18-HYDROXY-11-DEOXYCORTICOSTERONE
- Product Name
- 18-HYDROXY-11-DEOXYCORTICOSTERONE
- CAS No.
- 379-68-0
- Chemical Name
- 18-HYDROXY-11-DEOXYCORTICOSTERONE
- Synonyms
- 18-HYDROXY DOC;18-HYDROXYDEOXYCORTICOSTERONE;4-PREGNEN-18,21-DIOL-3,20-DIONE;4-PREGNENE-18,21-DIOL-3,20-DIONE;18-HYDROXY-11-DEOXYCORTICOSTERONE;11-DEOXY-18-HYDROXYCORTICOSTERONE;18,21-dihydroxypregn-4-ene-3,20-dione;18,21-DIHYDROXY-4-PREGNENE-3,20-DIONE;Pregn-4-ene-3,20-dione, 18,21-dihydroxy-;18,20-EPOXY-20,21-DIHYDROXY-4-PREGNEN-3-ONE
- CBNumber
- CB0164085
- Molecular Formula
- C21H30O4
- Formula Weight
- 346.46
- MOL File
- 379-68-0.mol
18-HYDROXY-11-DEOXYCORTICOSTERONE Property
- Melting point:
- 171-173 °C
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly, Sonicated), Methanol (Slightly, Heated)
- form
- Solid
- color
- White to Off-White
- LogP
- 1.571 (est)
Safety
- Safety Statements
- 22-24/25
N-Bromosuccinimide Price
- Product number
- R200077
- Product name
- 18,20-EPOXY-20,21-DIHYDROXYPREGN-4-EN-3-ONE
- Purity
- AldrichCPR
- Packaging
- 1MG
- Price
- $134
- Updated
- 2023/06/20
- Product number
- 10007851
- Product name
- 18-hydroxy-11-deoxy Corticosterone
- Packaging
- 1mg
- Price
- $176
- Updated
- 2024/03/01
- Product number
- 10007851
- Product name
- 18-hydroxy-11-deoxy Corticosterone
- Packaging
- 500μg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- D239680
- Product name
- 11-Deoxy-18-hydroxycorticosterone
- Packaging
- 1mg
- Price
- $235
- Updated
- 2021/12/16
- Product number
- 3712CA
- Product name
- 18,21-Dihydroxypregn-4-ene-3,20-dione
- Packaging
- 1mg
- Price
- $293
- Updated
- 2021/12/16
18-HYDROXY-11-DEOXYCORTICOSTERONE Chemical Properties,Usage,Production
Description
18-hydroxy-11-deoxy Corticosterone (18-OH-DOC) is a mineralocorticoid secreted by the zona fasciculata of the adrenal gland. Its biosynthesis is regulated by adrenocorticotropic hormone (ACTH; ) as well as angiotensin II , which increases 18-OH-DOC production in isolated human adrenal glomerulosa cells. 18-OH-DOC can be formed via conversion of 11-deoxy corticosterone (DOC; ) in human SK-MEL188 melanoma cells. 18-OH-DOC is an intermediate in the metabolism of progesterone and can be converted to aldosterone by the capsular portion of rat adrenal glands. Continuous infusion of 18-OH-DOC (200 μg/rat per day) increases systolic blood pressure in uninephrectomized saline-drinking rats. Plasma levels of 18-OH-DOC are elevated in a db/db mouse model of type 2 diabetes.
Uses
11-Deoxy-18-hydroxycorticosterone is an analog of Corticosterone (C695700); a glucocorticoid and intermediate in the biosynthesis of Aldosterone (A514700) which is an adrenocortical steroid isolated from the adrenal cortex.
Definition
ChEBI: 18-hydroxydeoxycorticosterone is a 21-hydroxy steroid, a 3-oxo-Delta(4) steroid, a 20-oxo steroid and a 18-hydroxy steroid.
Purification Methods
Recrystallise 18-hydroxy-11-deoxycorticosterone from Et2O/Me2CO to give crystals m 200-205o. When it is recrystallised from M2CO, it has m 191-195o. It has UV with max at 240nm. The 21-O-acetoxy-18-hydroxy derivative has m 158-159o (from Et2O/*C6H6), and the 21-O-acetoxy-18,20-epoxy derivative has m 149-154o (from Et2O). [Kahnt et al. Helv Chim Acta 38 1237 1955; Pappo J Am Chem Soc 81 1010 1959.]
18-HYDROXY-11-DEOXYCORTICOSTERONE Preparation Products And Raw materials
Raw materials
Preparation Products
18-HYDROXY-11-DEOXYCORTICOSTERONE Suppliers
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