18-HYDROXY-11-DEOXYCORTICOSTERONE

Product Name
18-HYDROXY-11-DEOXYCORTICOSTERONE
CAS No.
379-68-0
Chemical Name
18-HYDROXY-11-DEOXYCORTICOSTERONE
Synonyms
18-HYDROXY DOC;18-HYDROXYDEOXYCORTICOSTERONE;4-PREGNEN-18,21-DIOL-3,20-DIONE;4-PREGNENE-18,21-DIOL-3,20-DIONE;18-HYDROXY-11-DEOXYCORTICOSTERONE;11-DEOXY-18-HYDROXYCORTICOSTERONE;18,21-dihydroxypregn-4-ene-3,20-dione;18,21-DIHYDROXY-4-PREGNENE-3,20-DIONE;Pregn-4-ene-3,20-dione, 18,21-dihydroxy-;18,20-EPOXY-20,21-DIHYDROXY-4-PREGNEN-3-ONE
CBNumber
CB0164085
Molecular Formula
C21H30O4
Formula Weight
346.46
MOL File
379-68-0.mol
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18-HYDROXY-11-DEOXYCORTICOSTERONE Property

Melting point:
171-173 °C
storage temp. 
2-8°C
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Safety

Safety Statements 
22-24/25
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10007851
Product name
18-hydroxy-11-deoxy Corticosterone
Packaging
500μg
Price
$75
Updated
2021/12/16
Cayman Chemical
Product number
10007851
Product name
18-hydroxy-11-deoxy Corticosterone
Packaging
1mg
Price
$143
Updated
2021/12/16
TRC
Product number
D239680
Product name
11-Deoxy-18-hydroxycorticosterone
Packaging
1mg
Price
$235
Updated
2021/12/16
AK Scientific
Product number
3712CA
Product name
18,21-Dihydroxypregn-4-ene-3,20-dione
Packaging
1mg
Price
$293
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0006430
Product name
18-HYDROXY-11-DEOXYCORTICOSTERONE
Purity
95.00%
Packaging
1MG
Price
$679.14
Updated
2021/12/16
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18-HYDROXY-11-DEOXYCORTICOSTERONE Chemical Properties,Usage,Production

Description

18-hydroxy-11-deoxy Corticosterone (18-OH-DOC) is a mineralocorticoid secreted by the zona fasciculata of the adrenal gland. Its biosynthesis is regulated by adrenocorticotropic hormone (ACTH; Item No. 24257) as well as angiotensin II (Item No. 17150), which increases 18-OH-DOC production in isolated human adrenal glomerulosa cells. 18-OH-DOC can be formed via conversion of 11-deoxy corticosterone (DOC; Item No. 22916) in human SK-MEL188 melanoma cells. 18-OH-DOC is an intermediate in the metabolism of progesterone (Item No. 15876) and can be converted to aldosterone (Item No. 15273) by the capsular portion of rat adrenal glands. Continuous infusion of 18-OH-DOC (200 μg/rat per day) increases systolic blood pressure in uninephrectomized saline-drinking rats. Plasma levels of 18-OH-DOC are elevated in a db/db mouse model of type 2 diabetes.

Uses

11-Deoxy-18-hydroxycorticosterone is an analog of Corticosterone (C695700); a glucocorticoid and intermediate in the biosynthesis of Aldosterone (A514700) which is an adrenocortical steroid isolated from the adrenal cortex.

Purification Methods

Recrystallise 18-hydroxy-11-deoxycorticosterone from Et2O/Me2CO to give crystals m 200-205o. When it is recrystallised from M2CO, it has m 191-195o. It has UV with max at 240nm. The 21-O-acetoxy-18-hydroxy derivative has m 158-159o (from Et2O/*C6H6), and the 21-O-acetoxy-18,20-epoxy derivative has m 149-154o (from Et2O). [Kahnt et al. Helv Chim Acta 38 1237 1955; Pappo J Am Chem Soc 81 1010 1959.]

18-HYDROXY-11-DEOXYCORTICOSTERONE Preparation Products And Raw materials

Raw materials

Preparation Products

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18-HYDROXY-11-DEOXYCORTICOSTERONE Suppliers

379-68-0, 18-HYDROXY-11-DEOXYCORTICOSTERONERelated Search:


  • 11-DEOXY-18-HYDROXYCORTICOSTERONE
  • 18-HYDROXY-11-DEOXYCORTICOSTERONE
  • 18-HYDROXYDEOXYCORTICOSTERONE
  • 18-HYDROXY DOC
  • 18,20-EPOXY-20,21-DIHYDROXY-4-PREGNEN-3-ONE
  • 18,21-DIHYDROXY-4-PREGNENE-3,20-DIONE
  • 4-PREGNENE-18,21-DIOL-3,20-DIONE
  • 4-PREGNEN-18,21-DIOL-3,20-DIONE
  • 18,21-dihydroxypregn-4-ene-3,20-dione
  • 11-Deoxy-18-hydroxycorticosterone, 18,20-Epoxy-20,21-dihydroxy-4-pregnen-3-one, 18,21-Dihydroxy-4-pregnene-3,20-dione
  • 18-Hydroxy-21-hydroxypregna-4-ene-3,20-dione
  • (8R,9S,10R,13R,14S,17S)-17-(2-hydroxyacetyl)-13-(hydroxymethyl)-10-methyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
  • (8R,9S,10R,13R,14S,17S)-17-(2-hydroxyethanoyl)-13-(hydroxymethyl)-10-methyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
  • (8R,9S,10R,13R,14S,17S)-17-glycoloyl-10-methyl-13-methylol-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
  • Pregn-4-ene-3,20-dione, 18,21-dihydroxy-
  • 379-68-0