CARDAMONIN
- Product Name
- CARDAMONIN
- CAS No.
- 19309-14-9
- Chemical Name
- CARDAMONIN
- Synonyms
- (8CI);Cardamonin;CARDAMONIN(RG);(E)-Cardamonin;Cardamonin, >=98%;Alpinetin chalcone;6-Diaminocaproic acid;CAS19309-14-9 CARDAMONIN;(E)-Cardamonin ((E)-Cardamomin);Wnt/β-catenin Inhibitor, Cardamonin
- CBNumber
- CB31092214
- Molecular Formula
- C16H14O4
- Formula Weight
- 270.28
- MOL File
- 19309-14-9.mol
CARDAMONIN Property
- Melting point:
- 199～200℃
- Boiling point:
- 484.5±45.0 °C(Predicted)
- Density
- 1.282±0.06 g/cm3(Predicted)
- storage temp.
- room temp
- solubility
- DMSO: ≥20mg/mL
- form
- powder
- pka
- 7.00±0.40(Predicted)
- color
- yellow
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 weeks.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C8249
- Product name
- Cardamonin
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $168
- Updated
- 2024/03/01
- Product number
- 681672
- Product name
- Wnt/β-catenin Inhibitor, Cardamonin
- Packaging
- 2mg
- Price
- $172
- Updated
- 2024/03/01
- Product number
- 18310
- Product name
- Cardamonin
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $59
- Updated
- 2024/03/01
- Product number
- 18310
- Product name
- Cardamonin
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $112
- Updated
- 2024/03/01
- Product number
- PHL80379
- Product name
- Cardamomin
- Purity
- phyproof Reference Substance
- Packaging
- 10mg
- Price
- $400
- Updated
- 2024/03/01
CARDAMONIN Chemical Properties,Usage,Production
Description
Cardamonin (19309-14-9) inhibits NF-κB activation via inhibition of IκBα degradation and phosphorylation, IκB kinase activation and NF-κB nuclear translocation.1,2 Cardamonin displays anti-inflammatory activity in various models.3?Cell permeable.
Uses
Cardamonin has been used as a glycogen synthase kinase 3 (GSK3) inhibitor to study its effects on β-catenin loss and gain-of-function in human preimplantation embryos.
Definition
ChEBI: Cardamonin is a member of chalcones.
General Description
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Biological Activity
Chalone analog that display anti-inflammatory activity. Inhibits NO and PGE 2 production from LPS- and IFN- γ -induced RAW cells and inhibits TXB 2 production via the COX-1 and COX-2 pathways. Inhibits NF- κ B activation via inhibition of I κ B α degradation and phosphorylation, I κ B kinase activation and NF- κ B nuclear translocation.
Biochem/physiol Actions
Cardamonin is a calchone from Aplinia species (zingiberaceous plant species). Cardamonin inhibits pigmentation in melanocytes through suppression of Wnt/b-catenin signaling pathway. Cardamonin suppressed Wnt/b-catenin signaling by a mechanism involving proteasome-mediated degradation of b-catenin (GSK-3b-independent pathway). Research has shown that Cardamonin possesses anti-inflammatory activity via suppression of NF-kB nuclear translocation and Ik-Ba phosphorylation.
storage
Store at +4°C
References
1) Lee?et al. (2006),?Blockade of nuclear factor-kappaB signaling pathway and anti-inflammatory activity of cardamonin, a chalcone analog from Alpinia conchigera; J. Pharmacol. Exp. Ther.,?316?271 2) Israf?et al. (2007),?Cardamonin inhibits COX and iNOS expression via inhibition of p65NF-kappaB nuclear translocation and Ikappa-B phosphorylation in RAW 264.7 macrophage cells; Mol. Immunol.,?44?673 3) Ahmad?et al. (2006),?Cardamonin, inhibits pro-inflammatory mediators in activated RAW 264.7 cells and whole blood; Eur. Pharmacol. Exp. Ther., 538?188
CARDAMONIN Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from CARDAMONIN manufacturers
- Product
- Cardamonin 19309-14-9
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2019-10-23
- Product
- Cardamonin 19309-14-9
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- Analytical Standard
- Supply Ability
- 10 g
- Release date
- 2019-10-24
- Product
- CARDAMONIN 19309-14-9
- Price
- US $1.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2018-12-24