Tos-Gly-OH

2-(4-MethylphenylsulfonaMido)acetic acid

Tos-Gly

N-p-Tosylglycine 97%

(p-Toluenesulfonamido)acetic acid

Glycine, N-((4-methylphenyl)sulfonyl)-

Glycine, N-[(4-methylphenyl)sulfonyl]-

N-p-toluenesulfonyl-dl-glycine

N-TOSYLGLYCINE (GLYCINE-13C2

N-((4-METHYLPHENYL)SULFONYL)GLYCINE

P-TOLUENESULFONYLGLYCINE

OTAVA-BB BB0123400526

N-TOSYLGLYCINE

N-(P-TOLUENE SULFONYL) GLYCINE

N-P-TOSYLGLYCINE

TOS-GLY-OH

AURORA 963

N-(p-Toluenesulfonyl)glycine

N-P-TOSYLGLYCINE USP/EP/BP

N-p-Tosylglycine

1080-44-0

CH3C6H4SO2NHCH2CO2H

Amino Acid Derivatives

Peptide Synthesis

Specialty Synthesis

Glycine [Gly, G]