4,4'-DIHYDROXY-2-METHOXYCHALCONE

Product Name: 4,4'-DIHYDROXY-2-METHOXYCHALCONE
CAS No.: 34221-41-5
Chemical Name: 4,4'-DIHYDROXY-2-METHOXYCHALCONE
Synonyms: ECHINATIN;Echinatin-RM;Retrochalcone;ECHINATIN(RG)(CALL);Echinatin, 10 mM in DMSO;4'-Dihydroxy-2-Methoxychalcone;4,4'-DIHYDROXY-2-METHOXYCHALCONE;4',4-DIHYDROXY-2-METHOXYCHALCONE;(E)-4,4'-Dihydroxy-2-methoxychalcone;4,4'-Dihydroxy-2-methoxy-trans-chalcone
CBNumber: CB1133864
Molecular Formula: C16H14O4
Formula Weight: 270.28
MOL File: 34221-41-5.mol

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4,4'-DIHYDROXY-2-METHOXYCHALCONE Property

Melting point:: 210°C (dec.)
Boiling point:: 509.8±50.0 °C(Predicted)
Density: 1.282±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.: 2-8°C
solubility: DMSO : 250 mg/mL (924.97 mM; Need ultrasonic)
form: powder
pka: 7.82±0.15(Predicted)
color: Orange
InChI: InChI=1S/C16H14O4/c1-20-16-10-14(18)8-4-12(16)5-9-15(19)11-2-6-13(17)7-3-11/h2-10,17-18H,1H3/b9-5+
InChIKey: QJKMIJNRNRLQSS-WEVVVXLNSA-N
SMILES: C(C1=CC=C(O)C=C1)(=O)/C=C/C1=CC=C(O)C=C1OC

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL83847
Product name: Echinatin
Purity: phyproof? Reference Substance
Packaging: 10mg
Price: $506
Updated: 2025/07/31

Usbiological

Product number: 361780
Product name: Echinatin
Packaging: 20mg
Price: $439
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FE73854
Product name: Echinatin
Packaging: 5mg
Price: $86
Updated: 2021/12/16

ChemScene

Product number: CS-0008288
Product name: Echinatin
Purity: 99.95%
Packaging: 5mg
Price: $119
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FE73854
Product name: Echinatin
Packaging: 10mg
Price: $150
Updated: 2021/12/16

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4,4'-DIHYDROXY-2-METHOXYCHALCONE Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from licorice root.

Uses

Echinatin is used as an anticancer agent inhibiting DNA topoisomerase IB and Tyrosyl-DNA phosphodiesterase 1 inhibitors.

in vivo

Echinatin (20 and 40 mg/kg, i.p.) inhibits LPS-induced septic shock in mice by inhibiting NLRP3 inflammasome activation^[2].
Echinatin (20-80 mg/kg, i.p.) shows cardioprotective effect, and relieves I/R-Induced Myocardial Injury in rats^[3].
Echinatin (20 and 50?mg/kg, p.o.) inhibits tumor growth and inhibits the AKT/mTOR pathway of KYSE270-derived tumor mice xenografts^[4].

Animal Model:	LPS-induced septic shock in mice^[1]
Dosage:	20 and 40 mg/kg
Administration:	i.p.
Result:	Inhibited LPS-induced IL-1β and TNF-α production. Reduced the proportion and the number of neutrophils in peritoneal lavage cells from mice.

4,4'-DIHYDROXY-2-METHOXYCHALCONE Preparation Products And Raw materials

Raw materials

Preparation Products

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4,4'-DIHYDROXY-2-METHOXYCHALCONE Suppliers

China 189 Germany 2 India 1 Japan 1 United Kingdom 5 United States 15 Global 213

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View Lastest Price from 4,4'-DIHYDROXY-2-METHOXYCHALCONE manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Echinatin 34221-41-5
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-02-26

Career Henan Chemical Co

Product: 4,4'-DIHYDROXY-2-METHOXYCHALCONE 34221-41-5
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg,5kg,50kg
Release date: 2020-01-18

34221-41-5, 4,4'-DIHYDROXY-2-METHOXYCHALCONERelated Search:

2'-HYDROXY-2,4,4',5,6'-PENTAMETHOXYCHALCONE 3-HYDROXY-7,2',4'-TRIMETHOXYFLAVONE LICOCHALCONE-A 2',4'-DIHYDROXY-2-METHOXYCHALCONE 2',6'-DIHYDROXY-4-METHOXYCHALCONE-4'-O-NEOHESPERIDOSIDE (E)-2',6'-Dihydroxy-4'-methoxychalcone,2',6'-DIHYDROXY-4'-METHOXYCHALCONE,DIHYDROXY-4'-METHOXYCHALCONE, 2',6'- 4,2'-DIHYDROXY-3-METHOXYCHALCONE,2',4-DIHYDROXY-3-METHOXYCHALCONE (E)-2',4'-Dihydroxy-6'-methoxychalcone trans-Chalcone 2,4,4'-TRIMETHOXYCHALCONE 2'-HYDROXY-2,4,4'-TRIMETHOXYCHALCONE 1-(4-HYDROXYPHENYL)-3-(2,3,4-TRIMETHOXYPHENYL)-2-PROPEN-1-ONE 4,4'-DIHYDROXY-2-METHOXYCHALCONE 2'-METHOXYTRICIN-4'-METHYL ETHER 5-HYDROXY-7,2',3',4',5'-PENTAMETHOXYFLAVONE 5'-BROMO-4,2'-DIHYDROXY-3-METHOXYCHALCONE 2',4-DIHYDROXY-4'-METHOXYCHALCONE 4',2-DIHYDROXY-3-METHOXYCHALCONE

(E)-3-(4-hydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one

ECHINATIN

(E)-3-(4-Hydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)-2-propen-1-one

(E)-4,4'-Dihydroxy-2-methoxychalcone

4,4'-Dihydroxy-2-methoxy-trans-chalcone

ECHINATIN(RG)(CALL)

4'-Dihydroxy-2-Methoxychalcone

Retrochalcone

4',4-DIHYDROXY-2-METHOXYCHALCONE

4,4'-DIHYDROXY-2-METHOXYCHALCONE

3-(4-Hydroxy-2-Methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one

2-Propen-1-one,3-(4-hydroxy-2-Methoxyphenyl)-1-(4-hydroxyphenyl)-, (2E)-

Retrochalcone, 98%, from Glycyrrhiza uralensis Fisch.

Echinatin-RM

Echinatin, 10 mM in DMSO

34221-41-5

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

sy

Chalcones