ChemicalBook > CAS DataBase List > 2-CHLORO-6-METHOXY-QUINOLINE

2-CHLORO-6-METHOXY-QUINOLINE

Product Name
2-CHLORO-6-METHOXY-QUINOLINE
CAS No.
13676-02-3
Chemical Name
2-CHLORO-6-METHOXY-QUINOLINE
Synonyms
Einecs 237-162-9;2-CHLORO-6-METHOXY-QUINOLINE;6-METHOXY-2-CHLORO-QUINOLINE;Quinoline, 2-chloro-6-methoxy-;2-Chloro-6-methoxy-1-azanaphthalene
CBNumber
CB0162238
Molecular Formula
C10H8ClNO
Formula Weight
193.63
MOL File
13676-02-3.mol
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2-CHLORO-6-METHOXY-QUINOLINE Property

Melting point:
106-107℃
Boiling point:
310.5±22.0 °C(Predicted)
Density 
1.267
storage temp. 
Inert atmosphere,Room Temperature
pka
0.37±0.43(Predicted)
form 
solid
Appearance
White to yellow Solid
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Safety

Hazard Codes 
Xn
Risk Statements 
22-41
Safety Statements 
26-39
WGK Germany 
3
HS Code 
2933499090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
BBO000233
Product name
2-Chloro-6-methoxyquinoline
Purity
Aldrich
Packaging
1g
Price
$286
Updated
2025/07/31
TRC
Product number
C368593
Product name
2-Chloro-6-methoxyquinoline
Packaging
100mg
Price
$60
Updated
2021/12/16
TRC
Product number
C368593
Product name
2-Chloro-6-methoxyquinoline
Packaging
500mg
Price
$110
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-5-5P
Product name
2-Chloro-6-methoxyquinoline
Packaging
1g
Price
$288
Updated
2021/12/16
Apolloscientific
Product number
OR307500
Product name
2-Chloro-6-methoxyquinoline
Packaging
1g
Price
$261
Updated
2021/12/16
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2-CHLORO-6-METHOXY-QUINOLINE Chemical Properties,Usage,Production

Synthesis

13676-00-1

13676-02-3

General procedure for the synthesis of 2-chloro-6-methoxyquinoline from 6-methoxyquinolin-2(1H)-one: 6-methoxyquinolin-2-ol (400 mg, 2.29 mmol) was dissolved in phosphorus trichloride (5.0 mL) and the reaction was carried out at reflux for 2 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in ethyl acetate (50 mL) and the organic layer was washed sequentially with saturated sodium bicarbonate solution (30 mL × 2). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated to give the crude product. The crude product was purified by silica gel column chromatography (petroleum ether/ethyl acetate = 10:1) to afford 2-chloro-6-methoxyquinoline (380 mg, 86% yield) as a white solid.1H NMR (CDCl3, 400 MHz): δ 7.92 (d, J = 8.4 Hz, 1H), 7.85 (d, J = 9.2 Hz, 1H), 7.32-7.25 ( m, 2H), 7.00 (d, J = 2.4 Hz, 1H), 3.86 (s, 3H).

References

[1] Patent: WO2012/48181, 2012, A1. Location in patent: Page/Page column 74
[2] Patent: WO2012/83165, 2012, A1. Location in patent: Page/Page column 91
[3] Ann. Inst. Pasteur, 1930, vol. 44, p. 719,736

2-CHLORO-6-METHOXY-QUINOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-6-METHOXY-QUINOLINE Suppliers

Canada 1 China 75 Germany 1 India 1 United Kingdom 2 United States 20 Global 100
Alchem Pharmtech,Inc.
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View Lastest Price from 2-CHLORO-6-METHOXY-QUINOLINE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
2-Chloro-6-methoxyquinoline 13676-02-3
Price
US $1.10-9.90/KG
Min. Order
1KG
Purity
99% min
Supply Ability
100kg
Release date
2025-08-18
R&D Scientific Inc.
Product
2-chloro-6-methoxyquinoline 13676-02-3
Price
US $2800.00/g
Min. Order
1g
Purity
99 %
Supply Ability
5000 Kg
Release date
2025-06-26
Career Henan Chemical Co
Product
2-CHLORO-6-METHOXY-QUINOLINE 13676-02-3
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
200KG
Release date
2018-12-23

13676-02-3, 2-CHLORO-6-METHOXY-QUINOLINERelated Search:

2-CHLORO-6-METHOXYQUINOLINE-3-CARBALDEHYDE 2-CHLORO-6-METHOXY-QUINOLINE 6-Methoxyquinoline 2-CHLORO-6-METHOXYQUINOLINE-3-CARBONITRILE 2-CHLORO-5,6,7-TRIMETHOXY-QUINOLINE-3-CARBALDEHYDE 2-CHLORO-6-METHOXY-3-METHYL-QUINOLINE 6-CHLORO-[1,3]DIOXOLO[4,5-G]QUINOLINE-7-CARBALDEHYDE 2-CHLORO-6-METHOXY-QUINOLINE-3-CARBOXYLIC ACID 2,6-DIMETHOXY-4-METHYLQUINOLINE 2-CHLORO-6-METHOXYQUINOLINE-3-METHANOL 2-CHLORO-6-(ETHYLOXY)QUINOLINE-3-CARBALDEHYDE 2-CHLORO-6-ETHOXYQUINOLINE-3-METHANOL 2-CHLORO-7-METHOXY-QUINOLINE-3-CARBOXYLIC ACID 2-CHLORO-7-METHOXY-QUINOLINE-3-CARBALDEHYDE 2-CHLORO-6-METHOXY-QUINOLINE-3-CARBALDEHYDE OXIME 2-CHLORO-6,7-DIMETHOXY-QUINOLINE-3-CARBALDEHYDE 7-CHLORO-4-METHOXY-QUINOLINE-3-CARBOXYLIC ACID 4-CHLORO-8-METHOXY-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER

  • Einecs 237-162-9
  • Quinoline, 2-chloro-6-methoxy-
  • 2-Chloro-6-methoxy-1-azanaphthalene
  • 6-METHOXY-2-CHLORO-QUINOLINE
  • 2-CHLORO-6-METHOXY-QUINOLINE
  • 13676-02-3