2'-HYDROXY-2,4,4',5,6'-PENTAMETHOXYCHALCONE
- Product Name
- 2'-HYDROXY-2,4,4',5,6'-PENTAMETHOXYCHALCONE
- CAS No.
- 73694-15-2
- Chemical Name
- 2'-HYDROXY-2,4,4',5,6'-PENTAMETHOXYCHALCONE
- Synonyms
- RUBONE;Rubone >=98% (HPLC);2'-HYDROXY-2,4,5,4',6'-PENTAMETHOXYCHALCONE;2'-Hydroxy-2,4,4',5,6'-pentamethoxychalcone;2'-Hydroxy -2,4',4,5,6'- Penta methoxy Chalcone;2,4,5-Trimethoxybenzylidene(2-hydroxy-4,6-dimethoxyacetophenone);Rubone~2,4,5-Trimethoxybenzylidene(2-hydroxy-4,6-dimethoxyacetophenone);2-Propen-1-one, 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(2,4,5-trimethoxyphenyl)-, (2E)-
- CBNumber
- CB0164858
- Molecular Formula
- C20H22O7
- Formula Weight
- 374.38
- MOL File
- 73694-15-2.mol
2'-HYDROXY-2,4,4',5,6'-PENTAMETHOXYCHALCONE Property
- Boiling point:
- 586.1±50.0 °C(Predicted)
- Density
- 1.214±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: 2mg/mL, clear (warmed)
- pka
- 6.79±0.40(Predicted)
- form
- powder
- color
- yellow to orange
N-Bromosuccinimide Price
- Product number
- SML1311
- Product name
- Rubone
- Purity
- ≥98% (HPLC)
- Packaging
- 5 mg
- Price
- $64.8
- Updated
- 2025/07/31
- Product number
- CHM0008841
- Product name
- 2'-HYDROXY-2,4,4',5,6'-PENTAMETHOXYCHALCONE
- Purity
- 95.00%
- Packaging
- 50MG
- Price
- $600.32
- Updated
- 2021/12/16
2'-HYDROXY-2,4,4',5,6'-PENTAMETHOXYCHALCONE Chemical Properties,Usage,Production
Uses
Rubone, a chalcone analog, is a modulator of miR-34a. Rubone upregulates miR-34a expression in a p53 dependent manner, downregulates the downstream target Bcl-2 and Cyclin D1 expression, and suppresses hepatocellular carcinoma (HCC) growth in vivo. Rubone enhances the anticancer effect of Paclitaxel (PTX; HY-B0015) in PTX-resistant prostate cancer cell lines by reversing the expression of miR-34a downstream targets[1][2][3].
Definition
ChEBI: Rubone is a member of chalcones.
Biological Activity
Rubone has strong anticancer activity. Rubone and paclitaxel (PTX) combination therapy retarded cancer cell growth, migration and cancer stem-like cells (CSC) population growth.', 'Rubone is a miR34a modulator th at specifically restores miR34a in hepatocellular carcinoma cells with wild-type or mutated p53. Rubone potently inhibits growth of hepatocellular carcinoma in a mouse xenograft model. Rubone does not effect the growth of nontumorigenic human hepatocytes.', 'Rubone is a miR34a modulator th at specifically restores miR34a in hepatocellular carcinoma cells.
in vivo
Rubone monotherapy (20 mg/kg loaded PEG-PCD micelles; iv for five doses every other day) or combination therapy with PTX (10 mg/kg for each drug loaded PEG-PCD micelles) significantly upregulates miR-34a expression in tumor. The combination therapy inhibits tumor growth. Rubone monotherapy failed to suppress tumor cell proliferation[3].
| Animal Model: | 8 weeks old male nude mice transfected prostate cancer cells[3] |
| Dosage: | 20 mg/kg or 10 mg/kg for each drug (PTX and Rubone) loaded PEG-PCD micelles |
| Administration: | Intravenously for five doses every other day |
| Result: | Had little effect on body weight loss and inhibited tumor growth. Monotherapy or combination therapy with PTX significantly upregulated miR-34a expression in tumor. Alone or with PTX significantly reversed E-cadherin, Cyclin D1, and SIRT1 expression. |
References
[1] Zhangang Xiao, et al. Small molecule targeting miR-34a for cancer therapy. Mol Cell Oncol. 2015 Feb 24;2(1):e977160. DOI:10.4161/23723556.2014.977160
[2] Lu Zhang, et al. MicroRNA-34 family: a potential tumor suppressor and therapeutic candidate in cancer. J Exp Clin Cancer Res. 2019 Feb 4;38(1):53. DOI:10.1186/s13046-019-1059-5
[3] Di Wen, et al. Micellar Delivery of miR-34a Modulator Rubone and Paclitaxel in Resistant Prostate Cancer. Cancer Res. 2017 Jun 15;77(12):3244-3254. DOI:10.1158/0008-5472.CAN-16-2355
2'-HYDROXY-2,4,4',5,6'-PENTAMETHOXYCHALCONE Preparation Products And Raw materials
Raw materials
Preparation Products
2'-HYDROXY-2,4,4',5,6'-PENTAMETHOXYCHALCONE Suppliers
- Tel
- 4006356688 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- +49 5662 408730
- Fax
- +49 5662 4087320
- info@synchem.de
- Country
- Germany
- ProdList
- 4705
- Advantage
- 70
- Tel
- 021-QQ：65489617 15618227136
- Fax
- 21-5161 9052
- Sales@ATKchemical.com
- Country
- China
- ProdList
- 9125
- Advantage
- 58
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58
- Tel
- +8617013299288
- dj@sgtlifesciences.com
- Country
- China
- ProdList
- 12373
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing@energy-chemical.com
- Country
- China
- ProdList
- 44918
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24961
- Advantage
- 58
- Tel
- 13356901049
- mark@sklnchem.cn
- Country
- China
- ProdList
- 9995
- Advantage
- 58
- Tel
- 21-20338288
- ordercn@merckgroup.com
- Country
- China
- ProdList
- 6394
- Advantage
- 58
- Tel
- 51288865780
- sales@biosynth.com
- Country
- China
- ProdList
- 6051
- Advantage
- 58